New Curcuminoids Isolated from Zingiber cassumunar Protect Cells Suffering from Oxidative Stress: A Flow-Cytometric Study Using Rat Thymocytes and H2O2

Nagano, Tadayoshi; Oyama, Yasuo; Kajita, Noriko; Chikahisa, Lumi; Nakata, Mami; Okazaki, Eisuke; Masuda, Toshiya

doi:10.1254/jjp.75.363

Cited by 42 publications

(25 citation statements)

References 21 publications

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“…Recent studies have reported that curcumin has antioxidant, antiinflammatory and anticancer potentials with low toxicity [19][20][21][22]. Curcumin has been reported to rapidly induce ROS which causes caspase 3-dependent and -independent apoptosis [23] through the release of cytochrome C and apoptosis inducing factor from the mitochondria [3,24].…”

Section: Introductionmentioning

confidence: 99%

Involvement of ROS in Curcumin-induced Autophagic Cell Death

Lee

Kim

Suh

et al. 2011

Korean J Physiol Pharmacol

130

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Section: Introductionmentioning

confidence: 99%

Involvement of ROS in Curcumin-induced Autophagic Cell Death

Lee

Kim

Suh

et al. 2011

Korean J Physiol Pharmacol

130

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“…It is interesting that in China and India, curcumin has been used for thousands of years as a folk medicine to treat diverse diseases, long before the recent extensive studies revealed various biological activities of curcumin. It has been reported that curcumin has anti-inflammatory and antioxidant activities as well as a potent anticancer effect on numerous cancer cell types [12][13][14][15][16]. Moreover, in phase I and phase II clinical trials, it was proved that oral administration of curcumin (up to 12 g/day) was safe to human and conferred chemopreventive benefits on patients with high-risk and precancerous legions [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Curcumin Induces Downregulation of E2F4 Expression and Apoptotic Cell Death in HCT116 Human Colon Cancer Cells; Involvement of Reactive Oxygen Species

Kim

Lee

2010

Korean J Physiol Pharmacol

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E2F transcription factors and their target genes have been known to play an important role in cell growth control. W e found that curcumin, a polyphenolic phytochemical isolated from the plant Curcuma longa, markedly suppressed E2F4 expression in HCT116 colon cancer cells. Hydrogen peroxide was also found to decrease E2F4 protein level, indicating the involvement of reactive oxygen species (ROS) in curucmin-induced downregulation of E2F4 expression. Involvement of ROS in E2F4 downregulation in response to curcumin was confirmed by the result that pretreatment of cells with N-acetylcystein (NAC) before exposure of curcumin almost completely blocked the reduction of E2F4 expression at the protein as well as mRNA level. Anti-proliferative effect of curcumin was also suppressed by NAC which is consistent to previous reports showing curcumin-superoxide production and induction of poly (ADP-ribose) polymerase (PARP) cleavage as well as apoptosis. Expression of several genes, cyclin A, p21, and p27, which has been shown to be regulated in E2F4-dependent manner and involved in the cell cycle progression was also affected by curcumin. Moreover, decreased (cyclin A) and increased (p21 and p27) expression of these E2F4 downstream genes by curcumin was restored by pretreatment of cells with NAC and E2F4 overexpression which is induced by doxycycline. In addition, E2F4 overexpression was observed to partially ameliorate curcumin-induced growth inhibition by cell viability assay. Taken together, we found curcumin-induced ROS down-regulation of E2F4 expression and modulation of E2F4 target genes which finally lead to the apoptotic cell death in HCT116 colon cancer cells, suggesting that E2F4 appears to be a novel determinant of curcumin-induced cytotoxicity.

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“…Mistletonone exhibited scavenging capability both on hydroxyl radicals and superoxide anion radicals as compared with standard (−)-epigallocatechin gallate (Yao et al, 2007). Cassumunin A, B, C and cassumunarin A, B, C isolated from Zingiber cassumunar are also potent antioxidants showing stronger or equal antioxidant activity as that of curcumin (Nagano et al, 1997;Masuda et al, 1995). Diarylheptanoids isolated from Z. officinale especially 5-[4-hydroxy-6-(4-hydroxyphenethyl)tetrahydro-2H-pyran-2-yl]-3-methoxybenzene-1,2-diol, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(3,4-dihydroxyphenyl) heptan-3-one and 1,5-epoxy-3-hydroxy-1-(4,5-dihydroxy-3-methoxyphenyl)-7-(3,4-dihydroxyphenyl) heptanes are capable of scavenging superoxide anion radicals and inhibiting the formation of lipid peroxides in liver microsomes (Tao et al, 2008).…”

Section: Anti-oxidant Activitymentioning

confidence: 95%

Diarylheptanoids as nutraceutical: A review

Ganapathy

Preethi

Moses

et al. 2019

Biocatalysis and Agricultural Biotechnology

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Phenolic compounds are naturally occurring compounds present ubiquitously in plants. They have potential health benefits and substantiate evidence for their nutraceutical applications. Diarylheptanoids are part of the broad class of plant phenolics with structurally divergent compounds. They have been used in traditional medicines and homemade remedies to treat various ailments, as organoleptic additives in foods, and also for aesthetic purposes. With their potential therapeutic and organoleptic characteristics, diarylhepatanoids can be rightly termed as nutraceuticals. This review summarizes the wide range of pharmacological activities of diarylhepatanoids and nutraceutical formulations, with relevance to human health.

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New Curcuminoids Isolated from Zingiber cassumunar Protect Cells Suffering from Oxidative Stress: A Flow-Cytometric Study Using Rat Thymocytes and H2O2

Cited by 42 publications

References 21 publications

Involvement of ROS in Curcumin-induced Autophagic Cell Death

Involvement of ROS in Curcumin-induced Autophagic Cell Death

Curcumin Induces Downregulation of E2F4 Expression and Apoptotic Cell Death in HCT116 Human Colon Cancer Cells; Involvement of Reactive Oxygen Species

Diarylheptanoids as nutraceutical: A review

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