Lipid peroxidation products as a mediator of toxicity and adaptive response – The regulatory role of selenoprotein and vitamin E

Saito, Yoshiro

doi:10.1016/j.abb.2021.108840

Cited by 17 publications

(9 citation statements)

References 80 publications

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“…Selenium is an essential micronutrient for selenoproteins, including GPX, which contributes to the activation of these enzymes. 32,33 Vitamin C, as another nonenzymatic antioxidant, inhibits pigment production by preventing the formation of nitric oxide, which is a melanocyte-activating molecule; it also inhibits melanin synthesis. 34 On the other hand, vitamin E plays a preventive role against…”

Section: Nonenzymatic Antioxidants Including Selenium (Se) Alpha-toco...mentioning

confidence: 99%

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Evaluation of systemic oxidative stress in patients with melasma

Rahimi

Mirnezami

Yazdabadi

et al. 2023

J of Cosmetic Dermatology

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BackgroundThe significance of oxidative stress has been assessed and proven in the etiopathogenesis of many cutaneous disorders, but there are few studies that evaluated the role of only some factors involved in oxidative stress in patients with melasma.ObjectiveThis study aimed to examine the role of oxidative stress in melasma and assess the relationship between systemic oxidative stress and the severity and extension of this disease.MethodsIn this study, the serum levels of superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT), malondialdehyde (MDA), protein carbonyl (PC), selenium (Se), vitamin E (vit E), and vitamin C (vit C) of fifty patients with melasma were compared with those of fifty controls.ResultsThe serum level of MDA was significantly higher in the melasma group (3.08 vs. 2.35 U/mL; p < 0.05), and it was positively correlated with the severity (r = 0.4; p < 0.001) and extension (r = 0.3; p < 0.05) of the disease. Furthermore, the serum level of vit C was significantly lower in melasma patients (2.16 vs. 2.57 μg/mL; p < 0.001).ConclusionSystemic oxidative stress has a key role in the etiopathogenesis of melasma. Serum concentrations of MDA and vitamin C are indicators of this impairment.

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Section: Nonenzymatic Antioxidants Including Selenium (Se) Alpha-toco...mentioning

confidence: 99%

“…No trigger factor 16 ( LPO. 33,35 It can inhibit tyrosine activity as an active enzyme in melanin synthesis. Moreover, it can decrease pigment.…”

Section: Nonenzymatic Antioxidants Including Selenium (Se) Alpha-toco...mentioning

confidence: 99%

Evaluation of systemic oxidative stress in patients with melasma

Rahimi

Mirnezami

Yazdabadi

et al. 2023

J of Cosmetic Dermatology

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“…There are two types of intracellular lipid peroxidation, namely, non-enzymatic and enzymatic lipid peroxidation. Non-enzymatic lipid peroxidation, also known as lipid autoxidation, is mainly a free radical-mediated chain reaction in which hydroxyl radicals generated by the Fenton reaction oxidize polyunsaturated fatty acids to lipid hydroperoxides ( 46 ). In contrast, enzymatic lipid peroxidation is mainly a process of direct oxidation of free polyunsaturated fatty acids to various types of lipid hydroperoxides catalyzed by lipoxygenase (LOX) ( 47 , 48 ).…”

Section: Ferroptosismentioning

confidence: 99%

Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer

Zhang

Liu

2022

Front. Immunol.

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Ovarian cancer (OC) is one of the most common malignancies that causes death in women and is a heterogeneous disease with complex molecular and genetic changes. Because of the relatively high recurrence rate of OC, it is crucial to understand the associated mechanisms of drug resistance and to discover potential target for rational targeted therapy. Cell death is a genetically determined process. Active and orderly cell death is prevalent during the development of living organisms and plays a critical role in regulating life homeostasis. Ferroptosis, a novel type of cell death discovered in recent years, is distinct from apoptosis and necrosis and is mainly caused by the imbalance between the production and degradation of intracellular lipid reactive oxygen species triggered by increased iron content. Necroptosis is a regulated non-cysteine protease–dependent programmed cell necrosis, morphologically exhibiting the same features as necrosis and occurring via a unique mechanism of programmed cell death different from the apoptotic signaling pathway. Pyroptosis is a form of programmed cell death that is characterized by the formation of membrane pores and subsequent cell lysis as well as release of pro-inflammatory cell contents mediated by the abscisin family. Studies have shown that ferroptosis, necroptosis, and pyroptosis are involved in the development and progression of a variety of diseases, including tumors. In this review, we summarized the recent advances in ferroptosis, necroptosis, and pyroptosis in the occurrence, development, and therapeutic potential of OC.

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“…It is well known that when vitamin E reduces lipid peroxides, it is converted into a prooxidant that has to be reduced by another antioxidant such as vitamin C, leading to the formation of ascorbate radical. The ascorbate radical is subsequently reduced by glutathione, present in selenium-dependent GPx ( Figure 1 ) [ 163 , 164 ]. This indirect interaction between vitamin E and selenium is likely to be part of the rationale behind clinical trials that are carried out with a combination of more than two antioxidant micronutrients.…”

Section: Nutritional Factors Interfering With the Effects Of Vitamin ...mentioning

confidence: 99%

Vitamin E and Metabolic Health: Relevance of Interactions with Other Micronutrients

et al. 2022

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A hundred years have passed since vitamin E was identified as an essential micronutrient for mammals. Since then, many biological functions of vitamin E have been unraveled in both cell and animal models, including antioxidant and anti-inflammatory properties, as well as regulatory activities on cell signaling and gene expression. However, the bioavailability and physiological functions of vitamin E have been considerably shown to depend on lifestyle, genetic factors, and individual health conditions. Another important facet that has been considered less so far is the endogenous interaction with other nutrients. Accumulating evidence indicates that the interaction between vitamin E and other nutrients, especially those that are enriched by supplementation in humans, may explain at least some of the discrepancies observed in clinical trials. Meanwhile, increasing evidence suggests that the different forms of vitamin E metabolites and derivates also exhibit physiological activities, which are more potent and mediated via different pathways compared to the respective vitamin E precursors. In this review, possible molecular mechanisms between vitamin E and other nutritional factors are discussed and their potential impact on physiological and pathophysiological processes is evaluated using published co-supplementation studies.

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Lipid peroxidation products as a mediator of toxicity and adaptive response – The regulatory role of selenoprotein and vitamin E

Cited by 17 publications

References 80 publications

Evaluation of systemic oxidative stress in patients with melasma

Evaluation of systemic oxidative stress in patients with melasma

Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer

Vitamin E and Metabolic Health: Relevance of Interactions with Other Micronutrients

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