Liposarcoma of the larynx

Abstract

Liposarcomas of the larynx are very rare. Only nine cases appear to have been recorded in the English literature.An additional case of liposarcoma of the larynx occurring in a young patient is reported and the relevant literature discussed.

Liposarcoma of the Larynx

“…12,15,29 Dedifferentiated liposarcoma has a metastatic rate of approximately 15% and a recurrence rate of about 40%. 15,29 Low-grade variants (myxoid and well differentiated) have the best (80% to 100%) 5-year survival rates and the lowest rates of metastasis.…”

“…Postoperative irradiation has been shown to be a valuable adjunct to surgical therapy in the management of liposarcoma located in other parts of the body, 32,33 especially for the myxoid variant. [7][8][9][10][11][12] Another report, however, states that radiotherapy is unjustified, considering the favorable outcome of LLS with wide surgical excision alone. 34,35 Some authors advocate the use of radiotherapy for palliation or as adjuvant management with surgery.…”

Upper Aerodigestive Tract Liposarcoma: Report on Four Cases and Literature Review

“…For liposarcomas occurring in other areas of the body, radiation therapy has been shown to be a valuable adjunct to surgery, especially for the myxoid variant 28 . Radiation therapy has been used postoperatively in six of the cases of UADT liposarcoma reviewed 7,8,13‐15 . Some authors believe that, given the favorable outcome of liposarcomas of the larynx and hypopharynx with wide surgical excision alone, regardless of histologic type, adjuvant radiotherapy is unjustified 19 .…”

“…There have been 26 well‐documented English‐language case reports of laryngeal liposarcoma, 4‐20 the clinicopathologic features of which are presented in Table I, along with that of case 1 in this report. The mean patient age at presentation was 54.5 years (range, 28‐83 y) with a significant male predominance (male:female ratio of 24:3).…”

“…Primary liposarcomas of the upper aerodigestive tract (UADT) are rare entities. There have been only 26 cases of laryngeal liposarcoma, 4‐20 7 cases of hypopharyngeal liposarcoma, 15,19,21 and just 6 cases of esophageal liposarcoma 22‐27 that are well‐documented in the English‐language literature. We report on four patients with UADT liposarcoma.…”