LIPUS Enhance Elongation of Neurites in Rat Cortical Neurons through Inhibition of GSK-3β

Low‐intensity pulsed ultrasound accelerates nerve regeneration following inferior alveolar nerve transection in rats

“…As an effect of LIPUS exposure on cultured cortical neurons, it was reported that neurite extension was enhanced by LIPUS exposure, accompanied by marked deactivation of glycogen synthase kinase-3 beta (GSK-3b) (21,22). Exposure of cultured rat primary somatosensory cortical neurons to LIPUS (10 mW cm À2 ), daily for 5 min, decreased their intracellular expression of GSK-3b, which resulted in enhanced neurite elongation (21). These findings indicate that deactivation of GSK-3b by LIPUS enhances the elongation of neurites in unmyelinated neurons.…”

Effect of Low-Intensity Pulsed Ultrasound on Nerve Repair

“…Then we examined the change in the activity and the www.intechopen.com mRNA expression of GSK-3 to determine the intracellular mechanism of neurite outgrowth following irradiation by LIPUS. It is concluded that LIPUS can enhance elongation of neurites and it is possible through the decreased expression of GSK-3 (Ren, Li et al 2010). A LIPUS-therapeutic apparatus, Nexson-The-P41 was constructed according to instructions from Nexus Biomedical Devices (Hangzhou, China).…”

“…To measure the length of neurites to examine whether LIPUS is effective for the elongation of the neuronal processes, we examined the change in the activity and the mRNA expression www.intechopen.com of GSK-3beta to determine the intracellular mechanism of neurite outgrowth following irradiation by LIPUS (Ren, Li et al 2010). Fig.…”

“…From these findings, we postulate that when neurons are irradiated by LIPUS, an unknown intracellular mechanism may be activated as a response to this "injury" and, consequently, neurons reduce the mRNA expression of GSK-3. The decrease of GSK-3beta activity comes from reduced expression, but not through the PI3-kinase/Akt/GSK-3 signaling pathway (Ren, Li et al 2010). …”

Estimulação Óssea Através De Ultrasson

“…Alguns trabalhos mostram o potencial da força vibratórias em modular a síntese de mediadores pró-inflamatórios (CHERIAN et al, 2005;GENETOS et al, 2005;LI et al, 2005;MUKAI, et al, 2005;IKEDA et al, 2006;MADDI et al, 2006;TAKAYAMA et al, 2007;XU et al, 2007;REN;LI;LIN, 2010;ANGLE et al, 2011;AL-DAGHREER et al, 2012;GUSMÃO;MARIOLANI;BELANGERO, 2012;XUE et al, 2013). Durante a remodelação óssea, IL-1 e IL-17 têm sido relacionadas com ativação osteoclástica, modulando a via de RANK-RANKL-OPG mediado pela ativação de M-CSF (TANABE et al, 2005;LEE, 2013).…”