2010
DOI: 10.1111/j.1755-3768.2009.01584.x
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Liposomes as an ocular delivery system of fluconazole: in‐vitro studies

Abstract: Acta Ophthalmol. 2010: 88: 901–904 Abstract. Purpose:  To study the clinical effect of topical controlled‐release ophthalmic fluconazole liposomal formulation and to compare its effect with fluconazole solution in a reproducible model of Candida keratitis in rabbits. Methods:  Forty adult rabbits were included in this study. Right eyes were inoculated with freshly prepared Caindida albicans strain no. 4925 and showed signs of infected keratitis. The rabbits were divided randomly into two groups: in the first g… Show more

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Cited by 75 publications
(33 citation statements)
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“…Regardless of the drug choice, successful therapy requires prolonged frequent drug administration and therefore adherence of patients to treatment is also an important factor affecting the outcome of treatment. In addition, liposomal preparation of anti-fungal drugs are also under trail and has demonstrated some efficacy in rabbit models [1,57]. Furthermore [156] compared the efficacy of topical clotrimazole-β-cyclodextrin (CBC), a comparatively new anti-fungal compared to amphotericin B and concluded that CBC reduces the period of treatment on average by a duration of 1 week.…”
Section: Treatmentmentioning
confidence: 99%
“…Regardless of the drug choice, successful therapy requires prolonged frequent drug administration and therefore adherence of patients to treatment is also an important factor affecting the outcome of treatment. In addition, liposomal preparation of anti-fungal drugs are also under trail and has demonstrated some efficacy in rabbit models [1,57]. Furthermore [156] compared the efficacy of topical clotrimazole-β-cyclodextrin (CBC), a comparatively new anti-fungal compared to amphotericin B and concluded that CBC reduces the period of treatment on average by a duration of 1 week.…”
Section: Treatmentmentioning
confidence: 99%
“…The changes in the percentage of BD content during the six months were statistically insignificant (p>0.05) indicating good chemical stability. Many studies reported good chemical stability at refrigerated condition (4 °C) and at room temperature (25 °C) [19,25,26,29,51,52].…”
Section: Discussionmentioning
confidence: 99%
“…A novel liposomal preparation of fluconazole for topical application demonstrated efficacy in rabbit models [47] and a recent study of 11 patients with proven Candida keratitis [48]. Some level of improvement was noted, but with the small study size and lack of control or comparison arms it is difficult to gauge its place in the therapeutic armamentarium.…”
Section: New Topical Anti-fungal Preparationsmentioning
confidence: 99%