Evaluation of systemic oxidative stress in patients with melasma

Abstract

BackgroundThe significance of oxidative stress has been assessed and proven in the etiopathogenesis of many cutaneous disorders, but there are few studies that evaluated the role of only some factors involved in oxidative stress in patients with melasma.ObjectiveThis study aimed to examine the role of oxidative stress in melasma and assess the relationship between systemic oxidative stress and the severity and extension of this disease.MethodsIn this study, the serum levels of superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT), malondialdehyde (MDA), protein carbonyl (PC), selenium (Se), vitamin E (vit E), and vitamin C (vit C) of fifty patients with melasma were compared with those of fifty controls.ResultsThe serum level of MDA was significantly higher in the melasma group (3.08 vs. 2.35 U/mL; p < 0.05), and it was positively correlated with the severity (r = 0.4; p < 0.001) and extension (r = 0.3; p < 0.05) of the disease. Furthermore, the serum level of vit C was significantly lower in melasma patients (2.16 vs. 2.57 μg/mL; p < 0.001).ConclusionSystemic oxidative stress has a key role in the etiopathogenesis of melasma. Serum concentrations of MDA and vitamin C are indicators of this impairment.

Regenerative Cosmetics: Skin Tissue Engineering for Anti-Aging, Repair, and Hair Restoration

“…Being the most exposed area of the body, environmental-derived ROS activity affects skin health and appearance. Oxidative stress, an imbalance between free radicals and endogenous antioxidants, plays a central role in aging [29] and plays a major role in the etiopathogenesis or aggravation of atopic dermatitis [30], acne [31], rosacea [32], melasma [33], alopecia areata [34], and rare skin disorders [35]. Thus, it comes as no surprise that the dermocosmetics industry has paid great attention to combat its effects.…”

Bioactive Compounds for Combating Oxidative Stress in Dermatology

“…➢ Photoaging = premature aging of the skin manifested as wrinkles, laxity, spots and devitalization [10][11][12]; ➢ Atopic dermatitis = a chronic inflammatory condition manifested as dryness, itching and discomfort [12][13][14]; ➢ Psoriasis = a chronic autoimmune disease manifested by thick, squamous plaques, on large areas and causing major discomfort [15,16]; ➢ Acne = a condition characterized by the appearance of inflammatory or comedonian lesions on a hyperseborrhea background and damage to the pilo-sebaceous apparatus [17,18]; ➢ Rosacea = a chronic inflammatory condition characterized by redness, tenderness and fragility of the vascular walls in the face [19,20]; ➢ Melasma = the most difficult and extensive form of hyperpigmentation in the face [21];…”

The Impact of Antioxidants on Vitiligo and Melasma: A Scoping Review and Meta-Analysis

“…More recently, increased oxidative stress has also been shown in melasma. Serum levels of malondialdehyde (MDA), an end product of lipid peroxidation, are increased in melasma patients and correlate with disease severity and disease extent [10]. Vitamin C was decreased in melasma.…”