Liquid chromatographic analysis of certain commercial formulations for non‐opioid analgesics

Abstract

A simple and sensitive method for separation and quantitative determination of non-opioid analgesics from pharmaceutical preparations has been developed and validated. Commercial formulations of three non-opioid analgesics, viz. paracetamol, ibuprofen and diclofenac, were chosen for present studies. These were extracted, isolated, purified and recrystallized and were characterized by melting point, lambda(max) and IR. Quantitative determination was carried out using HPLC and TLC supplemented with UV spectrophotometry.

Electrochemical investigations of diclofenac at edge plane pyrolytic graphite electrode and its determination in human urine

“…The analytical methods are based on gas chromatography [12], gas chromatography-mass spectrometry [13], HPLC [14][15][16][17], spectrophotometry [18,19], thin layer chromatography [20], liquid chromatography [21], adsorptive differential pulse voltammetry [22], flow-injection spectrophotometry [23] and capillary zone electrophoresis [3]. Most of the methods reported suffer from disadvantages such as laborious, time-consuming and tedious liquid-liquid extraction or solid-phase extraction as sample preparation procedures, long response time, requirement of expensive instruments and low detection capability.…”

UV Spectrophotometric Simultaneous Determination of Paracetamol and Ibuprofen in Combined Tablets by Derivative and Wavelet Transforms

“…In the literature, the determination of paracetamol and ibuprofen could be simultaneously performed by HPLC, CE, and HPTLC [29–32]. Their spectrophotometric determination was also studied by applying chemometrics and derivative approach [33–35].…”

Inexpensive Green Method for Diclofenac Assay Utilizing Sequential Injection Chromatography

“…Using Scopus Ò database, more than 15 methods were retrieved within the recent 5 years. Gravimetry [13], spectrophotometry [14][15][16], fluorometry [17], Raman spectroscopy [18,19], diffuse reflectance photometry [20], potentiometry [21], multisyringe flow injection analysis with amperometry [22], liquid chromatography [23,24], HPLC [25][26][27][28], high performance thin layer chromatography [29,30], and gas chromatography-mass spectrometry [31] were utilized.…”