Lovastatin Loaded Solid lipid nanoparticles for Transdermal delivery: In vitro Characterization

Gupta, Dinesh; Sharma, Satish Kumar; Gaur, Praveen Kumar; Singh, Alok Pratap

doi:10.52711/0974-360x.2022.00181

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…Since a bulk lipid or lipid mixture must always be shrunk down to the nano dimension, all three generations of lipid nanoparticles can essentially be made using the same techniques. There are several ways to make lipid nanoparticles, including the membrane contractor method (Bagul, Pisal et al 2018), the ultrasonic-solvent emulsification method (Adel, Khaled et al 2022), the solvent injection method (Yadav, Shah et al 2022), the solvent emulsification-diffusion method (Gupta, Sharma et al 2022), the solvent injection method using multiple emulsions (Jacob, Nair et al 2022), the microemulsion technique (Khairnar, Pagare et al 2022), and the high-pressure homogenization method (Khairnar, Pagare et al 2022).…”

Section: Smart Lipidsmentioning

confidence: 99%

Lipid-Based Nanosystems as Advanced Approach for Drug Delivery

Gad,

fekri,

mohamed

2023

Records of Pharmaceutical and Biomedical Sciences

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In the past twenty years, the market for drug delivery has finally seen the entry of nanotechnology. The development and application of chemical, physical, and biological systems with structural characteristics ranging from single atoms or molecules to submicron dimensions, as well as the integration of the resulting nanostructures into larger systems, are the domains of nanotechnology. The field of medical nanotechnology has demonstrated a growing tendency towards cost reduction and enhanced efficacy in the use of current medications, diagnostic tools, implants, prosthetics, patient monitors, and personal health care. To maximize activity and minimize side effects, the search for intelligent drug delivery systems was the main objective. This review discusses nano-structured materials as an important category of advanced nanotechnology-based carriers. Polymeric-based, non-polymeric-based, and lipid-based nanosystems can all be classified as nanostructured materials. This review provides an overview of the most recent variations of this classification in particular lipid-based nanosystems, including those that may be considered promising in the fight against cancer disease.

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Section: Smart Lipidsmentioning

confidence: 99%

Lipid-Based Nanosystems as Advanced Approach for Drug Delivery

Gad,

fekri,

mohamed

2023

Records of Pharmaceutical and Biomedical Sciences

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“…The pH value of the prepared microemulgel was measured using a digital pH meter (EQ-610, Equiptronics, Sai Lab, India) that was calibrated before measurements 39 .…”

Section: Determination Of Phmentioning

confidence: 99%

• Development of nanoemulsion loaded acyclovir nanogel for transdermal delivery and its evaluation

Telange,

Pawar,

Amkar

et al. 2023

Pharm Sci Asia

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Acyclovir (ACV) is an antiviral drug that is primarily used to treat herpes zoster virus (HSV) infections. HSV infections in deeper regions of the skin, i.e., nerve junctions, and appeared as a red spot on the upper part of the skin. The objective of the research is to formulate and evaluate an emulgel loaded with ACV microemulsion (ME) in order to treat herpes infections and to get effects from the deeper region of the skin. MEs were prepared by high-pressure homogenization, and then microemulgels were prepared by the dispersion method. Microemulgel characteristics are being determined, and an in vitro diffusion study was performed. In this study, we have developed and evaluated an ACV-loaded microemulgel using Carbopol 940 as the gelling agent. The characteristics and stability of ACV-loaded microemulgels were studied, and in vitro drug diffusion of the optimized microemulgel, i.e., MEG3, was found to be 95±2.4% with a sustained effect for 8 hours. Observation shows that the optimized microemulgel has a smaller globule size, and hence it may move to the deeper regions of the skin. Stability studies did not show any significant change; hence, it is apparent that the drug substance or product will remain within the acceptance criteria during shelf life. It was concluded that the ACV-loaded microemulgel was prepared successfully for transdermal delivery.

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Improved Topical Drug Delivery: Role of Permeation Enhancers and Advanced Approaches

et al. 2022

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The delivery of drugs via transdermal routes is an attractive approach due to ease of administration, bypassing of the first-pass metabolism, and the large skin surface area. However, a major drawback is an inability to surmount the skin’s stratum corneum (SC) layer. Therefore, techniques reversibly modifying the stratum corneum have been a classical approach. Surmounting the significant barrier properties of the skin in a well-organised, momentary, and harmless approach is still challenging. Chemical permeation enhancers (CPEs) with higher activity are associated with certain side effects restricting their advancement in transdermal drug delivery. Furthermore, complexity in the interaction of CPEs with the skin has led to difficulty in elucidating the mechanism of action. Nevertheless, CPEs-aided transdermal drug delivery will accomplish its full potential due to advancements in analytical techniques, synthetic chemistry, and combinatorial studies. This review focused on techniques such as drug–vehicle interaction, vesicles and their analogues, and novel CPEs such as lipid synthesis inhibitors (LSIs), cell-penetrating peptides (CPPs), and ionic liquids (ILs). In addition, different types of microneedles, including 3D-printed microneedles, have been focused on in this review.

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Lovastatin Loaded Solid lipid nanoparticles for Transdermal delivery: In vitro Characterization

Cited by 6 publications

References 23 publications

Lipid-Based Nanosystems as Advanced Approach for Drug Delivery

Lipid-Based Nanosystems as Advanced Approach for Drug Delivery

• Development of nanoemulsion loaded acyclovir nanogel for transdermal delivery and its evaluation

Improved Topical Drug Delivery: Role of Permeation Enhancers and Advanced Approaches

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