Liposomal form of lipoic acid: preparation and determination of antiplatelet and antioxidant activity

Shchelkonogov, V. A.; Сорокоумова, Г. М.; Baranova, O. A.; Чеканов, А. В.; Klochkova, A V; Kazarinov, K. D.; Solovieva, Elena; Федин, А. И.; Швец, В. И.

doi:10.18097/pbmc20166205577

Cited by 10 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The obtained data correlates well with that of Shchelkonogov et al. (2016) who obtained 85% inclusion of LA when phosphatidylcholine liposome was prepared using soy. Maiti et al.…”

Section: Resultssupporting

confidence: 90%

“…The decreased value in the current study could be owing to the competitive encapsulation of LA and CO in the nanoliposome. The obtained data correlates well with that of Shchelkonogov et al (2016) who obtained 85% inclusion of LA when phosphatidylcholine liposome was prepared using soy. Maiti et al (2007) reported 60% and 55% EE for α-tocopheryl-lipoic acid conjugates (TL1 and TL2) when nanovesicles were prepared for doxorubicin delivery.…”

Section: Co and La Contentsupporting

confidence: 88%

See 1 more Smart Citation

Liposomal encapsulation of omega‐3 fatty acid and α‐lipoic acid conjugate for cow milk fortification

Choudhary

Dutta

Moses

et al. 2021

Food Processing Preservation

View full text Add to dashboard Cite

The global interest in natural antioxidants has increased considerably in the recent past. Among many natural substances, α-lipoic acid (LA) and α-linolenic acid (ALA) have exhibited significant antioxidant and antiaging effects, under in vivo conditions (Argyropoulou et al., 2013). They are essential ω-3 polyunsaturated fatty acids that have well-known salutary effects. LA or 1, 2-dithiolane-3-pentanoic acid is generally found in meat muscles, fruits, and vegetables. LA is well known for its therapeutic benefits such as antioxidant activity, antidiabetic potency, remedial action in peripheral neuropathy, use in dermal care, and as an important geriatric supplement (through the restoration of depleting glutathione levels) (Salehi et al., 2019).Being a medically and nutritionally valued biomolecule, its predelivery, sustenance and site-specific delivery in the body are important aspects.ALA, an essential ω-3 polyunsaturated fatty acid, can also be supplemented in the human body only through diet. In vitro, in vivo, and clinical trials suggest beneficial effects of ω-3 fatty acids in healthcare.The benefits are diverse, including prevention and sometimes cure of cardiac and circulatory disorders, cognitive maladies, inflammatory diseases, and immune dysfunctions (Lavanya et al., 2019). Among all vegetable oils, chia seed oil (CO) contains approximately 68% ALA (Elshafie et al., 2018). Therefore, in the current study, chia oil has been

show abstract

“…The obtained data correlates well with that of Shchelkonogov et al. (2016) who obtained 85% inclusion of LA when phosphatidylcholine liposome was prepared using soy. Maiti et al.…”

Section: Resultssupporting

confidence: 90%

Section: Co and La Contentsupporting

confidence: 88%

Liposomal encapsulation of omega‐3 fatty acid and α‐lipoic acid conjugate for cow milk fortification

Choudhary

Dutta

Moses

et al. 2021

Food Processing Preservation

View full text Add to dashboard Cite

show abstract

“…На различных стадиях разработки находились и другие липосомальные препараты, среди которых можно упомянуть: цереброзидсульфат [59], глюкозаминглюкан, дексаметазон (офтальмологические препараты) [60,61], липосомальный яичный фосфатидилхолин (препарат для коррекции геморрагического шока) [62], липосомальный хлорофилипт (антибактериальный препарат) [63], липосомальная антиангиогенная фармацевтическая композиция на основе доксорубицина [64], дофамин (для лечения болезни Паркинсона) [65][66][67], рифампицин, изониазид, рифабутин (противотуберкулезные препараты) [68,69], липоевая кислота -препарат с антиагрегационной и антиоксидантной активностью [70], антихламидийный препарат с ресвератролом [71]. Следует отметить и другие результаты, полученные в области создания лекарственных липосомальных препаратов: противоопухолевый антибиотик гелиомицин [72], семакс -противоинсультный препарат [73], цефтриаксон -препарат для заживления ран [74], гонадотропин -препарат для лечения нарушения стероидогенеза [75], водорастворимые тетрапиррольные фотосенсибилизаторы для фотодинамической терапии [76], десферал -противохламидийный препарат [77], карбамазепин -препарат для лечения эпилепсии [78], цитохром С -кардиологический препарат [79].…”

Section: липосомальные лекарственные препараты на основе фосфолипидовunclassified

Scientific School of Academician Vitaly I. Shvets: Bionanopharmaceutical Technologies of Innovative Directed-Action Medicinal Preparations and Manpower Training

et al. 2017

View full text Add to dashboard Cite

The results of many years of scientific research in the field of physico-chemical biology and its most important direction - lipidology, conducted by the leading scientific school under the leadership of Academician RAS Vitaly I. Shvets, are reported. On the creation of synthetic, biotechnological methods for obtaining lipids, with the possibility of their practical use by designing on this basis effective diagnostic and medicinal products and application in practical medicine. The further development and use of methods of bionanotechnology for the development of modern medicines for directed action on the basis of increasing the effectiveness of classical drugs by their incorporation into nanocontainers is described. It is reported on the development of technologies for obtaining nanoscale forms of drugs, the study of their pharmacological properties and use in medical practice. Information is provided on the preparation of liposomal antitumor, hepatoprotective, anti-tuberculosis, cardiac preparations based on the proposed echnologies, the study of properties and the use for therapeutic purposes. The technologies for obtaining and conducting biological studies of nanoforms based on copolymers of lactic and glycolic acids of antineoplastic, anti-inflammatory, antibacterial and a number of other drugs have been developed: It has been shown that the use of nanosized drugs can lead to a significant increase in the pharmacological effect due to various factors. It was noted that during the construction of the drug for the treatment of Parkinson's disease, the contents of liposomes loaded with dopamine pass through the blood-brain barrier almost 100 times better than individual dopamine molecules. Finding a substance in nanoparticles reduces its toxicity primarily due to the effect of "passive targeting". The prolonged action of medicinal substances enclosed in nanoparticles is discussed, due to their gradual release. It is noted that the targeted delivery of nanoparticles makes it possible to increase the effectiveness of the drugs by an order of magnitude. It is reported on the drug-delivery technology in the field of oncology and the use of the method of selective delivery of cytostatics to tumor tissues using the receptor-mediated endocytosis. Biological and pharmacological studies based on nanopoporous silicon on the creation of liposomal drugs for the treatment of cancer, cardiological pathologies, tuberculosis are carried out. Data on the work of the scientific and educational center for training specialists in the field of biotechnology and pharmacy are given.

show abstract

Lipoic acid nanoforms based on phosphatidylcholine: production and characteristics

et al. 2019

View full text Add to dashboard Cite

Liposomal form of lipoic acid: preparation and determination of antiplatelet and antioxidant activity

Cited by 10 publications

References 7 publications

Liposomal encapsulation of omega‐3 fatty acid and α‐lipoic acid conjugate for cow milk fortification

Liposomal encapsulation of omega‐3 fatty acid and α‐lipoic acid conjugate for cow milk fortification

Scientific School of Academician Vitaly I. Shvets: Bionanopharmaceutical Technologies of Innovative Directed-Action Medicinal Preparations and Manpower Training

Lipoic acid nanoforms based on phosphatidylcholine: production and characteristics

Contact Info

Product

Resources

About