Liposomal gels for vaginal drug delivery

Pavelić, Željka; Škalko‐Basnet, Nataša; Schubert, Rolf

doi:10.1016/s0378-5173(01)00637-8

Cited by 156 publications

(59 citation statements)

References 21 publications

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“…Incorporation of vesicles in a gel can overcome these drawbacks but, unfortunately, may reduce drug release and accumulation in the different skin strata [9,10]. As an alternative, closely-packed semisolid phospholipid vesicles or gel core liposomes have been proposed as innovative tools for topical drug delivery [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring

et al. 2015

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“…This can be achieved by using dehydration-rehydration or freeze-thawing techniques. If the passive-loading protocols were applied, the liposome often entrapped a lower amount of hydrophilic substance (Pavelic, SB, & Schubert, 2001). Our CHEMS vesicles have high entrapment efficiencies as compared with phospholipid MLVs, suggesting that the CHEMS vesicle is likely a good carrier for water-solubility drug.…”

Section: Entrapment Efficiency Of Calcein By Chems Vesiclesmentioning

confidence: 89%

Preparation and Characterization of pH-Sensitive Vesicles Made of Cholesteryl Hemisuccinate

Xu¹,

Deng²,

Chen³

et al. 2008

Drug Development and Industrial Pharmacy

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pH-sensitive vesicles are designed to promote efficient release of entrapped agents in response to low pH. In this study, such vesicles were prepared from cholesteryl hemisuccinate (CHEMS) in Tris-HCl buffer. Vesicles prepared by this direct hydration method had a small particle size of 74.1 nm based on intensity of Gaussian and a size of 65.8 nm based on volume of Gaussian. The mean zeta potential was about -73mV, indicating that the vesicle system was stable. Entrapment efficiency for calcein by these vesicles was measured at 37 ± 2.36%, which is higher than that by phospholipid MLVs. These calcein loaded vesicles exhibited excellent stability at pH 7.4 and underwent rapid destabilization upon acidification as showed by calcein release. However these vesicles were unstable in Fetal Bovine Serum (FBS). Optimization of formulation might improve their stability in serum.

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“…Agarose method is another membrane-less diffusion model which allows to monitor the release of both the released drug and liposomally associated drug in environment simulating the conditions presented at the vaginal site [71].…”

Section: Membrane Diffusion Methodsmentioning

confidence: 99%