Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer

Abstract

Ovarian cancer (OC) is one of the most common malignancies that causes death in women and is a heterogeneous disease with complex molecular and genetic changes. Because of the relatively high recurrence rate of OC, it is crucial to understand the associated mechanisms of drug resistance and to discover potential target for rational targeted therapy. Cell death is a genetically determined process. Active and orderly cell death is prevalent during the development of living organisms and plays a critical role in regulating life homeostasis. Ferroptosis, a novel type of cell death discovered in recent years, is distinct from apoptosis and necrosis and is mainly caused by the imbalance between the production and degradation of intracellular lipid reactive oxygen species triggered by increased iron content. Necroptosis is a regulated non-cysteine protease–dependent programmed cell necrosis, morphologically exhibiting the same features as necrosis and occurring via a unique mechanism of programmed cell death different from the apoptotic signaling pathway. Pyroptosis is a form of programmed cell death that is characterized by the formation of membrane pores and subsequent cell lysis as well as release of pro-inflammatory cell contents mediated by the abscisin family. Studies have shown that ferroptosis, necroptosis, and pyroptosis are involved in the development and progression of a variety of diseases, including tumors. In this review, we summarized the recent advances in ferroptosis, necroptosis, and pyroptosis in the occurrence, development, and therapeutic potential of OC.

Identification of iron metabolism-related predictive markers of endometriosis and endometriosis-relevant ovarian cancer

“…Furthermore, iron metabolism has become a topic of interest in cancer research and demonstrates potential for novel treatment options via associated inducers and inhibitors. [ 75 ]…”

A bibliometric analysis of ferroptosis, necroptosis, pyroptosis, and cuproptosis in cancer from 2012 to 2022

“…This leads to lipidated proteins accumulation and the following loss of iron-sulfur cluster proteins, causing proteotoxic stress and eventually cell death [11]. Recently, more and more evidence have indicated that ferroptosis, necroptosis, and pyroptosis act an essential role in cancer development and the association between cuproptosis and cancer occurrence has also been sporadically reported [22][23][24][25]. CD8 + T cells modulate tumor ferroptosis during cancer immunotherapy [26].…”

Development of a necroptosis-related gene signature and the immune landscape in ovarian cancer

“…Previous studies showed that DR6 is involved in cancer cell-induced endothelial necroptosis, leading to extravasation and metastasis [ 15 ]. Lately, mounting evidence has shown that necroptosis is highly involved in various cellular processes of OC, such as chemoresistance and immune response [ 16 ]. Dey et al demonstrated that BMI1 could participate in the PINK1-PARK2-dependent mitochondrial pathway and induce a novel necroptosis-mediated cell death pattern in OC [ 17 ].…”