Lipodystrophy, lipid profile changes, and low serum retinol and carotenoid levels in children and adolescents with acquired immunodeficiency syndrome

Battistini, Tânia Regina Beraldo; Sarni, Roseli Oselka Saccardo; Souza, Fabíola Isabel Suano de; Pitta, Tassiana Sacchi; Fernandes, Ana Paula; Hix, Sonia; Fonseca, Fernando Luiz Affonso; Tardini, Priscila Chemiotti; Santos, Valter Pinho dos; Lopez, Fábio Ancona

doi:10.1016/j.nut.2009.06.024

Cited by 17 publications

(9 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although definitions of retinol deficiency vary across studies, reports of retinol deficiency in preschool children show rates up to 74.5% in Brazil, 30% in Argentina and 46% in Mexico 21. This study supports the idea of poor intake as the main cause for the high prevalence of retinol deficiency 22.…”

Section: Discussionsupporting

confidence: 78%

Nutritional status and lipid profile of HIV-positive children and adolescents using antiretroviral therapy

Contri

Berchielli²,

Tremeschin³

et al. 2011

Clinics

View full text Add to dashboard Cite

OBJECTIVE:To describe nutritional status, body composition and lipid profile in children and adolescents receiving protease inhibitors.METHODS:Fifty-nine patients, 23 treated with protease inhibitors (group 1) and 36 not using protease inhibitors (group 2). Their dietary intake, anthropometry, bioimpedance analysis and lipid profile variables were measured.RESULTS:There was no difference in nutritional status or body composition between groups at the beginning of the study. After 6 months of follow-up, there was an increase in weight and height in both groups, as well as in waist circumference and subscapular skinfold thickness. In group 2, body mass index and triceps skinfold thickness adequacy were significantly higher after 6 months of follow-up. The groups had similar energy and macronutrient intake at any time point. After 6 months, group 1 had a higher cholesterol intake and group 2 had a higher fiber intake. Triglyceride serum levels were significantly different between the groups, with higher values in G1, at any time point [G1: 153 mg/dl (30–344); 138 (58–378) versus G2: 76 mg/dl (29–378); 76 (29–378)]. After 6 months of follow-up, G1 had higher LDL-cholesterol than G2 [104 mg/dl (40–142) versus 82 (42–145)].CONCLUSION:The use of protease inhibitors, per se, does not seem to significantly interfere with anthropometric measures, body composition and food intake of HIV-infected children and adolescents. However, this antiretroviral therapy was associated with a significant increase in triglyceride and LDL-cholesterol in our subjects.

show abstract

Section: Discussionsupporting

confidence: 78%

Nutritional status and lipid profile of HIV-positive children and adolescents using antiretroviral therapy

Contri

Berchielli²,

Tremeschin³

et al. 2011

Clinics

View full text Add to dashboard Cite

show abstract

“…The metabolic features include at least one of the following: fasting hypertriglyceridemia and/or hypercholesterolemia, fasting C-peptide level elevation and evidence of abnormal glucose metabolism, including disorders ranging from abnormal fasting glucose levels to diabetes mellitus [2][3][4] . Although published studies have yielded valuable data on the characterization of lipodystrophy syndrome and metabolic changes and its association with PI-containing antiretroviral therapy among children and adolescents worldwide, very little data exist in Brazil concerning nutritional status, quality of life and lipid profile 5,6 after one year of HAART.…”

Section: Introductionmentioning

confidence: 99%

Nutritional assessment and lipid profile in HIV-infected children and adolescents treated with highly active antiretroviral therapy

Tremeschin

Sartorelli

Cervi

et al. 2011

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

Introduction: HIV-infected children and adolescents treated with highly active antiretroviral therapy (HAART) regimens that include a protease inhibitor (PI) can show significant improvements in clinical outcomes, nutritional status and quality of life. The study aimed to report nutritional and metabolic alterations for pediatric patients continuously exposed to HAART and for healthy controls for up to 1 year. Methods: Clinical, anthropometric, lipid profile and food intake data were collected prospectively over approximately 12-months for each patient. Results: Fifty-one individuals were studied, of these, 16 were healthy. After 12 months followup, HIV-positive individuals remained below the healthy control group parameters. No change was observed concerning food intake. Triglyceride serum levels were higher in patients using protease inhibitor at the onset of the study , and 136 (63 -271) versus control group: 54.5 (20 -162); p = 0.003], but after twelve months follow-up, only the group using protease inhibitor for up to two months presented higher values [140 (73 -273)

show abstract

“…Older age is typically associated with an increased incidence of metabolic abnormalities and CVDs in the general population. Some recent studies with a cross-sectional design found that children and adolescents on ART had a high rate of recurrence of dyslipidemia [129][130][131]. Adolescents and younger children are more susceptible to metabolic alterations compared with adults, since their organs are still developing and they are exposed to antiretroviral medications for a longer period [64].…”

Section: Dyslipidemia and Pismentioning

confidence: 99%

Metabolic Abnormalities in HIV-Infected Populations without or with Antiretroviral Therapy (ART)

Hejazi

Rajikan

2015

Health of HIV Infected People

View full text Add to dashboard Cite

Lipodystrophy, lipid profile changes, and low serum retinol and carotenoid levels in children and adolescents with acquired immunodeficiency syndrome

Cited by 17 publications

References 38 publications

Nutritional status and lipid profile of HIV-positive children and adolescents using antiretroviral therapy

Nutritional status and lipid profile of HIV-positive children and adolescents using antiretroviral therapy

Nutritional assessment and lipid profile in HIV-infected children and adolescents treated with highly active antiretroviral therapy

Metabolic Abnormalities in HIV-Infected Populations without or with Antiretroviral Therapy (ART)

Contact Info

Product

Resources

About