Liposomes as a Tool to Study Lipid Peroxidation

Kaurinović, Biljana; Popović, Mira

doi:10.5772/46020

Cited by 5 publications

(4 citation statements)

References 77 publications

(75 reference statements)

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“…Since lipid peroxidation in the body is primarily the oxidative damage of cell membranes, as well as all other systems that contain lipids [21], in determining the overall antioxidant activity of different compounds, it is necessary (in addition to the antiradical assays) to examine their effect on the lipid peroxidation. The impact of various natural products (isolated compounds, extracts and essential oils) on lipid peroxidation can be studied in a number of different substrates (liposomes, linoleic acid, microsomes, various fatty oils, liver homogenate) [22]. Some substrates (liposomes and linoleic acid) are used more often than others primarily because of the simplicity of the method, but also because of easier dispersion in the investigated system compared to the fatty oil or microsome and hepatocytes isolation procedure.…”

Section: Resultsmentioning

confidence: 99%

Trifolium pratense L. as a Potential Natural Antioxidant

et al. 2014

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The essential oils of three different growth stages of Trifolium pratense L. (TP1, TP2 and TP3) were investigated by gas chromatography-mass spectrometry and tested for their antioxidant and antimicrobial activities. The highest content of volatile compounds was found in the essential oil sample TP1, where terpenes such as β-myrcene (4.55%), p-cymene (3.59%), limonene (0.86%), tetrahydroionone (1.56%) were highlighted due to their biological activity. The antioxidant activity was determined by following the scavenging capacity of the essential oils for the free radicals DPPH

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Section: Resultsmentioning

confidence: 99%

Trifolium pratense L. as a Potential Natural Antioxidant

et al. 2014

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“…On the other hand, different transition metal ions exhibit specific binding affinity to the flavonoids depending on their structure. For instance iron has the best binding affinity on ring C (C3-OH), ring B (catechol group) and ring A (C5-OH) while copper shows the best binding affinity on catechol containing flavonoids [91].…”

Section: Metal Chelating Activitymentioning

confidence: 99%

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

et al. 2015

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Glycation, the non-enzymatic binding of glucose to free amino groups of an amino acid, yields irreversible heterogeneous compounds known as advanced glycation end products. Those products play a significant role in diabetic complications. In the present article we briefly discuss the contribution of advanced glycation end products to the pathogenesis of diabetic complications, such as atherosclerosis, diabetic retinopathy, nephropathy, neuropathy, and wound healing. Then we mention the various mechanisms by which polyphenols inhibit the formation of advanced glycation end products. Finally, recent supporting documents are presented to clarify the inhibitory effects of polyphenols on the formation of advanced glycation end products. Phytochemicals apply several antiglycation mechanisms, including glucose metabolism, amelioration of oxidative stress, scavenging of dicarbonyl species, and up/down-regulation of gene expression. To utilize polyphenols in order to remedy diabetic complications, we must explore, examine and clarify the action mechanisms of the components of polyphenols.

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“…Thus, the most effective radical scavengers are flavonols with a catechol structure in the B ring (quercetin and its derivatives) [25]. The main structural features of flavonols also determine their antioxidant activity as chelators of transition metal ions (iron and copper), preventing the formation of oxidants and highly reactive hydroxyl radicals that can act, for example, as initiators of lipid peroxidation or lipoxygenase reactions [38]. There is a lot of convincing evidence that the activation of lipid peroxidation is a universal pathogenetic factor responsible for the onset and development of a wide range of diseases [34,39,40].…”

Section: Non-enzymatic Antioxidant Substances Of T Tetragonioidesmentioning

confidence: 99%

BIOACTIVE COMPOUNDS AND PHARMACOGNOSTIC POTENTIAL OF Tetragonia tetragonioides

Onoiko

2024

Biotechnol. acta

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In the recent years, due to the increasing resistance of pathogens to synthetic antimicrobial drugs, the use of highly active compounds from plants, which have proven their effectiveness in traditional medicine practices, is increased. Extracts of medicinal plants often contain a unique species ‒ specific combination of active ingredients that have a synergistic therapeutic effect. Therefore, the analysis of the biochemical composition of cultivated plants and the range of their potential biotechnological application is an urgent task. Aim. To summarize the information on the potential of the xerophytic plant Tetragonia tetragonioides as a source of functional food ingredients and biologically active substances that increase nonspecific organism resistance and contribute to the prevention and treatment of various diseases. Results. T. tetragonioides is a salt-tolerant and heat-resistant plant containing valuable nutrients and biologically active substances, a significant amount of vitamins, minerals, and dietary fibers. The high level of antioxidant compounds, especially flavonoids and carotenoids, helps to reduce the risk of degenerative pathologies developing associated with excessive oxidative stress. The unique complex of biologically active substances in T. tetragonioides, which includes 6-methoxyflavonols, predominantly derivatives of 6-methoxykaempferol, as well as megastigmanes and their glucosides, lignanamide, provides significant antioxidant, anti-inflammatory, antitumor, and antimicrobial activity and may be beneficial for the prevention of chronic diseases and age-related health problems. The effectiveness of T. tetragonioides has been demonstrated in animal models in the treatment of metabolic disorders such as obesity, hyperlipidemia, and hyperuricemia. Conclusions. T. tetragonioides, containing a specific complex of biologically active compounds, primarily 6-methoxyflavonols, may be a promising raw material for obtaining effective medications for the treatment and prevention of various chronic diseases and metabolic disorders.

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Liposomes as a Tool to Study Lipid Peroxidation

Cited by 5 publications

References 77 publications

Trifolium pratense L. as a Potential Natural Antioxidant

Trifolium pratense L. as a Potential Natural Antioxidant

The Mechanisms of Inhibition of Advanced Glycation End Products Formation through Polyphenols in Hyperglycemic Condition

BIOACTIVE COMPOUNDS AND PHARMACOGNOSTIC POTENTIAL OF Tetragonia tetragonioides

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