A review on traditional uses, phytochemistry, pharmacology, toxicology and the analytical methods of the genus Nardostachys

Miao, Wang; Yang, Tian-Tian; Rao, Yao; Wang, Zhimei; Dong, Xueqi; Zhang, Lihua; Han, Lifeng; Zhang, Yi; Wang, Tao; Zhu, Yan; Gao, Xiumei; Li, Tianxiang; Wang, Haiying; Xu, Yan‐Tong; Wu, Hong‐Hua

doi:10.1016/j.jep.2021.114446

Cited by 12 publications

(8 citation statements)

References 134 publications

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“…Then, the mixture was subjected to an ODS reversed-phase column eluted with gradient MeOH-H 2 O (30:70, 40:60, 50:50, 60:40, 70:30, 85:15, and 100:0 for 5, 5, 30, 13, 27, 4, and 10 column volumes, respectively, v/v) to obtain 9 fractions (Fr. [1][2][3][4][5][6][7][8][9]. Fraction 4 from the 50% MeOH elution, viz., 2-deoxokanshone M (1), was obtained (5.773 g) with a yield of 64.23%.…”

Section: Isolation and Identification Of The Main Degradation Product...mentioning

confidence: 99%

“…Nardostachys jatamansi DC., which has been extensively used for centuries in Himalayan countries to treat neurological and cardiovascular diseases [1,2], presents bioactive constituents such as nardosinone, nardosinonediol, isonardosinone, desoxo-narchinol A, and aristolone, which play crucial roles in the plant's therapeutic properties [2]. Among these constituents, nardosinone is integral for the authentication and quality evaluation of N. jatamansi [3][4][5], and it is stipulated to constitute at least 0.1% of the dried processed roots and rhizomes of the plant, according to the Chinese Pharmacopoeia [6].…”

Section: Introductionmentioning

confidence: 99%

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Degradation Profiling of Nardosinone at High Temperature and in Simulated Gastric and Intestinal Fluids

Xue

Yang

et al. 2023

Molecules

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Nardosinone, a predominant bioactive product from Nardostachys jatamansi DC, is well-known for its promising therapeutic applications, such as being used as a drug on anti-inflammatory, antidepressant, cardioprotective, anti-neuroinflammatory, anti-arrhythmic, anti-periodontitis, etc. However, its stability under varying environmental conditions and its degradation products remain unclear. In this study, four main degradation products, including two previously undescribed compounds [2–deoxokanshone M (64.23%) and 2–deoxokanshone L (1.10%)] and two known compounds [desoxo-narchinol A (2.17%) and isonardosinone (3.44%)], were firstly afforded from the refluxed products of nardosinone in boiling water; their structures were identified using an analysis of the extensive NMR and X–ray diffraction data and the simulation and comparison of electronic circular dichroism spectra. Compared with nardosinone, 2–deoxokanshone M exhibited potent vasodilatory activity without any of the significant anti-neuroinflammatory activity that nardosinone contains. Secondly, UPLC–PDA and UHPLC–DAD/Q–TOF MS analyses on the degradation patterns of nardosinone revealed that nardosinone degraded more easily under high temperatures and in simulated gastric fluid compared with the simulated intestinal fluid. A plausible degradation pathway of nardosinone was finally proposed using nardosinonediol as the initial intermediate and involved multiple chemical reactions, including peroxy ring-opening, keto–enol tautomerization, oxidation, isopropyl cleavage, and pinacol rearrangement. Our findings may supply certain guidance and scientific evidence for the quality control and reasonable application of nardosinone-related products.

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Section: Isolation and Identification Of The Main Degradation Product...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Degradation Profiling of Nardosinone at High Temperature and in Simulated Gastric and Intestinal Fluids

Xue

Yang

et al. 2023

Molecules

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“…pinnata seed oil and N . jatamansi root extract are used to cure various skin infections like eczema, vitiligo, and psoriasis, and are used in cosmetics, as well as can be applied to burns and skin inflammation ( Abbasi and Tahir, 2020 ; Singh, 2020 ; Mitra et al, 2021 ; Wang et al, 2021 ). The natural polymer pectin and guar gum are used as emulsifiers, binders, and stabilizers that provide the formulation with its gel-like appearance in the present study ( Kedir et al, 2022 ; Lopez-Martinez et al, 2022 ; Sayed et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel

Bhagyashree Devidas,

Patil,

Sharma

et al. 2023

Front. Chem.

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Milletia pinnata oil and Nardostachys jatamansi are rich sources of bioactive compounds and have been utilized to formulate various herbal formulations, however, due to certain environmental conditions, pure extract form is prone to degradation. Therefore, in this, study, a green hydrodistillation technology was used to extract M. pinnata oil and N. jatamansi root for the further application in development of pectin crosslinked carboxymethyl cellulose/guar-gum nano hydrogel. Both oil and extract revealed the presence of spirojatamol and hexadecanoic acid methyl ester. Varied concentrations (w/w) of cross-linker and gelling agent were used to formulate oil emulsion extract gel (OEEG1, OEG1, OEEG2, OEG2, OEEG3, OEG3, OEEG4, OEG4, OEEG5, OEG5), in which OEEG2 and OEG2 were found to be stable. The hydrogel displayed an average droplet size of 186.7 nm and a zeta potential of −20.5 mV. Endo and exothermic peaks and the key functional groups including hydroxyl, amide II, and amide III groups confirmed thermal stability and molecular structure. The smooth surface confirmed structural uniformity. Bactericidal activity against both Gram-positive (25.41 ± 0.09 mm) and Gram-negative (27.25 ± 0.01 mm) bacteria and anti-inflammatory activity (49.25%–83.47%) makes nanohydrogel a potential option for treating various infections caused by pathogenic microorganisms. In conclusion, the use of green hydrodistillation technology can be used to extract the bioactive compounds that can be used in formulation of biocompatible and hydrophobic nanohydrogels. Their ability to absorb target-specific drugs makes them a potential option for treating various infections caused by pathogenic microorganisms.

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“…The analytical methods traditionally used to quantify these metals are atomic absorption spectrometry 2 , molecular absorption spectrophotometry 3 , among others 4 . Despite the versatility, sensitivity and efficiency of these methodologies, they have the disadvantage of sophisticated and expensive instrumentation.…”

Section: Introductionmentioning

confidence: 99%

Determination of Copper and Iron in Real Sample of Water and Ethanol Using Square Wave Voltammetry with a Micro/Nano Boron-Doped Diamond Electrode

2022

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Currently, the search for a more economical alternative with adequate selectivity, sensitivity and reproducibility in the determination of metallic ions is important for the development of reliable methodologies for the determination of these contaminants. This work investigates a boron-doped micro/nano diamond electrode, with different morphology and structure compared to those discussed in the literature, for the detection of copper and iron in aqueous and ethanolic environments. Internal validation of the Square Wave Voltammetry was applied. The methodology was submitted to validation by: selectivity, linearity, precision (interday test), accuracy (percentage of recovery) and detection and quantification limits. The results indicated that this type of electrode showed good response to determinations in aqueous and ethanolic environments, with good selectivity, linearity, accuracy (recovery between 70% and 110%) and precision, presenting the best detection and quantification limits for the aqueous. The methodology using a boron-doped diamond micro/nano electrode was suitable for the determination of copper and iron metals in both matrices.

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A review on traditional uses, phytochemistry, pharmacology, toxicology and the analytical methods of the genus Nardostachys

Cited by 12 publications

References 134 publications

Degradation Profiling of Nardosinone at High Temperature and in Simulated Gastric and Intestinal Fluids

Degradation Profiling of Nardosinone at High Temperature and in Simulated Gastric and Intestinal Fluids

Green extraction of Milletia pinnata oil for the development, and characterization of pectin crosslinked carboxymethyl cellulose/guar gum herbal nano hydrogel

Determination of Copper and Iron in Real Sample of Water and Ethanol Using Square Wave Voltammetry with a Micro/Nano Boron-Doped Diamond Electrode

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