Lipoic acid: A multifunctional antioxidant

Bast, Aalt; Haenen, Guido R.M.M.

doi:10.1002/biof.5520170120

Cited by 156 publications

(114 citation statements)

References 9 publications

(5 reference statements)

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“…The disulfide in LA is in a dithiolane, a five-membered ring, with a dihedral angle of 35°. This constellation results in an energetically unfavorable interaction of the orbital of the lone p z electron pairs of the sulfur atoms that in turn exerts a high energy content of the disulfide group of LA with oxidizing species (29). Because of this potent hydroxyl scavenger and chelating potential, LA has gained a salutatory role as a food supplement and in the treatment of several clinical conditions such as Amanita mushroom poisoning (30), diabetic neuropathy (31), Alzheimer disease (11), Parkinson disease (12), and multiple sclerosis (13).…”

Section: Discussionmentioning

confidence: 99%

Interaction of α-Lipoic Acid with the Human Na+/Multivitamin Transporter (hSMVT)

Zehnpfennig

Wiriyasermkul

Carlson

et al. 2015

Journal of Biological Chemistry

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Background: Transport of ␣-lipoate by hSMVT and its stereospecificity have been elusive. Results: Using hSMVT expressed in oocytes and in Pichia pastoris yielded detailed information about the stereospecificity of hSMVT-mediated lipoate transport and binding. Conclusion: hSMVT can bind two molecules of R-(ϩ)-␣-lipoate, its physiological substrate.Significance: In addition to biotin, pantothenate, and iodide, hSMVT mediates the transport of lipoate.

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Section: Discussionmentioning

confidence: 99%

Interaction of α-Lipoic Acid with the Human Na+/Multivitamin Transporter (hSMVT)

Zehnpfennig

Wiriyasermkul

Carlson

et al. 2015

Journal of Biological Chemistry

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“…), and lycopene (tomatoes, grapefruit), which are present in foods that we consume daily, are antioxidants used for this purpose [2,3,26] . α-LA, which we used in our study, is a natural antioxidant found in broccoli, spinach, tomatoes, and kidney, liver, and heart tissue from animal products [11] . It has a dithiolane ring.…”

Section: Discussionmentioning

confidence: 99%

“…Besides being a potent antioxidant, α-LA is a cofactor for mitochondrial enzymes, metal chelator, and free radical scavenger [10] . It directly and indirectly regenerates ascorbate, coenzyme Q10, glutathione, and vitamin E [11] . α-LA is both lipid-and water-soluble, in contrast to lipid-soluble vitamin E and water-soluble vitamin C. With all of these features, α-LA is an antioxidant agent that is close to ideal.…”

Section: Discussionmentioning

confidence: 99%

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The Protective Effect of Intratympanic Alpha Lipoic Acid on Cisplatin-Induced Ototoxicity on Rats

Altıntoprak¹,

Aydın²,

Şanlı³

et al. 2015

Int Adv Otol

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OBJECTIVE:The objective of this study is to investigate the effect of intratympanic alpha lipoic acid (α-LA) on cisplatin-induced ototoxicity by using distortion product otoacoustic emission (DPOAE). MATERIALS and METHODS:A total of 24 Wistar albino rats were randomly divided into three groups: group 1 received intraperitoneal (IP) saline + intratympanic (IT) saline as a control group for 4 days (n=8), group 2 received IP cisplatin (20 mg/kg) + IT saline (0.1-0.3 mL) for 4 days (n=8), and group 3 received IP cisplatin (20 mg/kg) + IT α-LA (25 mg/mL) for 4 days (n=8). DPOAEs were performed prior to the procedure and at the end of the experiment on day 5. RESULTS:Statistically significant DPOAE amplitude reductions were found in the group 2 at all frequencies (2-9 kHz) that demonstrate severe cisplatin ototoxicity (p<0.01). IT α-LA injection provided a protective effect against cisplatin-induced ototoxicity at 3.2, 3.8, 4.5, 5.4, 6.3, and 7.6 kHz frequencies (p<0.05). CONCLUSION:In our study IT α-LA showed a protective effect against cisplatin-induced ototoxicity in a large frequency range.

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“…Its antioxidant properties give it the ability to scavenge reactive oxygen species (ROS), both in hydrophilic and in lipophilic media (Bast and Haenen, 2003). In addition, α-LA has the ability to regenerate endogenous antioxidants, including vitamins C and E, as well as intracellular GSH (Maczurek et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Anti-Oxidative Role Of Lipoic Acid Against Lead-Induced Hepatic Toxicity In Japanese Quails

Ismail¹,

Taha²,

Mandour³

et al. 2017

AJVS

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Key words:Quails; Lead; Lipoic acid; Antioxidant; Malondialdehyde, Copper Quails are exposed to deleterious doses of lead from different sources which decrease the bird performance, and growth with economic loses. This work aimed to explore the antioxidative effect of alpha lipoic acid to counteract the adverse effects of lead in Japanese quails. Forty Japanese quails with both sex were grouped into control, lead acetate (100 ppm in drinking water), alpha lipoic acid (1 g/kg diet), and the final group which received both lipoic acid and lead acetate of the same doses. Lead acetate significantly increased the liver enzymatic biomarkers (ALT, AST, and ALP), and bilirubin levels with decline in the serum total protein and albumin concentrations. Also, lead, copper concentrations in liver tissue were significantly increased with decreased hepatic iron level and serum calcium and phosphorus levels following lead acetate administration. Moreover, lead significantly increased hepatic malondialdehyde level with attenuation of antioxidant enzymes; GPX, GST, CAT, and SOD activities and nonenzymatic antioxidant; GSH concentration. Co-administration of alpha-lipoic acid together with lead acetate significantly improved the liver functions, increased the antioxidant activities, and corrected the serum and hepatic major and trace element concentrations without any effect on hepatic lead level. Our results suggested that alpha lipoic acid can counteract the deleterious effects of lead in quails through attenuation of oxidative stress and enhancement of antioxidative capacity in liver tissues.Correspondence to:

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Lipoic acid: A multifunctional antioxidant

Cited by 156 publications

References 9 publications

Interaction of α-Lipoic Acid with the Human Na+/Multivitamin Transporter (hSMVT)

Interaction of α-Lipoic Acid with the Human Na+/Multivitamin Transporter (hSMVT)

The Protective Effect of Intratympanic Alpha Lipoic Acid on Cisplatin-Induced Ototoxicity on Rats

Anti-Oxidative Role Of Lipoic Acid Against Lead-Induced Hepatic Toxicity In Japanese Quails

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