Lipomatous variant of angiomyofibroblastoma: a case report and review of the literature

Upreti, Sheela; Morine, Angela; Ng, Daniel K.; Bigby, Susan M.

doi:10.1111/cup.12450

Cited by 8 publications

(6 citation statements)

References 16 publications

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“…In AMF, the tumor cells are strongly and diffusely positive for desmin, although such positivity may be reduced or absent in postmenopausal patients (1). However, excluding cases without distinct information, no desmin reactivity was observed in 5 (71%) of 7 patients with lipomatous AMF aged <50 years (8)(9)(10)(11)(12)14), which was unlike the typical AMF characteristics. In the present case, the tumor cells were also negative for desmin, and the cytoplasmic intermediate filaments were considered to be vimentin.…”

Section: Discussionmentioning

confidence: 88%

“…However, AMFs with a prominent fatty component are extremely rare. To the best of our knowledge, only 16 cases have been reported in the English literature to date (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15), and such tumors have been referred to as ῾lipomatous variants of AMF' (2,6,(9)(10)(11)14,15), which was first termed by Laskin et al (6), or ῾lipomatous AMF' (7,12,13). We herein present another pertinent case to expand our understanding of lipomatous AMF.…”

Section: Introductionmentioning

confidence: 99%

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Lipomatous angiomyofibroblastoma of the vulva: A case report and review of the literature

Matsukuma¹,

Koga²,

Suematsu³

et al. 2016

Molecular and Clinical Oncology

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Abstract. Lipomatous angiomyofibroblastoma is extremely rare, with only 16 cases reported to date. We herein describe an additional case arising in the left vulvar region of a 49-year-old woman. The resected 5.3-cm yellowish tumor predominantly consisted of fat cells (85% of the tumor), together with medium-and small-sized vessels, multifocal fibrotic areas and pseudoangiomatous spaces. Spindle, rounded, and/or epithelioid tumor cells proliferated in a nest and/or cord-like pattern, or singly within perivascular fibrous tissues and between fat cells. The tumor cells were positive for vimentin, estrogen receptor, progesterone receptor, B-cell lymphoma 2, and CD10, but were negative for desmin, cytokeratin, epithelial membrane antigen, S-100 protein, human melanoma black 45, C-kit and p40. Ultrastructural examination revealed that these tumor cells exhibited fibroblastic characteristics. Lipomatous angiomyofibroblastoma should be discriminated from other lipomatous tumors, including spindle cell lipoma, angiomyolipoma and cellular angiofibroma containing numerous fat cells.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Lipomatous angiomyofibroblastoma of the vulva: A case report and review of the literature

Matsukuma¹,

Koga²,

Suematsu³

et al. 2016

Molecular and Clinical Oncology

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“…Histologically, as its name suggests, the two main striking features of AMFB are a population of cells with a fibroblastic/myofibroblastic profile and a well-represented vascular component. Histologically, AMFB is a well-circumscribed, unencapsulated or partially/totally encapsulated tumour showing alternating hypocellular and hypercellular areas [ 32 , 33 , 34 , 35 ] ( Table 5 ); it is composed of a proliferation of bland-looking spindled-to-epithelioid cells, arranged singly or in small nests or cords ( Figure 6 A–D) that tend to be clustered around blood vessels ( Figure 6 B,E). The epithelioid/plasmacytoid morphology is best appreciated in the hypercellular areas; a predominant spindle-cell morphology is more frequently observed in postmenopausal patients.…”

Section: Resultsmentioning

confidence: 99%

Practical Approach to the Diagnosis of the Vulvo-Vaginal Stromal Tumors: An Overview

et al. 2022

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Background: The category of the “stromal tumors of the lower female genital tract” encompasses a wide spectrum of lesions with variable heterogeneity, which can be nosologically classified on the basis of their morphologic and immunohistochemical profiles as deep (aggressive) angiomyxoma (DAM), cellular angiofibroma (CAF), angiomyofibroblastoma (AMFB) or myofibroblastoma (MFB). Despite the differential diagnosis between these entities being usually straightforward, their increasingly recognized unusual morphological variants, along with the overlapping morphological and immunohistochemical features among these tumours, may raise serious differential diagnostic problems. Methods and Results: The data presented in the present paper have been retrieved from the entire published literature on the PubMed website about DAM, CAF, AFMB and MFB from 1984 to 2021. The selected articles are mainly represented by small-series, and, more rarely, single-case reports with unusual clinicopathologic features. The present review focuses on the diagnostic clues of the stromal tumours of the lower female genital tract to achieve a correct classification. The main clinicopathologic features of each single entity, emphasizing their differential diagnostic clues, are discussed and summarized in tables. Representative illustrations, including the unusual morphological variants, of each single tumour are also provided. Conclusion: Awareness by pathologists of the wide morphological and immunohistochemical spectrum exhibited by these tumours is crucial to achieve correct diagnoses and to avoid confusion with reactive conditions or other benign or malignant entities.

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“…The term cellular angio ibroma was chosen to emphasize the both components. These tumors are almost always positive with estrogen and progesterone receptors, suggesting they probably arise from the hormone receptor positive [4][5][6][7][8].…”

Section: Discussionmentioning

confidence: 99%

Giant cellular angiofi broma of the vulva: case report

Ribeiro¹,

Ferreira²,

Ramos³

2019

Clin J Obstet Gynecol.

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Cellular Angiofi broma is a rare benign mesenchymal tumor without gender preference. It is usually a small (<3cm), well-circumscribed, mostly asymptomatic and typically slow growing. Surgical removal of the mass with its capsule is the preferred treatment, not only helps guarantee complete excision and prevent its recurrence but also minimize blood loss. We present the case of a 76-year-old woman with a giant vulvar mass.

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Lipomatous variant of angiomyofibroblastoma: a case report and review of the literature

Cited by 8 publications

References 16 publications

Lipomatous angiomyofibroblastoma of the vulva: A case report and review of the literature

Lipomatous angiomyofibroblastoma of the vulva: A case report and review of the literature

Practical Approach to the Diagnosis of the Vulvo-Vaginal Stromal Tumors: An Overview

Giant cellular angiofi broma of the vulva: case report

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