Lipids in Oral Controlled Release Drug Delivery

Boyd, Ben J.; Nguyen, Tri‐Hung; Müllertz, Anette

doi:10.1007/978-1-4614-1004-1_15

Cited by 8 publications

(5 citation statements)

References 128 publications

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“…It was known that waxes did not dissolve well in gastrointestinal media [ 11 ] and these data confirm data in the literature. Waxes can still be used in pharmaceutical applications to slow the delivery systems; in these instances, since waxes do not dissolve to rapidly release the compounds and slow release occurring by simple diffusion [ 11 , 20 ], presumably, in food systems, this could be useful for the slow release of omega-3 oils and lipophilic vitamins (A, D, E, or K) in the food itself or in the GIT.…”

Section: Discussionsupporting

confidence: 88%

“…However, waxes could be considered for very slow release of functional oils (omega-3 or omega-6 oils) in the duodenum. Indeed, the oils could simply diffuse outside the wax particle without requiring breakdown of the wax matrix as is done in some pharmaceutical applications [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…Palm kernel oil has been suggested as a matrix for spray chilling [ 9 ] and chocolate is now recognized as a good carrier for probiotics [ 10 ]. The pharmaceutical industry also uses waxes for the controlled release of bioactives [ 11 ], but there are no comparative studies of their dissolution in the GIT environments in comparison to chocolate or oils.…”

Section: Introductionmentioning

confidence: 99%

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Dissolution of Lipid-Based Matrices in Simulated Gastrointestinal Solutions to Evaluate Their Potential for the Encapsulation of Bioactive Ingredients for Foods

Raymond

Champagne

2014

International Journal of Food Science

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The goal of the study was to compare the dissolution of chocolate to other lipid-based matrices suitable for the microencapsulation of bioactive ingredients in simulated gastrointestinal solutions. Particles having approximately 750 μm or 2.5 mm were prepared from the following lipid-based matrices: cocoa butter, fractionated palm kernel oil (FPKO), chocolate, beeswax, carnauba wax, and paraffin. They were added to solutions designed to simulate gastric secretions (GS) or duodenum secretions (DS) at 37°C. Paraffin, carnauba wax, and bees wax did not dissolve in either the GS or DS media. Cocoa butter, FPKO, and chocolate dissolved in the DS medium. Cocoa butter, and to a lesser extent chocolate, also dissolved in the GS medium. With chocolate, dissolution was twice as fast as that with small particles (750 μm) as compared to the larger (2.5 mm) ones. With 750 μm particle sizes, 90% dissolution of chocolate beads was attained after only 60 minutes in the DS medium, while it took 120 minutes for 70% of FPKO beads to dissolve in the same conditions. The data are discussed from the perspective of controlled release in the gastrointestinal tract of encapsulated ingredients (minerals, oils, probiotic bacteria, enzymes, vitamins, and peptides) used in the development of functional foods.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dissolution of Lipid-Based Matrices in Simulated Gastrointestinal Solutions to Evaluate Their Potential for the Encapsulation of Bioactive Ingredients for Foods

Raymond

Champagne

2014

International Journal of Food Science

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“…Similar to surfactants, some amphiphilic polar lipids self-assemble in the presence of water to form liquid crystals. Different liquid crystalline phases such as lamellar, hexagonal and cubic phases are formed depending on the structure and composition of lipid, composition on the water and external conditions like temperature and pressure [83].…”

Section: 𝐶𝑃𝑃 = 𝑣/𝑎𝑙mentioning

confidence: 99%

Conducting polymers with defined micro- or nanostructures for drug delivery

Uppalapati

Boyd²,

Garg

et al. 2016

Biomaterials

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Conducting polymers (CPs) are redox active materials with tunable electronic and physical properties. The charge of the CP backbone can be manipulated through redox processes, with accompanied movement of ions into and out of the polymer to maintain electrostatic neutrality. CPs with defined micro- or nanostructures have greatly enhanced surface areas, compared to conventionally prepared CPs. The resulting high surface area interface between polymer and liquid media facilities ion exchange and can lead to larger and more rapid responses to redox cycling. CP systems are maturing as platforms for electrically tunable drug delivery. CPs with defined micro- or nanostructures offer the ability to increase the amount of drug that can be delivered whilst enabling systems to be finely tuned to control the extent and rate of drug release. In this review, fabrication approaches to achieve CPs with micro- or nanostructure are outlined followed by a detailed review and discussion of recent advances in the application of the materials for drug delivery.

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“…However, when drugs are given in conventional dosage forms, there can be wide fluctuations in blood and tissue drug concentrations [2]. Controlled release systems can provide longer drug release, better utilization, continuous supply, fewer side effects, and lower doses [3]. For drugs that absorb in the stomach or upper GI tract, gastroretentive drug delivery systems are preferred.…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Gastric Floating Tablets of Riboflavin Using Box-Behnken Design

SVN,

PAPPULA,

NAIK

et al. 2023

Int J App Pharm

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Objective: To develop and evaluate gastric floating tablets of riboflavin that was thermally fused using an experimental design method. Methods: Gastric floating tablets were developed using the Box-Behnken design. The effect of sintering on various tablet properties is assessed. The prepared floating tablets were tested for characteristics like usual tablet quality control tests with special emphasis on buoyancy studies and in vitro drug release studies. Results: The drug-excipient incompatibility studies indicated no interactions between riboflavin and carnauba wax. Sintering the powder at 1200, °C partially decreased its crystallinity and improved drug release for up to 16 h. The tablets demonstrated good flow properties, acceptable hardness, low friability, and uniformity in thickness and diameter. Statistical models successfully optimized the formulation to achieve desired characteristics and practical compressibility. The optimal amounts of the variables, according to Design Expert® 12 software, were 59.19 mg of carnauba wax, 14.63% w/w of sodium bicarbonate, a sintering temperature of 74.68 °C, and a sintering exposure time of 1.99 h. Conclusion: In vitro dissolution studies were conducted on the optimized formulation to verify the model's predictions. The experimental results closely matched the predictions. The optimized formulations showed a floating lag time of 104 seconds and a floating duration of 12.3 h. The obtained T90 was found to be 11.3 h which followed zero order kinetics with a non-Fickian diffusion mechanism.

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Lipids in Oral Controlled Release Drug Delivery

Cited by 8 publications

References 128 publications

Dissolution of Lipid-Based Matrices in Simulated Gastrointestinal Solutions to Evaluate Their Potential for the Encapsulation of Bioactive Ingredients for Foods

Dissolution of Lipid-Based Matrices in Simulated Gastrointestinal Solutions to Evaluate Their Potential for the Encapsulation of Bioactive Ingredients for Foods

Conducting polymers with defined micro- or nanostructures for drug delivery

Development and Evaluation of Gastric Floating Tablets of Riboflavin Using Box-Behnken Design

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