Betamethasone Dipropionate Gel for Treatment of Localized Plaque Psoriasis

Gizaway, Sanaa El; Fadel, Maha; Mourad, Basma; Elnaby, Fatma El-zahraa Abd

doi:10.22159/ijpps.2017v9i8.18571

Cited by 18 publications

(7 citation statements)

References 28 publications

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“…A constellation of therapy is available which can control the disease of psoriasis among people. Along with existing therapies, the novel therapies such as anticytokines, small molecule inhibitor, NGF inhibitor, and corticosteroids [81] and other therapies became more prevalent in recent years for the treatment of psoriasis. Although various therapies and drugs are present in the market, still no drugs can permanently cure psoriasis and few of them elicit severe adverse effects.…”

Section: Resultsmentioning

confidence: 99%

Existing and Novel Therapies for Psoriasis

Navya

Jain

2018

Asian J Pharm Clin Res

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Psoriasis is adjudged as prototypic papulosquamous skin condition attributed by the erythematous papules (or) plaques. It occurs at any age but commonly seen in age groups of 20-30 and 50-60 years. Psoriasis affects around 2% of the world population. Psoriasis has a broad spectrum of skin indications occurring in different forms with common characteristics. It is clinically classified as non-pustular and pustular psoriasis. Existing therapies include topical therapy, systematic therapy, and phototherapy. Biological drugs and novel immunological factors have been identified as alternative therapy to conventional therapies. These biological drugs show more efficacies with fewer side effects in long-term application.

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Section: Resultsmentioning

confidence: 99%

Existing and Novel Therapies for Psoriasis

Navya

Jain

2018

Asian J Pharm Clin Res

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“…Lei et al prepared a tacrolimus-loaded transferosome, which showed increased anti-atopic dermatitis activity compared to commercial tacrolimus ointment (Protopic ® ) liposomes-gel [75]. Gizaway et al fabricated betamethasone di-propionate-loaded transferosomes that showed antipsoriatic activity, along with greater tolerability and better safety than the available tacrolimus formulation [76].…”

Section: Applications Of Particulate Drug Delivery Systems In Psoriasismentioning

confidence: 99%

Promising Strategies of Colloidal Drug Delivery-Based Approaches in Psoriasis Management

et al. 2021

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Psoriasis is a chronic inflammatory autoimmune disorder that moderately affects social and interpersonal relationships. Conventional treatments for psoriasis have certain problems, such as poor drug penetration through the skin, hyper-pigmentation, and a burning sensation on normal and diseased skin. Colloidal drug delivery systems overcome the pitfalls of conventional approaches for psoriasis therapeutics and have improved patient safety parameters, compliance, and superior effectiveness. They also entail reduced toxicity. This comprehensive review’s topics include the pathogenesis of psoriasis, causes and types of psoriasis, conventional treatment alternatives for psoriasis, the need for colloidal drug delivery systems, and recent studies in colloidal drug delivery systems for the treatment of psoriasis. This review briefly describes colloidal drug delivery approaches, such as emulsion systems—i.e., multiple emulsion, microemulsion, and nano-emulsion; vesicular systems—i.e., liposomes, ethosomes, noisomes, and transferosomes; and particulate systems—i.e., solid lipid nanoparticles, solid lipid microparticles, nano-structured lipid carriers, dendrimers, nanocrystals, polymeric nanoparticles, and gold nanoparticles. The review was compiled through an extensive search of the literature through the PubMed, Google Scholar, and ScienceDirect databases. A survey of literature revealed seven formulations based upon emulsion systems, six vesicular drug delivery systems, and fourteen particulate systems reported for antipsoriatic drugs. Based on the literature studies of colloidal approaches for psoriasis management carried out in recent years, it has been concluded that colloidal pharmaceutical formulations could be investigated broadly and have a broad scope for effective management of many skin disorders in the coming decades.

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“…Hence, drug action increases and side effects decrease [13]. Topical dosage forms are superior drug delivery systems because they avoid firstpass hepatic metabolism, gastric degradation and improve penetration of the drug into skin layers [14,15]. Surface-active agent vesicles are an alternative drug delivery system to conventional liposomes.…”

Section: Introductionmentioning

confidence: 99%

Topical Delivery of Quercetin Loaded Transfersomes for Wound Treatment: In Vitro and in Vivo Evaluation

et al. 2021

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Objective: To design topical Quercetin (Qc)-loaded transfersomes (TFs) for wound treatment. Methods: Qc-loaded TFs were prepared by thin-film hydration technique using 2241full factorial design and the optimum formula was selected. In vivo skin, deposition and cutaneous wound induction studies were performed for four groups of male wistar rats. At the end of the experiment, biochemical parameters were measured in the healed tissues (total proteins (TP), total antioxidant capacity (TAC), glutathione reductase (GSH), nitric oxide (NO), and malonaldehyde (MDA). Two in vivo histopathological experiments using male wistar rats were performed; the first study was done for the healed tissues of the above experiment and the second was to confirm the safety of formulations. Results: Qc optimum TFs (F6) showed EE% of 91.1%, PS of 695.35 nm, PDI of 0.592, and ZP of-11.1 mV, and spherical shape. In vivo skin deposition study showed that drug percentage retained in the skin from Qc optimum TFs was significantly higher than that from Qc suspension and Qc liposomes (p<0.05). There was no significant difference in the values of TP, TAC and MDA between the treated groups (p>0.05). GSH in TFs treated groups was significantly higher than the other groups (p<0.05) while NO in TFs treated groups was significantly lower than the other treated groups (p<0.05). Histopathological experiments showed that wounds treated by TFs healed better than those treated by both liposomes and Qc suspension. Conclusion: Qc-loaded TFs can be used as successful drug-delivery system for wound healing.

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Betamethasone Dipropionate Gel for Treatment of Localized Plaque Psoriasis

Cited by 18 publications

References 28 publications

Existing and Novel Therapies for Psoriasis

Existing and Novel Therapies for Psoriasis

Promising Strategies of Colloidal Drug Delivery-Based Approaches in Psoriasis Management

Topical Delivery of Quercetin Loaded Transfersomes for Wound Treatment: In Vitro and in Vivo Evaluation

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