Electrochemical investigations of diclofenac at edge plane pyrolytic graphite electrode and its determination in human urine

“…Several methods for the determination of DCF have been reported in the literature, such as high performance liquid chromatography (HPLC) with electrochemical or UV detection [5][6][7], spectrophotometry [8,9], spectrofluorometry [10,11], gas chromatography [12], capillary zone electrophoresis [13,14], and electrochemistry [15,3,[16][17][18][19][20][21]. In all electrochemical methods, modified electrodes were used due to the gradual passivation or contamination of unmodified solid working electrodes occurred during the DCF oxidation (adsorption of the electrochemically generated product).…”

Section: Introductionmentioning

confidence: 99%

Flow‐Injection Amperometric Method for Determination of Diclofenac in Pharmaceutical Formulations Using a Boron‐Doped Diamond Electrode

et al. 2011

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This paper describes the determination of diclofenac (DCF) in pharmaceutical formulations using flow injection method with multiple pulse amperometric detection. Unmodified boron-doped diamond (BDD) is used as working electrode and 0.10 mol L À1 sulfuric acid as supporting electrolyte. The system exhibited sharp current response peaks and excellent stability of the analytical signal (RSD = 1.0 %, n = 10). The linear response range from 5 to 50 mmol L À1 was obtained by using an injected volume of 50 mL, with good correlation coefficient (R = 0.998). The limits of detection (LOD) and quantification (LOQ) were found to be 0.14 and 0.46 mmol L À1 , respectively. The sampling frequency was calculated about 135 injections h À1.

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“…EPPGE/ BPPGE was prepared as reported in literature [17]. The SWNT modified glassy carbon electrode was prepared by reported method [13].…”

Section: Instrumentationmentioning

confidence: 99%

The Electrocatalytic Activity of Bare Pyrolytic Graphite and Single Wall Carbon Nanotube Modified Glassy Carbon Sensors Is Same for the Quantification of Bisoprolol Fumarate

Goyal¹,

Chatterjee²,

Singh³

et al. 2012

AJAC

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A comparison of voltammetric behavior of bisoprolol fumarate (BF) at edge and basal plane pyrolytic graphite electrodes (EPPGE/BPPGE) has been made with single wall carbon nanotube modified glassy carbon. The electrochemical properties are investigated exercising the cyclic voltammetry and square wave voltammetry (SWV). Enhanced peak current associated with bisoprolol fumarate oxidation at EPPGE is due to its better electron transfer property. Quantification of bisoprolol fumarate was carried out at pH 7.2 at both the pyrolytic graphite electrodes. Well-defined peak has been observed at ~792 and 954 mV at EPPGE and BPPGE respectively for bisoprolol fumarate oxidation. The detection limit is found to be 2.8 × 10 -7 M and 7.3 × 10 -7 M for EPPGE and BPPGE respectively. A comparison of common quantification parameters for bisoprolol at carbon nanotube modified glassy carbon electrode and bare BPPGE and EPPGE has been made and it is observed that carbon naotube modified glassy carbon exhibits sensitivity and detection limit close to that observed at bare basal plane pyrolytic graphite electrode. The method developed is applicable for determination of bisoprolol fumarate in pharmaceutical preparations and real samples.

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Electrochemical investigations of diclofenac at edge plane pyrolytic graphite electrode and its determination in human urine

Cited by 86 publications

References 29 publications

Gold nanoparticle/multi-walled carbon nanotube modified glassy carbon electrode as a sensitive voltammetric sensor for the determination of diclofenac sodium

Gold nanoparticle/multi-walled carbon nanotube modified glassy carbon electrode as a sensitive voltammetric sensor for the determination of diclofenac sodium

Flow‐Injection Amperometric Method for Determination of Diclofenac in Pharmaceutical Formulations Using a Boron‐Doped Diamond Electrode

The Electrocatalytic Activity of Bare Pyrolytic Graphite and Single Wall Carbon Nanotube Modified Glassy Carbon Sensors Is Same for the Quantification of Bisoprolol Fumarate

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