Lipoprotein Lipase Inhibition in the Hyperlipemia of Acute Alcoholic Pancreatitis

Kessler, Jacques I.; Kniffen, Jared C.; Janowitz, Henry D.

doi:10.1056/nejm196310312691803

Cited by 73 publications

(8 citation statements)

References 35 publications

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“…Some workers have found an acute decrease of PHLA and later normalization after the acute attack, while others have described the presence of PHLA inhibitors [15,36,37] and still others have found that PHLA was normal [6,24,38]. Some workers have found an acute decrease of PHLA and later normalization after the acute attack, while others have described the presence of PHLA inhibitors [15,36,37] and still others have found that PHLA was normal [6,24,38].…”

Section: Discussionmentioning

confidence: 99%

Hyperlipidemia and pancreatitis

Buch

Carlsen

et al. 1980

World j. surg.

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A total of 117 patients with pancreatitis were studied during the acute attack and after remission, and 32.5% were found to have hyperlipidemia, nearly all of type IV. There did not seem to be a relationship between hyperlipidemia and alcohol intake, although nearly 80% of the patients were alcoholics. No defect in triglyceride turnover could be demonstrated by intravenous fat tolerance tests or postheparin lipolytic activity measurements. No correlation was found between hyperlipidemia and steatosis of the liver or diabetes.It is suggested that the increase in serum triglyceride levels might be due to an increased synthesis or mobilization. It is also suggested that the hypertriglyceridemia does not directly induce an attack of pancreatitis, but might predispose a patient to develop pancreatitis when other provoking factors are also present.

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Section: Discussionmentioning

confidence: 99%

Hyperlipidemia and pancreatitis

Buch

Carlsen

et al. 1980

World j. surg.

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“…Other conditions reported to have low PHLA include diabetes mellitus (69), hormonal steroid treatment (43,46,70), liver disease (65), alcoholism (71), renal failure (72), and pancreatitis (73). Specific changes also might be detected with hypolipidemic diets or drugs found to increase total PHLA (44,45,74 …”

Section: Selective Measurement Of Two Lipase Activities In Postheparimentioning

confidence: 99%

Selective Measurement of Two Lipase Activities in Postheparin Plasma from Normal Subjects and Patients with Hyperlipoproteinemia

Krauss¹,

Levy²,

Fredrickson³

1974

J. Clin. Invest.

425

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A B S T R A C T An assay has been developed for specific measurement of two different lipase activities in postheparin plasma. Lipoprotein lipase, derived from extrahepatic sources, is measured as protamine-inactivated lipase activity; hepatic lipase activity is protamine-resistant under the conditions of this assay. In 100 normal subjects, both enzyme activities were noted to be related to age and sex. Protamine-resistant lipase, which comprised 46-95% of the total activity, was highest in men over 18. Protamine-inactivated lipase activity was greatest in younger males and was agecorrelated in women, doubling between the second and sixth decades.In 12 patients with hyperchylomicronemia, including five previously shown to have familial type I hyperlipoproteinemia, protamine-inactivated lipase activity was markedly reduced, whereas protamine-resistant lipase was below normal in only 1. The results were not due to lack of plasma activator, presence of plasma inhibitor, or diet, and the deficiency was not overcome by increasing the provoking dose of heparin from 10 U to 75 U/kg. Mean values for both lipase activities were not reduced in 32 other patients with hyperchylomicronemia, nine with "floating beta" lipoproteins (type III hyperlipoproteinemia), and 23 with hyperprebetalipoproteinemia (type IV). Mean protamine-resistant lipase activity was below normal in a group of four women with hypothyroidism, in whom protamine-inactivated lipase was not reduced. Both of the lipase activities were capable of hydrolyzing lipid in very low-density lipoproteins, but the relative rate of hydrolysis of chylomicrons by protamine-resistant lipase was markedly limited. These results indicate the importance of distinguishing between lipases of hepatic and extra-

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“…Dans les 19 cas. où elle fut pratiquée en phase suffisante d'hyperlipidémie, l'anomalie constante fut l'augmentation massive des pré-/(-lipoprotéines.…”

Section: Tests Tv Identification Des Lipoprotéinesunclassified

“…Moreover, demonstration of lipid anomalies in the relatives of 11 cases out of 15 suggests a genetic predisposition rather analogous to that in carbohydrate hyperlipemia. Treatment by simple withdrawal of alcohol is always effective, but very unreliably adhered to by these patients.L'augmentation des lipides plasmatiques en association avec l'alcoolisme, connue de longue date [8] a été signalée dans des publications récentes [2,4,6,11,16,17,19,20,[22][23][24][25][26][27]29] …”

mentioning

confidence: 99%

Hyperlipémies dépendantes de l’alcool

Gennes¹,

Thomopoulos²,

Truffert³

et al. 1972

Ann Nutr Metab

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The authors report a study of 28 cases of hyperlipemia due to alcohol. Clinically, they emphasize the predominance of the male sex, the high incidence of digestive disturbances, weight loss and hepatomegaly and the rarity of cardiovascular involvement. From the biochemical point of view, the majority of cases present an endogenous hyperlipemia of the same type as that induced by carbohydrates. Attention is also drawn to the disturbed glucose balance and the frequent hyperuricemia. Moreover, demonstration of lipid anomalies in the relatives of 11 cases out of 15 suggests a genetic predisposition rather analogous to that in carbohydrate hyperlipemia. Treatment by simple withdrawal of alcohol is always effective, but very unreliably adhered to by these patients.

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Lipoprotein Lipase Inhibition in the Hyperlipemia of Acute Alcoholic Pancreatitis

Cited by 73 publications

References 35 publications

Hyperlipidemia and pancreatitis

Hyperlipidemia and pancreatitis

Selective Measurement of Two Lipase Activities in Postheparin Plasma from Normal Subjects and Patients with Hyperlipoproteinemia

Hyperlipémies dépendantes de l’alcool

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