Liposomes as Vehicles for Lutein: Preparation, Stability, Liposomal Membrane Dynamics, and Structure

Tan, Chen; Xia, Shuqin; Xue, Jingyi; Xie, Jiehong; Feng, Bo; Zhang, Xiaoming

doi:10.1021/jf402085f

Cited by 135 publications

(78 citation statements)

References 48 publications

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“…G is an instrumental correction factor grating correction coefficient. 23,24) In addition, the increase in SCLL membrane fluidity was calculated as follows:…”

mentioning

confidence: 99%

Potential of Stratum Corneum Lipid Liposomes for Screening of Chemical Skin Penetration Enhancers

Sakdiset

Todo

Sugibayashi

2017

CHEMICAL & PHARMACEUTICAL BULLETIN

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The evaluation of effective skin chemical penetration enhancers (CPEs) is a crucial process in the development of transdermal and dermal formulations with the capacity to overcome the stratum corneum barrier. In the present study, we aimed to investigate the potential of stratum corneum lipid liposomes (SCLLs) as an alternative tool for the screening of various types and concentrations of CPEs. SCLLs were prepared using a thin-film hydration technique, and two types of fluorescent probes ( Key words stratum corneum lipid liposome; chemical skin penetration enhancer; liposome; high-throughput screening Skin has been recognized as an application site of therapeutic drugs for several decades. However, only small numbers of drugs are available nowadays intended for systemic absorption through the skin. The stratum corneum (SC), the outermost layer of the skin, provides a strong barrier to protect against extraneous molecules from entering the body, and thus limits the skin penetration of drugs. The structure of the SC consists of keratin-rich corneocytes embedded in an intercellular lipid matrix.

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“…G is an instrumental correction factor grating correction coefficient. 23,24) In addition, the increase in SCLL membrane fluidity was calculated as follows:…”

mentioning

confidence: 99%

Potential of Stratum Corneum Lipid Liposomes for Screening of Chemical Skin Penetration Enhancers

Sakdiset

Todo

Sugibayashi

2017

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…25 A series concentration (0.5%, 1%, 2%, 5%, 10%, 20%, 50%, 100%) of Triton X-100 solutions was prepared. The Triton X-100 solutions (10 μL) were added to the GA derivative-mediated liposomes (190 μL) in the 96-well plates in triplicate.…”

Section: Analysis Of Liposomal Membrane Stabilitymentioning

confidence: 99%

Hepatocellular carcinoma-targeted effect of configurations and groups of glycyrrhetinic acid by evaluation of its derivative-modified liposomes

Sun

Dai

Yin

et al. 2018

IJN

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Background There are abundant glycyrrhetinic acid (GA) receptors on the cellular membrane of hepatocytes and hepatocellular carcinoma (HCC) cells. The receptor binding effect might be related to the structure of the guiding molecule. GA exists in two stereoisomers with C3-hydroxyl and C11-carbonyl active groups. Purpose The objective of this study was to investigate the relationship between the HCC-targeted effect and the configurations and groups of GA. Methods and results Different GA derivatives (18β-GA, 18α-GA, 3-acetyl-18β-GA [3-Ace-GA] and 11-deoxy-18β-GA [11-Deo-GA]) were used to investigate the targeting effect of GA’s configurations and groups on HCC cells. The EC 50 values of competition to binding sites and the ratio of specific binding in HepG2 cells showed that 18β-GA and 3-Ace-GA demonstrated significant competitive effect with fluorescein isothiocyanate (FITC)-labeled GA. Then, the GA derivatives were distearoyl-phosphatidylethanolamine (DSPE)-PEGylated. 18β-GA-, 18α-GA-, 3-Ace-GA-and 11-Deo-GA-modified liposomes were prepared and characterized by size, zeta potential, encapsulation efficiency, loading capacity, leakage and membrane stability. Evaluation on the cellular location in vitro and tumor targeting in vivo was carried out. Compared to common long-circulation liposome (PEG-Lip), more 18β-GA- and 3-Ace-GA-modified liposomes aggregated around HepG2 cells in vitro in short time and transferred into HCC tumors in vivo for a longer time. Conclusion The β-configuration hydrogen atom on C18 position of GA played the most important role on the targeting effect. C11-carbonyl and C3-hydroxy groups of GA have certain and little influence on targeting action to HCC, respectively. In general, GA might be a promising targeting molecule for the research on liver diseases and hepatoma therapy.

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“…[22] Lutein was incorporated into liposomes and it was demonstrated that a liposomal membrane can strongly retain lutein, thereby improving the storage stability. [23] Lutein and zeaxanthin enriched health food (ready mix) was developed and studied at different temperature and wavelengths. [24] Similar study was conducted on the thermal treatment and light exposure on degradation and isomerization of lutein.…”

Section: Storage and Stability Of Luteinmentioning

confidence: 99%

Lutein – The Less Explored Carotenoid

Hirdyani¹

2017

WJPR

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Lutein and zeaxanthin are xanthophyll carotenoids found particularly in dark-green leafy vegetables and in egg yolks. They are widely distributed in tissues and are the principal carotenoids in the eye lens and macular region of the retina. Epidemiologic studies depicts an inverse relationship between xanthophyll intake and Retinitis Pigmentosa (RP), cataract and Age-Related Macular Degeneration (ARMD) thus suggesting a protective role of these compounds in the eye. Some observational studies have also shown these xanthophylls may help reduce the risk of certain types of cancer and diabetes. It is also known to have beneficial effects on skin health. Emerging studies suggest as well a potential contribution of lutein and zeaxanthin to the prevention of various cardiovascular diseases too. The use of lutein as a nutritional supplement has been explored in recent years. It is used as a major pharmaceutical but its application as a nutraceutical still needs to be emphasised upon as its industrial application will be very promising in near future. Lutein is a promising biologically active component in the food industry.

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Liposomes as Vehicles for Lutein: Preparation, Stability, Liposomal Membrane Dynamics, and Structure

Cited by 135 publications

References 48 publications

Potential of Stratum Corneum Lipid Liposomes for Screening of Chemical Skin Penetration Enhancers

Potential of Stratum Corneum Lipid Liposomes for Screening of Chemical Skin Penetration Enhancers

Hepatocellular carcinoma-targeted effect of configurations and groups of glycyrrhetinic acid by evaluation of its derivative-modified liposomes

Lutein – The Less Explored Carotenoid

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