Lipid peroxide induced DNA damage: protection by turmeric (Curcuma longa)

Shalini, V.; Srinivas, Leela

doi:10.1007/bf00230145

Cited by 87 publications

(31 citation statements)

References 29 publications

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“…As a pure compound also, it has been found to possess antitumor, anti-cancer and anti-inflammatory activities. Several studies have clearly indicated that curcumin possesses a variety of pharmacological effects such as in wound-healing, 1) anti-oxidant [2][3][4] and anti-inflammatory activities. 5) Certain recent studies indicated that curcumin may exert its anti-inflammatory properties by: a) suppressing the activation of NF-kappaB through inhibition of IKK activity, 6) b) significantly inhibiting the LPS induced proinflammatory cytokines IL-1beta and IL-8 7) and c) inhibiting iNOS production and by scavenging NO radicals.…”

mentioning

confidence: 99%

Curcumin Attenuates Allergen-Induced Airway Hyperresponsiveness in Sensitized Guinea Pigs

Ram

Das

Ghosh

2003

Biological & Pharmaceutical Bulletin

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Curcumin (diferuloylmethane), a natural product from the rhizomes of Curcuma longa is a yellow colored polyphenolic phytochemical which has been in use for a long time for the treatment of swelling, twisting and wounds. The Indian system of medicine uses curcumin, present in its raw form in the plant extract, as a wound healer and inhibitor of swelling. As a pure compound also, it has been found to possess antitumor, anti-cancer and anti-inflammatory activities. Several studies have clearly indicated that curcumin possesses a variety of pharmacological effects such as in wound-healing, 1) anti-oxidant 2-4) and anti-inflammatory activities. 5) Certain recent studies indicated that curcumin may exert its anti-inflammatory properties by: a) suppressing the activation of NF-kappaB through inhibition of IKK activity, 6) b) significantly inhibiting the LPS induced proinflammatory cytokines IL-1beta and IL-8 7) and c) inhibiting iNOS production and by scavenging NO radicals. 8) There is some evidence that curcumin has anti-spasmodic effect on smooth muscle of dogs' intestine in-vivo and vas-defrens of guinea pig in-vitro. 9)Based on these inflammatory and anti-spasmodic properties of curcumin, we hypothesized that it could have anti-asthmatic activity as well because asthma is a chronic airway inflammatory disorder.Asthma pathogenesis involves airway inflammation coupled with airway hyperresponsiveness (AHR) to a variety of physical and pharmacological stimuli. The incidence of asthma is on the rise globally and is reaching epidemic proportions.10) The already existing remedies for asthma are known to possess detrimental side effects on prolonged use. Therefore, there is a need to explore for new anti-asthmatic agents, preferably a plant-based drug that has negligible side effects.For our study, we selected a guinea pig model because of its marked airway reactivity and a good similarity to the airways of asthmatic human subjects. 11) To test the effect of curcumin, we sensitized the animals with ovalbumin (OVA) to develop the characteristic features of asthma: antigen induced airway constriction and airway hyperreactivity to histamine. We report here for the first time that curcumin inhibits allergen induced airway constriction and airway hyperreactivity to histamine in guinea pigs. MATERIALS AND METHODSAnimals Male guinea pigs of Dunkin-Hartley strain (National Institute of Nutrition, Hyderabad, India), 8-10 weeks old, weighing 300-350 g were used and acclimatized at least one week under laboratory conditions before conducting the experiment. Animals were allowed free access to food and water throughout the experiment. Experimental protocols were approved by the institutional ethical committee. Six groups of animals (nϭ6) were used for the study.Sensitization Animals were sensitized with 3 intra-peritoneal (i.p.) injections of 20 mg OVA (Sigma Chemical, Grade V, St. Louis, MO, U.S.A.) adsorbed on 10 mg alum, Al 2 (OH) 3 in 0.5 ml 0.9% saline on alternate days. After 3 weeks of last i.p. injection, the animals were che...

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Curcumin Attenuates Allergen-Induced Airway Hyperresponsiveness in Sensitized Guinea Pigs

Ram

Das

Ghosh

2003

Biological & Pharmaceutical Bulletin

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“…The well-established 4-nitroquinoline-l-oxide (4NQ0)-induced oral carcinogenesis model was used because oral lesions induced by 4NQ0 are more comparable to human lesions than those induced by other agents. We used aqueous extracts of turmeric instead of its lipophilic principle, curcumin, because the aqueous extract has been reported to have potent antioxidant activity [9,18]. Moreover, turmeric is consumed as a whole spice in a variety of food preparations in India.…”

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Inhibition of 4-Nitroquinoline-1-Oxide-Induced Oral Carcinogenesis by Plant Products.

Manoharan

Ramachandran

et al. 1996

J. Clin. Biochem. Nutr.

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SummaryThe modifying effects of naturally occurring plant products such as neem leaf and turmeric extracts on 4-nitroquinoline-l-oxide (4NQO)-induced oral carcinoma were investigated in male Wistar strain rats. All the animals painted with 4NQ0 on their cheek mucosa for 20 weeks developed oral neoplasms identified histologically as squamous cell carcinoma. The oral tumor tissue showed a decrease in lipid peroxidation with concomitant changes in antioxidant activity. In groups of animals painted with 4NQ0 and simultaneous oral administration of neem leaf and turmeric extract, respectively, no tumors were observed; and the lipid peroxidation and antioxidant levels showed a pattern similar to that of untreated controls. Thus, the anticarcinogenic effect of neem leaf and turmeric extract appears to be related to their antioxidant function.We envisage that measurement of lipid peroxidation and antioxidant status with histological changes could be used to biomonitor tumor progression and evaluate the therapeutic response.

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“…1), has been known to exert inhibitory actions on lipid peroxidation and DNA damage induced by reactive oxygen species (9)(10)(11)(12)(13). In this study, the treatment with curcumin at concentrations ranging from 300 nM to 3 pM significantly prevented thymocytes from cell death or injury caused by H202 induced oxidative stress (Fig.…”

Section: Discussionmentioning

confidence: 56%

New Curcuminoids Isolated from Zingiber cassumunar Protect Cells Suffering from Oxidative Stress: A Flow-Cytometric Study Using Rat Thymocytes and H2O2

Nagano

Oyama

Kajita

et al. 1997

Japanese Journal of Pharmacology

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Lipid peroxide induced DNA damage: protection by turmeric (Curcuma longa)

Cited by 87 publications

References 29 publications

Curcumin Attenuates Allergen-Induced Airway Hyperresponsiveness in Sensitized Guinea Pigs

Curcumin Attenuates Allergen-Induced Airway Hyperresponsiveness in Sensitized Guinea Pigs

Inhibition of 4-Nitroquinoline-1-Oxide-Induced Oral Carcinogenesis by Plant Products.

New Curcuminoids Isolated from Zingiber cassumunar Protect Cells Suffering from Oxidative Stress: A Flow-Cytometric Study Using Rat Thymocytes and H2O2

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