Lipomatous variant of angiomyofibroblastoma on the vulva: A case report

Abstract

Lipomatous variant of angiomyofibroblastoma is a rare tumor of the vulva. Most of cases are usually premenopausal and present with a slowly growing mass without pain. A 46-year-old woman presented with a swelling of the left labium major. The lesion was thought to be a Batholin's gland cyst or a lipoma preoperatively and a local excision was performed. The tumor was well demarcated and rubbery. On microscopic examination, the alternating hypercellular and edematous hypocellular component with abundant vessels was noted. A large amount of adipose tissue was scattered in the lesion. Stromal cells were positive for vimentin, estrogen receptor, and progesterone receptor and negative for desmin antibody immunostaining. The local excision was enough for complete treatment. No recurrence was noted for 7 months after surgery. Case ReportA 46-year-old woman, gravida 1 para 1, presented with a 2-year history of a swelling of the left vulva.The lesion had slowly increased in size. On gross examination the mass was easily movable, not adhered to adjacent tissue, and the size was 4×3×2 cm (Fig. 1A). On computed tomography (CT), highly enhanced mass was noted on the left vulva (Fig. 1B). On ultrasonogram, 4.2 cm sized subserosal myoma of the uterus and 2.2 cm sized right ovary cyst were noted. An

Lipomatous angiomyofibroblastoma of the vulva: A case report and review of the literature

“…In AMF, the tumor cells are strongly and diffusely positive for desmin, although such positivity may be reduced or absent in postmenopausal patients (1). However, excluding cases without distinct information, no desmin reactivity was observed in 5 (71%) of 7 patients with lipomatous AMF aged <50 years (8)(9)(10)(11)(12)14), which was unlike the typical AMF characteristics. In the present case, the tumor cells were also negative for desmin, and the cytoplasmic intermediate filaments were considered to be vimentin.…”

“…However, AMFs with a prominent fatty component are extremely rare. To the best of our knowledge, only 16 cases have been reported in the English literature to date (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15), and such tumors have been referred to as ῾lipomatous variants of AMF' (2,6,(9)(10)(11)14,15), which was first termed by Laskin et al (6), or ῾lipomatous AMF' (7,12,13). We herein present another pertinent case to expand our understanding of lipomatous AMF.…”

Lipomatous variant of angiomyofibroblastoma: a case report and review of the literature

“…Only eight reports in the English language literature describe this variant in detail (Table ). Seven tumors occurred in the vulva, and one in the inguino‐scrotal region of a man . We describe a further tumor characterized by prominent lipomatous change comprising approximately 60% of the lesion.…”

“…A minor lipomatous component may occur, but there are only rare reports in which a lipomatous component comprised a substantial part of the lesion. This variant has been designated the lipomatous variant of angiomyofibroblastoma, with only eight cases reported in detail . We describe a further example of angiomyofibroblastoma of the vulva characterized by abundant mature adipose tissue that comprised the greater portion of the tumor.…”

Lipomatous Variant of Angiomyofibroblastoma Involving the Vulva

“…Lipomatous tumors are, in general, rare in the vulva and vagina (6). Lipomatous tumors are, in general, rare in the vulva and vagina (6).…”