Lipoprotein subfractions in patients with sarcopenia and their relevance to skeletal muscle mass and function

Gong, Hui; Liu, Yang; Lyu, Xing; Dong, Lini; Zhang, Xiangyu

doi:10.1016/j.exger.2021.111668

Cited by 27 publications

(22 citation statements)

References 44 publications

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“…3B, Table S1)(The pathways were obtained baising on KEGG [25][26][27]). We noticed that most of these biological processes were involved in serum lipoprotein metabolism and transport [28], suggesting that patients with sarcopenia might develop dyslipidemia, which was consistent with the study of Gong et al [29].…”

Section: Identification Of Sarcopenia-related Proteinssupporting

confidence: 91%

Characterization of serum protein expression profiles in the early sarcopenia older adults with low grip strength: a cross-sectional study

Cao

Wang

et al. 2022

BMC Musculoskelet Disord

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Background Sarcopenia refers to the progressive loss of skeletal muscle mass and muscle function, which seriously threatens the quality of life of the older adults. Therefore, early diagnosis is urgently needed. This study aimed to explore the changes of serum protein profiles in sarcopenia patients through a cross-sectional study, and to provide the reference for clinical diagnosis. Methods This study was a cross-sectional study carried out in the Tianjin institute of physical education teaching experiment training center from December 2019 to December 2020. Ten older adults were recruited, including 5 sarcopenia and 5 healthy older adults. After a detailed diagnostic evaluation, blood samples were collected to prepare serum for proteomic analysis using the HPLC System Easy nLC method. The differentially expressed proteins (DEPs) were screened by the limma package of R software (version 4.1.0). Results A total of 114 DEPs were identified between the patients and healthy older adults, including 48 up-regulated proteins and 66 down-regulated proteins. The functional enrichment analysis showed that the 114 DEPs were significantly enriched in 153 GO terms, which mainly involved in low-density lipoprotein particle remodeling, and negative regulation of immune response,etc. The PPI network further suggested that the cholesteryl ester transfer protein and Apolipoprotein A2 could serve as biomarkers to facilitate diagnosis of sarcopenia. Conclusions This study provided a serum proteomic profile of sarcopenia patients, and identified two proteins with diagnostic value, which might help to improve the diagnostic accuracy of sarcopenia.

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Section: Identification Of Sarcopenia-related Proteinssupporting

confidence: 91%

Characterization of serum protein expression profiles in the early sarcopenia older adults with low grip strength: a cross-sectional study

Cao

Wang

et al. 2022

BMC Musculoskelet Disord

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“…Sarcopenia is associated not only with loss of skeletal muscle function but also with alteration in carbohydrate and lipid metabolism especially when there is a concomitant condition of obesity (120). Overweight is often complicated by dyslipidemia, with increased serum levels of total cholesterol, fasting triglycerides (TG) and apolipoprotein B and decreased high-density lipoprotein cholesterol (HDL-C) (121).…”

Section: Sarcopenic Obesity: Role Of Muscle-fat Crosstalkmentioning

confidence: 99%

“…It has recently been shown that the loss of muscle mass is concomitant with fat mass gain (122). On the other hand, the type of dyslipidemia associated with sarcopenia in the elderly has not been yet adequately investigated or clearly defined (120). Serum TG and HDL-C concentrations have been shown to be independently associated with sarcopenic obesity (120).…”

Section: Sarcopenic Obesity: Role Of Muscle-fat Crosstalkmentioning

confidence: 99%

“…On the other hand, the type of dyslipidemia associated with sarcopenia in the elderly has not been yet adequately investigated or clearly defined (120). Serum TG and HDL-C concentrations have been shown to be independently associated with sarcopenic obesity (120). The evaluation of the lipid profile in a group of 84 elderly patients by measurement of multiple indices (total cholesterol TC, HDL-C and its intermediate HDL2, HDL3, low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), LDL-particles (LDL-P), lipoprotein(a) and remnant-like particle cholesterol (RLP-C) showed that the presence of sarcopenia was associated mainly with changes in VLDL and RLP-C.…”

Section: Sarcopenic Obesity: Role Of Muscle-fat Crosstalkmentioning

confidence: 99%

“…The evaluation of the lipid profile in a group of 84 elderly patients by measurement of multiple indices (total cholesterol TC, HDL-C and its intermediate HDL2, HDL3, low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), LDL-particles (LDL-P), lipoprotein(a) and remnant-like particle cholesterol (RLP-C) showed that the presence of sarcopenia was associated mainly with changes in VLDL and RLP-C. The authors suggest that increased skeletal muscle mass leads to improvements in energy metabolism by promoting triglyceride-rich lipoprotein hydrolysis through an increase in the circulating levels of lipoprotein lipase (LPL) and its correlated enzyme for lipolysis glycosylphosphatidylinositol anchored high-density lipoprotein binding protein 1 (GPIHBP1) and vice versa in conditions of decreased muscle mass (120).…”

Section: Sarcopenic Obesity: Role Of Muscle-fat Crosstalkmentioning

confidence: 99%

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Skeletal Muscle in Hypoxia and Inflammation: Insights on the COVID-19 Pandemic

et al. 2022

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SARS-CoV-2 infection is often associated with severe inflammation, oxidative stress, hypoxia and impaired physical activity. These factors all together contribute to muscle wasting and fatigue. In addition, there is evidence of a direct SARS-CoV-2 viral infiltration into skeletal muscle. Aging is often characterized by sarcopenia or sarcopenic obesity These conditions are risk factors for severe acute COVID-19 and long-COVID-19 syndrome. From these observations we may predict a strong association between COVID-19 and decreased muscle mass and functions. While the relationship between physical inactivity, chronic inflammation, oxidative stress and muscle dysfunction is well-known, the effects on muscle mass of COVID-19-related hypoxemia are inadequately investigated. The aim of this review is to highlight metabolic, immunity-related and redox biomarkers potentially affected by reduced oxygen availability and/or muscle fatigue in order to shed light on the negative impact of COVID-19 on muscle mass and function. Possible countermeasures are also reviewed.

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Presence of sarcopenia identifies a special group of lean NAFLD in middle-aged and older people

Zhu

Huang²,

Ma³

et al. 2022

Hepatol Int

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Lipoprotein subfractions in patients with sarcopenia and their relevance to skeletal muscle mass and function

Cited by 27 publications

References 44 publications

Characterization of serum protein expression profiles in the early sarcopenia older adults with low grip strength: a cross-sectional study

Characterization of serum protein expression profiles in the early sarcopenia older adults with low grip strength: a cross-sectional study

Skeletal Muscle in Hypoxia and Inflammation: Insights on the COVID-19 Pandemic

Presence of sarcopenia identifies a special group of lean NAFLD in middle-aged and older people

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