2018
DOI: 10.2147/ijn.s153944
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Abstract: Background There are abundant glycyrrhetinic acid (GA) receptors on the cellular membrane of hepatocytes and hepatocellular carcinoma (HCC) cells. The receptor binding effect might be related to the structure of the guiding molecule. GA exists in two stereoisomers with C3-hydroxyl and C11-carbonyl active groups. Purpose The objective of this study was to investigate the relationship between the HCC-targeted effect and the configurations and groups of GA. … Show more

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Cited by 28 publications
(24 citation statements)
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“…Glycyrrhetinic acid (GA), a pentacyclic triterpenoid, is one of the main bioactive components of licorice. It has been shown that GA receptors (GA-R) are highly expressed in liver cancer cells 24. Therefore, GA-modified micelles could selectively target liver cancer cells and remarkably improve the accumulation of drugs in tumors 25…”
Section: Introductionmentioning
confidence: 99%
“…Glycyrrhetinic acid (GA), a pentacyclic triterpenoid, is one of the main bioactive components of licorice. It has been shown that GA receptors (GA-R) are highly expressed in liver cancer cells 24. Therefore, GA-modified micelles could selectively target liver cancer cells and remarkably improve the accumulation of drugs in tumors 25…”
Section: Introductionmentioning
confidence: 99%
“…Ligand-modified vectors can directly cross tumor cellular membranes through the specific binding of the ligand to receptor and endocytosis and deliver active substances (e.g., small molecule drugs, polypeptides, nucleic acid, and so on) into the cytoplasm or nucleus with minimal cytotoxicity to normal cells. For liver cancer, the commonly studied ligands include hyaluronic acid, 17,18 folic acid, 19,20 galactose, 21 glycyrrhetinic acid, 22 and so on. Among these, folic acid has been widely studied and achieved good results.…”
Section: Introductionmentioning
confidence: 99%
“…They also mitigate side effects by reducing dosages of chemotherapy drugs to achieve the same therapeutic goals. Numerous receptors mediate active liver-targeted drug delivery for the treatment of liver cancer, including the asialoglycoprotein receptor (7), glycyrrhetinic acid (GA) receptor (GA-R) (8)(9)(10), hyaluronan (HA) receptor (11)(12)(13) and folate receptor (14,15).…”
Section: Introductionmentioning
confidence: 99%