Lipomatous angiomyofibroblastoma of the vulva: A case report and review of the literature

Matsukuma, Susumu; Koga, Ayano; Suematsu, Ryohei; Takeo, Hiroaki; Sato, Kimiya

doi:10.3892/mco.2016.1078

Cited by 8 publications

(5 citation statements)

References 15 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…8 Many times, the tumour is discovered incidentally when the patient is being investigated for some other reasons. 9 The diagnosis is confirmed on clinical course, imaging studies and HPE. 10 Treatment depends on the location, clinical manifestation of the condition and site and size of the growth.…”

Section: Discussionmentioning

confidence: 82%

Angiomyolipoma of vulva: Rare tumour at an unusual site

Kathpalia

Sharma

Yadav

et al. 2020

Medical Journal Armed Forces India

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 82%

Angiomyolipoma of vulva: Rare tumour at an unusual site

Kathpalia

Sharma

Yadav

et al. 2020

Medical Journal Armed Forces India

View full text Add to dashboard Cite

“…A lipomatous variant of AMF with presence of adipocytes ≥ 30% and possible sarcomatous transformation was also described. The pleomorphic lipoblasts present S100 positivity and do not display positivity for ER [12, 13].…”

Section: Discussionmentioning

confidence: 99%

Angiomyofibroblastoma mimicking an inguinal hernia: a challenging diagnosis in a male patient

Banias

Gurzu

Jung

et al. 2019

pdia

View full text Add to dashboard Cite

Introduction Angiomyofibroblastoma is a rare benign myofibroblastic neoplasm which mainly occurs in the soft tissues of the pelvi-perineal region of females. Aim To present an unusual case of angiomyofibroblastoma mimicking an inguinal hernia in a 62-year-old male. Material and methods The patient was hospitalized with an irreducible, painless inguinal mass and surgical intervention for inguinal hernia was decided. The well-defined nodular mass was sent for histological examination. Results Under microscope, proliferation of spindle and oval cells around thin-walled vessels was observed, being intermingled with mature adipocytes. We did not identify necrosis, haemorrhage, cytologic atypia or mitotic figures. The tumour cells displayed positivity for desmin, vimentin, CD34, oestrogen and progesterone receptors, a low Ki67 index and unusual nuclear positivity for c-theta (PKCθ). They were negative for smooth muscle actin (SMA), S100, CD44, maspin, synaptophysin, DOG1 and CD117. The case was diagnosed as angiomyofibroblastoma, the main challenge being the differential diagnosis with aggressive angiomyxoma, which can present a similar histologic aspect and immunophenotype and recurs more frequently. No recurrences were observed 8 months after the surgery. Conclusions Angiomyofibroblastoma should be included in the differential diagnosis of inguinal hernia. This is the fourteenth case of angiomyofibroblastoma diagnosed in males.

show abstract

“…blood-filled, pseudo-angiomatoid, cystic spaces resembling an angiomatoid fibrous histiocytoma [ 46 ]…”

Section: Figurementioning

confidence: 99%

Practical Approach to the Diagnosis of the Vulvo-Vaginal Stromal Tumors: An Overview

et al. 2022

View full text Add to dashboard Cite

Background: The category of the “stromal tumors of the lower female genital tract” encompasses a wide spectrum of lesions with variable heterogeneity, which can be nosologically classified on the basis of their morphologic and immunohistochemical profiles as deep (aggressive) angiomyxoma (DAM), cellular angiofibroma (CAF), angiomyofibroblastoma (AMFB) or myofibroblastoma (MFB). Despite the differential diagnosis between these entities being usually straightforward, their increasingly recognized unusual morphological variants, along with the overlapping morphological and immunohistochemical features among these tumours, may raise serious differential diagnostic problems. Methods and Results: The data presented in the present paper have been retrieved from the entire published literature on the PubMed website about DAM, CAF, AFMB and MFB from 1984 to 2021. The selected articles are mainly represented by small-series, and, more rarely, single-case reports with unusual clinicopathologic features. The present review focuses on the diagnostic clues of the stromal tumours of the lower female genital tract to achieve a correct classification. The main clinicopathologic features of each single entity, emphasizing their differential diagnostic clues, are discussed and summarized in tables. Representative illustrations, including the unusual morphological variants, of each single tumour are also provided. Conclusion: Awareness by pathologists of the wide morphological and immunohistochemical spectrum exhibited by these tumours is crucial to achieve correct diagnoses and to avoid confusion with reactive conditions or other benign or malignant entities.

show abstract

Lipomatous angiomyofibroblastoma of the vulva: A case report and review of the literature

Cited by 8 publications

References 15 publications

Angiomyolipoma of vulva: Rare tumour at an unusual site

Angiomyolipoma of vulva: Rare tumour at an unusual site

Angiomyofibroblastoma mimicking an inguinal hernia: a challenging diagnosis in a male patient

Practical Approach to the Diagnosis of the Vulvo-Vaginal Stromal Tumors: An Overview

Contact Info

Product

Resources

About