Lipid Nanocarriers for Dermal Delivery of Lutein

Sk, Jindal; Kumar, Avichal; Goyal, Kamya; Awasthi, Rajendra; Kulkarni, Giriraj T.

doi:10.1007/978-981-15-1664-1_12

Cited by 4 publications

(3 citation statements)

References 42 publications

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“…It is clear that the burn contraction was in the following order: A > C > B > D, treatment with the TTO-loaded nanolipogel attained the significantly fastest and best healing compared with other treatments ( p < 0.05); this was expected as a result of the nanoencapsulation of TTO in the lipid-type nanoformula enhancing the release of the active agents and facilitating their penetration and deposition into the skin layers, which in turn accelerated the healing process and dermal repair [ 26 , 27 , 28 , 29 , 56 ]. The partial healing effect of the unmedicated lipogel may be due to the well-documented proliferative and regenerative properties of cellulose nanofibers matrix [ 30 , 32 , 78 ].…”

Section: Resultsmentioning

confidence: 99%

“…In addition, they are suitable carriers for application to damaged and inflamed skin and they have a well-reported occlusive property based on their lipid nature, an important factor in accelerating wound healing [ 25 ]. Some previous publications have proven the efficiency of lipid-type nanocarriers for dermal delivery and repair [ 26 , 27 , 28 , 29 ]. These studies were focused on enhancing the solubility and efficacy of natural compounds with low aqueous solubility (such as rutin, diosmin, resveratrol, curcumin, and lutein) to target their delivery efficiently to the skin.…”

Section: Introductionmentioning

confidence: 99%

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Nanolipogel Loaded with Tea Tree Oil for the Management of Burn: GC-MS Analysis, In Vitro and In Vivo Evaluation

et al. 2022

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The GC-MS analysis of tea tree oil (TTO) revealed 38 volatile components with sesquiterpene hydrocarbons (43.56%) and alcohols (41.03%) as major detected classes. TTO efficacy is masked by its hydrophobicity; nanoencapsulation can address this drawback. The results showed that TTO-loaded solid lipid nanoparticles (SLN1), composed of glyceryl monostearate (2% w/w) and Poloxamer188 (5% w/w), was spherical in shape with a core-shell microstructure. TTO-SLN1 showed a high entrapment efficiency (96.26 ± 2.3%), small particle size (235.0 ± 20.4 nm), low polydispersity index (0.31 ± 0.01), and high negative Zeta potential (−32 mV). Moreover, it exhibited a faster active agent release (almost complete within 4 h) compared to other formulated TTO-SLNs as well as the plain oil. TTO-SLN1 was then incorporated into cellulose nanofibers gel, isolated from sugarcane bagasse, to form the ‘TTO-loaded nanolipogel’ which had a shear-thinning behavior. Second-degree thermal injuries were induced in Wistar rats, then the burned skin areas were treated daily for 7 days with the TTO-loaded nanolipogel compared to the unmedicated nanolipogel, the TTO-loaded conventional gel, and the normal saline (control). The measurement of burn contraction proved that TTO-loaded nanolipogel exhibited a significantly accelerated skin healing, this was confirmed by histopathological examination as well as quantitative assessment of inflammatory infiltrate. This study highlighted the success of the proposed nanotechnology approach in improving the efficacy of TTO used for the repair of skin damage induced by burns.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nanolipogel Loaded with Tea Tree Oil for the Management of Burn: GC-MS Analysis, In Vitro and In Vivo Evaluation

et al. 2022

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“…Due to the combined beneficial properties of nanocellulose like the ability to prolong drug release [ 14 , 15 ], stabilize emulsions [ 16 , 17 ], and enhance the regeneration of cells [ 13 , 15 , 17 ] besides its potential antimicrobial properties [ 18 ], it was used with great success in wound healing preparations [ 17 , 19 , 20 , 21 ]. On the other hand, lipid type nanocarriers have proven a great success as dermal preparations for protective as well as therapeutic purposes [ 22 , 23 , 24 , 25 , 26 , 27 ]. The study aimed to combine the beneficial effects of lipid nanocarriers and nanocellulose to prepare an optimized nanoformula for dermal repair.…”

Section: Introductionmentioning

confidence: 99%

Computational Investigation to Design Ofloxacin-Loaded Hybridized Nanocellulose/Lipid Nanogels for Accelerated Skin Repair

AbouSamra

Hoffy

El-Wakil

et al. 2022

Gels

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The pharmaceutical application of biomaterials has attained a great success. Rapid wound healing is an important goal for many researchers. Hence, this work deals with the development of nanocellulose crystals/lipid nanogels loaded with ofloxacin (OFX) to promote skin repair while inhibiting bacterial infection. Ofloxacin-loaded hybridized nanocellulose/lipid nanogels (OFX-HNCNs) were prepared and evaluated adopting a computational method based on regression analysis. The optimized nanogels (OFX-HNCN7) showed a spherical outline with an encapsulation efficiency (EE), particle size (PS) and zeta potential (ZP) values of 97.53 ± 1.56%, 200.2 ± 6.74 nm and −26.4 ± 0.50 mV, respectively, with an extended drug release profile. DSC examination of OFX-HNCN7 proved the amorphization of the encapsulated drug into the prepared OFX-HNCNs. Microbiological studies showed the prolonged inhibition of bacterial growth by OFX-HNCN7 compared to the free drug. The cytocompatibility of OFX-HNCN7 was proved by Sulforhodamine B assay. Tissue repair was evaluated using the epidermal scratch assay based on cell migration in human skin fibroblast cell line, and the results depicted that cell treated with OFX-HNCN7 showed a faster and more efficient healing compared to the control. In overall, the obtained findings emphasize the benefits of using the eco-friendly bioactive nanocellulose, hybridized with lipid, to prepare a nanocarrier for skin repair.

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Lovastatin Loaded Solid lipid nanoparticles for Transdermal delivery: In vitro Characterization

Gupta

Sharma

Gaur³

et al. 2022

RJPT

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Lovastatin-loaded solid lipid nanoparticles were prepared by using glyceryl monostearate as lipid by solvent emulsification diffusion technique. The prepared SLNs were evaluated for particle size, shape, polydispersity index,zeta potential, percent drug loading, and in vitro release profile.The results reveal that the optimized SLNs are spherical, with a smooth surface and having particle size 298±1.1 nm, the PDI and zeta potential of optimized formulation was 0.42±0.09 and -19.1±0.81 MeV, respectively, the percent drug loading was 49.81±0.87. The optimized formulation follows Higuchi’s kinetics for drug release.

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Lipid Nanocarriers for Dermal Delivery of Lutein

Cited by 4 publications

References 42 publications

Nanolipogel Loaded with Tea Tree Oil for the Management of Burn: GC-MS Analysis, In Vitro and In Vivo Evaluation

Nanolipogel Loaded with Tea Tree Oil for the Management of Burn: GC-MS Analysis, In Vitro and In Vivo Evaluation

Computational Investigation to Design Ofloxacin-Loaded Hybridized Nanocellulose/Lipid Nanogels for Accelerated Skin Repair

Lovastatin Loaded Solid lipid nanoparticles for Transdermal delivery: In vitro Characterization

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