Lipid peroxidation and oxidative stress in rat erythrocytes induced by chlorpyrifos and the protective effect of zinc

Mansour, Sameeh A.; Mossa, Abdel‐Tawab H.

doi:10.1016/j.pestbp.2008.09.004

Cited by 196 publications

(152 citation statements)

References 42 publications

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“…as compared to control. Supporting the present findings, malathion also provoked alteration in antioxidant enzymes such as SOD, GPx following sub chronic exposure in animals (Akhgari et al, 2003;Abdollahi et al, 2004) may be due to hepato and neurotoxicity induced by several organophosphorus induced Reactive Oxygen Species (Mansour and Mossa, 2010; and associated with lipid peroxidation and phospholipids degradation (Mansour and Mossa, 2009), it has been previously reported that during liver damage there was an observed decrease in antioxidant defenses in the liver (Seven et al, 2004;Heikal et al (2012). In other hand in groups treated by malathion plus vitamine c or malathion plus green tea there were a significant decrease in activities of SOD, GSH and GPx in rat liver if compared with malathion treated group may be due to vitamin c is proposed to reduce oxidative stress from H2O2 potentially by reducing the free radical species generated from H2O2 and reduces oxidative DNA damage (Noroozi et al, 1998), more over green tea extract enhances the expression of intracellular endogenous antioxidants such as SOD and GPX by maintaining their activities higher compared to the malathion group and other antioxidants enzymes such as glutathione, glutathione reductase, glutathionereductase and quinone reductase (Valerio et al, 2001) Administration of green tea to ethanol-treated rats of different ages partly normalized the activity of enzymes and the level of non-enzymatic antioxidants (Khan et al, 2007).…”

Section: Discussionsupporting

confidence: 83%

“…Furthermore, Organophosphorus insecticides exert their biological effects through electrophilic attack on the cellular constituents of hepatic and brain tissues (Samanta and Chainy, 1995) with simultaneous generation of reactive oxygen species (Sharma et al, 2005). Reactive Oxygen Species have been implicated in hepato and neurotoxicity induced by several organophosphorus (Bagchi et al, 1995;Mansour and Mossa, 2010; and is associated with lipid peroxidation and phospholipids degradation (Mansour and Mossa, 2009). Oxidative stress occurs when the generation of reactive oxygen Species in the body exceeds the ability of the body to neutralize and eliminate them.…”

Section: Introductionmentioning

confidence: 99%

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Protective Role of Vitamin C and Green Tea Extract on Malathion-Induced Hepatotoxicity and Nephrotoxicity in Rats

Elzoghby¹,

Hamoda²,

Aboubakr³

et al. 2014

American Journal of Pharmacology and Toxicology

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The present study was designed to determine the modulating effect of green tea and vitamin C against adverse effects of malathion. Animals were divided into four groups 5 rats /group). Group one was used as a control. Group two given malathion (50 mg/kg/day; 1/50 of the LD50 for four weeks). Group three and Group four were given malathion (50 mg/kg/day; 1/50 of the LD50 for four weeks) plus vitamin C (200 mg/kg/day) and plus green tea (36 mg/kg/day) respectively. At the end of the fourth week, the malathion-treated group had significantly lower Red Blood Cell count (RBCs), Hemoglobin concentration (Hb), Packed Cell Volume (PCV%) and leucocytes (WBCs) than the control group. Compared to the control group, the malathion-treated group had significantly higher serum Alkaline Phosphatase (ALP), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Lactate Dehydrogenase (LDH), urea, creatinine and uric acid levels than the control group. The malathion treated rats also had significantly lower serum total protein, albumin and globulin levels than the control group, but the malathion plus vitamin C and malathion plus green tea groups did not differ from the control group in terms of these parameters. Moreover, concomitant vitamin C and green tea treatment significantly normalized, at least partially, all of the other hematological and biochemical parameters that were altered by malathion. Liver tissue homogenate in malathion treated group had lower Glutathione (GSH), Glutathione Peroxidase (GSH-PX) and Superoxide Dismutase (SOD) levels accompanied with higher level of Malondialdehyde (MDA) than the control group. Histopathological studies revealed that the malathion-treated, malathion plus vitamin C and malathion plus green tea treated groups exhibited histopathological changes in liver and kidney tissues, although some pathological features were only observed in the malathion-treated group. Thus, vitamin C and green tea can reduce malathion hepatotoxicity and nephrptoxicity.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Protective Role of Vitamin C and Green Tea Extract on Malathion-Induced Hepatotoxicity and Nephrotoxicity in Rats

Elzoghby¹,

Hamoda²,

Aboubakr³

et al. 2014

American Journal of Pharmacology and Toxicology

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“…The reduction in fructose content in seminal fluid collected from LCT intoxicated rats were drawn attention towards the secretory ability of seminal vesicles and the nutritive potential for the semen. Previous studies [42][43][44] reported that ROS were involved in the toxicity of various pesticides. ROS inhibits steroidogenesis by disrupting cholesterol transport to mitochondria.…”

Section: Discussionmentioning

confidence: 99%

Lambda Cyhalothrin Elicited Dose Response Toxicity on Haematological, Hepatic, Gonadal and Lipid Metabolic Biomarkers in Rat and Possible Modulatory Role of Taurine

Ghosh¹,

Das²,

Paramanik³

et al. 2016

Toxicol Forensic Med Open J

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Extensive application of pesticides is usually accompanied with serious problems of pollution and health hazards. Lambda-cyhalothrin (LCT), a type II synthetic pyrethroid, is widely used in agriculture, home pest control and protection of foodstuff. This study designed to evaluate the dose dependent haematological, hepatic and gonadal toxicity of LCT at different dose levels in Wistar rat. Investigations were also done to find out the toxic effect of lambda cyhalothrin on lipid metabolism in female rat and its amelioration by taurine. Rats were exposed to different doses of lambda cyhalothrin over a period of 14 consecutive days. Exposure to LCT produced ataxia, agitation, rolling and also tremors which were considered as the signs of toxicity. Significant decrease in erythrocyte count, haemoglobin percentage, seminal fructose concentration, hepatic and testicular reduced glutathione (GSH) content was observed. Increase in leukocyte count, serum aspartic and alanine transaminase, hepatic and testicular malondialdehyde (MDA), testicular and ovarian cholesterol after LCT treatment were seen in male rats at the dose level of 10.83 mg/kg body wt. (1/7 th LD 50 ). Elevated ovarian cholesterol and MDA and reduced 3β hydroxy steroid dehydrogenase (HSD) and GSH level were also observed in lambda cyhalothrin exposed female rat at the dose level of 6.29 mg/kg body wt.(1/9 th LD 50 ). LCT caused increase in serum triglyceride, cholesterol, low density lipoproteins (LDL), very low density lipoproteins (VLDL) and bilirubin and decrease in serum high density lipoproteins (HDL) in female rat. Taurine pretreatment ameliorated LCT induced altered lipid metabolic biomarkers in female rat.

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“…Additionally, we suggested that the increases in the level of LPO and the PC content were indicative of a decrease in the enzymatic antioxidant defense mechanism in the lung of hyperglycemic rats. GSTs are detoxifying enzymes that catalyze the conjugation of a variety of electrophilic substrates to the thiol group of GSH, producing less toxic forms (Mansour & Mossa, 2009). Thus, it can be said that the low GST activity could be directly explained by the low GSH content, as GSH is a substrate and cofactor of this enzyme.…”

Section: Discussionmentioning

confidence: 99%

Chard (Beta vulgarisvar.cicla) extract improved hyperglycemia-induced oxidative stress and surfactant-associated protein alterations in rat lungs

Öztay¹,

Saçan

Kayalar³

et al. 2015

Pharmaceutical Biology

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Context: Chard is used as an antidiabetic agent by the diabetic patients in Turkey. Objective: The effect of chard extract [Beta vulgaris L. var. cicla (Chenopodiaceae)] on the antioxidant system and the expression of surfactant-associated proteins (SP) in the lungs of hyperglycemic rats were examined. Materials and methods: Hyperglycemia was induced by a single dose of streptozotocin (60 mg/kg) provided intraperitoneally. Fourteen days after the rats were rendered hyperglycemic, the chard (2 g/kg/d), insulin (6 U/kg/d), and chard plus insulin (as mentioned above) were administered to rats for 45 d. On day 60, rats' lungs were removed. Oxidative stress parameters and SP expression were assayed. Results: The lungs of hyperglycemic rats were characterized by the induced lipid and protein oxidation, elevated myeloperoxidase and xanthine oxidase activities, decreased glutathione levels, and reduced tissue factor and antioxidant enzymes activities (catalase, superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase). Chard treatment alone and chard treatment combined with insulin were capable of achieving a regression of pulmonary oxidative stress, by inhibiting lipid and protein oxidation, and restoring the antioxidant system of hyperglycemic rats. SP-A expressions were significantly unchanged in all groups, whereas pro-SP-C and SP-D expressions were reduced in hyperglycemic rats. Pro-SP-C and SP-D levels were increased by chard and insulin administrations alone and combined in hyperglycemic rats. Discussion and conclusion: All treatments have a positive effect on the surfactant and antioxidant systems of the lungs of hyperglycemic rats. The best therapeutic effect was provided by treatment with chard extract alone in the compensation of hyperglycemic symptoms.

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Lipid peroxidation and oxidative stress in rat erythrocytes induced by chlorpyrifos and the protective effect of zinc

Cited by 196 publications

References 42 publications

Protective Role of Vitamin C and Green Tea Extract on Malathion-Induced Hepatotoxicity and Nephrotoxicity in Rats

Protective Role of Vitamin C and Green Tea Extract on Malathion-Induced Hepatotoxicity and Nephrotoxicity in Rats

Lambda Cyhalothrin Elicited Dose Response Toxicity on Haematological, Hepatic, Gonadal and Lipid Metabolic Biomarkers in Rat and Possible Modulatory Role of Taurine

Chard (Beta vulgarisvar.cicla) extract improved hyperglycemia-induced oxidative stress and surfactant-associated protein alterations in rat lungs

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