Dissolution of Lipid-Based Matrices in Simulated Gastrointestinal Solutions to Evaluate Their Potential for the Encapsulation of Bioactive Ingredients for Foods

Abstract

The goal of the study was to compare the dissolution of chocolate to other lipid-based matrices suitable for the microencapsulation of bioactive ingredients in simulated gastrointestinal solutions. Particles having approximately 750 μm or 2.5 mm were prepared from the following lipid-based matrices: cocoa butter, fractionated palm kernel oil (FPKO), chocolate, beeswax, carnauba wax, and paraffin. They were added to solutions designed to simulate gastric secretions (GS) or duodenum secretions (DS) at 37°C. Paraffin, carnauba wax, and bees wax did not dissolve in either the GS or DS media. Cocoa butter, FPKO, and chocolate dissolved in the DS medium. Cocoa butter, and to a lesser extent chocolate, also dissolved in the GS medium. With chocolate, dissolution was twice as fast as that with small particles (750 μm) as compared to the larger (2.5 mm) ones. With 750 μm particle sizes, 90% dissolution of chocolate beads was attained after only 60 minutes in the DS medium, while it took 120 minutes for 70% of FPKO beads to dissolve in the same conditions. The data are discussed from the perspective of controlled release in the gastrointestinal tract of encapsulated ingredients (minerals, oils, probiotic bacteria, enzymes, vitamins, and peptides) used in the development of functional foods.

Developments in Taste-Masking Techniques for Traditional Chinese Medicines

“…As a result, in the medium of pH 6.8, the dissolution percentage of quercetin was essentially reduced. This should be due to the hydrophobic nature of the wax [ 76 ]. Correspondingly, the bitterness value of quercetin was also significantly reduced; that is, the lower amount of quercetin released from the microencapsulated powers made the tongue unable to fully perceive the bitterness of the drug.…”

Double emulsion‐encapsulated guggul exhibits improved in vivo hypocholesterolaemic action in rats

“…Oil‐in‐water‐in‐oil (O/W/O) double emulsions have proved to be an option, to mask its flavour as well as to improve its bioavailability (Lv et al ., ). Studies have also shown that when lipid matrix is used for encapsulating sterols, their cholesterol reducing properties are optimised, and they are best transported and absorbed in the gut (Raymond & Champagne, ).…”