Lipid peroxidation and antioxidant status in experimental diabetes

Feillet‐Coudray, Christine; Rock, Edmond; Coudray, Charles; Grzelkowska, K.; Azaı̈s-Braesco, Véronique; Dardevet, Dominique; Mazur, Andrzej

doi:10.1016/s0009-8981(99)00046-7

Cited by 208 publications

(123 citation statements)

References 35 publications

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“…There have been discordant reports about vitamin E levels in patients with metabolic syndrome or type 2 diabetes, showing either lower vitamin Ε concentrations in participants who had a feature of the metabolic syndrome and also consumed fewer fruits and vegetables [36], or no difference among participants with the metabolic syndrome or type 2 diabetes [37,38]. Only one study to our knowledge has reported slightly higher serum γ-tocopherol levels [38] and no changes of α-tocopherol among participants with the metabolic syndrome.…”

Section: Discussionmentioning

confidence: 90%

LDL from obese patients with the metabolic syndrome show increased lipid peroxidation and activate platelets

et al. 2011

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Aims/hypothesis This study assessed oxidative stress in LDL from obese patients with the metabolic syndrome and compared it with that in LDL from type 2 diabetic patients or control volunteers. It also determined the effect on platelets of LDL from the three groups. Methods The profiles of lipids, fatty acids and fatty acid oxidation products were determined in LDL isolated from plasma of patients with the metabolic syndrome, patients with type 2 diabetes and volunteers (n=10 per group). The effects of LDL from the participant groups on the platelet arachidonic acid signalling cascade and aggregation were investigated. Results Compared with LDL from control volunteers, LDL from obese metabolic syndrome and type 2 diabetic patients had lower cholesteryl ester, higher triacylglycerol and lower ethanolamine plasmalogen levels. Proportions of linoleic acid were decreased in phosphatidylcholine and cholesteryl esters in LDL from both patient groups. Among the markers of lipid peroxidation, oxidation products of linoleic acid (hydroxy-octadecadienoic acids) and malondialdehyde were increased by 59% and twofold, respectively in LDL from metabolic syndrome and type 2 diabetic patients. LDL from metabolic syndrome and type 2 diabetic patients were equally potent in activating the platelet arachidonic acid signalling cascade through increased phosphorylation of p38 mitogen-activated protein kinase and cytosolic phospholipase A 2 , and through increased thromboxane B 2 formation. LDL from patients with the metabolic syndrome and type 2 diabetes potentiated platelet aggregation by threefold and 3.5-fold respectively, whereas control LDL had no activating effects on platelets. Conclusions/interpretation The metabolic syndrome in obese patients, without or with diabetes, is associated with increased oxidative stress in LDL, which triggers platelet activation.

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Section: Discussionmentioning

confidence: 90%

LDL from obese patients with the metabolic syndrome show increased lipid peroxidation and activate platelets

et al. 2011

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“…The present results indicated the elevation of lipid peroxidation under diabetes. Other studies also reported that the formation of lipid peroxidation products in serum and tissues under diabetes is elevated (42,43), and leads to diabetic complications including retinopathy and neuropathy (44,45). The decrease in lipid peroxidation by the BuOH fraction from the broccoli flower implies a protective role against diabetic oxidative stress induced by STZ.…”

Section: Discussionmentioning

confidence: 92%

Protective Effects of Broccoli (Brassica oleracea) against Oxidative Damage in Vitro and in Vivo

Cho¹,

Lee²,

Yoo³

et al. 2006

J Nutr Sci Vitaminol

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SummaryThe antioxidative effect and protective potential against diabetes of the broccoli flower were investigated both in vitro and in a diabetic rat model. Among fractions of MeOH, CH 2 Cl 2 , BuOH, and H 2 O, the BuOH fraction exerted the strongest inhibitory activities on 1,1-diphenyl-2-picrylhydrazyl radical, radical-induced protein oxidation, and nitric oxide generation by sodium nitroprusside. The in vitro results suggest that the BuOH fraction from the broccoli flower has a protective potential against oxidative stress. The rat model with diabetes induced by streptozotocin was employed to evaluate the protective effect of the BuOH fraction in vivo. Diabetic rats showed reduced body weight gain and heavier kidney and liver weights than normal rats, while oral administration of the BuOH fraction at an oral dose of 100 or 200 mg/kg body weight/d for 20 d attenuated the physiological changes induced by diabetes. In addition, oral administration of the BuOH fraction to diabetic rats led to significant decreases in serum glucose and glycosylated protein, while it resulted in the increase of serum albumin, implying that the BuOH fraction improves the abnormal metabolism of glucose and protein that leads to oxidative stress. Moreover, it significantly reduced thiobarbituric acid-reactive substance levels in serum, hepatic and renal mitochondria. This suggests that the BuOH fraction would alleviate the oxidative stress associated with diabetes through the inhibition of lipid peroxidation. The present study demonstrates that the BuOH fraction has an antioxidative effect in vitro and it protects against oxidative stress induced by diabetes in an in vivo model.

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“…Previous experiments also reported that there is a direct damage to the septohippocampal system on ICV injection of STZ (Blokland et al, 1993). Oxidative stress that has developed due to ICV injection of STZ (Feillet et al, 1999) known to cause damage to the myelin of neurons which known to be responsible for spatial memory deficits in animal models (Shoham et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effect of Garcinia Mangostana on Streptozotocin Induced Sporadic Type Alzheimer’s Disease in Mice

Avinash

Reddy²,

Begum

et al. 2016

IJAPSR

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ABSTRACT:Objectives: The main objective of the study is to determine the neuroprotective potential of ethonolic extract of Garcinia mangostana (EEGM) in mouse against IntracerebroventricularStreptozotocin (ICV -STZ) induced sporadic type Alzheimer"s disease. Methods: Neurotoxicity was induced by ICV injection of STZ (0.5 mg/kg/b.w) as a first dose then the second dose after the 48 hours and the animals were pre-treated with ethanolic extract of Garcinia mangostana for 28 days. To assess the behavioral parameters learning and memory, open field and Y-maze were employed. Acetylcholinesterase, antioxidant enzymes (superoxide dismutase, glutathione peroxidise, reduced glutathione and catalase) were estimated in brain tissue. Results: Pre-treatment with EEGM (200 and 400 mg/kg/b.w) exhibited a dose dependent reduction of AChE levels and increased habituation memory and percentage alteration which are indicative of the enhanced cognitive function. The extract showed significant increase in the antioxidant parameter. Conclusion:The study results suggested that the neuroprotective potentiality of EEGM against ICV STZ induced neurotoxicity. The extract of EEGM proved to have a potential therapeutic action in preventing or decreasing the progression of sporadic Alzheimer"s disease due to aging and oxidative stress.

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Lipid peroxidation and antioxidant status in experimental diabetes

Cited by 208 publications

References 35 publications

LDL from obese patients with the metabolic syndrome show increased lipid peroxidation and activate platelets

LDL from obese patients with the metabolic syndrome show increased lipid peroxidation and activate platelets

Protective Effects of Broccoli (Brassica oleracea) against Oxidative Damage in Vitro and in Vivo

Neuroprotective Effect of Garcinia Mangostana on Streptozotocin Induced Sporadic Type Alzheimer’s Disease in Mice

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