Lipid lowering effect of synthetic phenolic compound in a high- fat diet (HFD) induced hyperlipidemic mice

Abstract

Hyperlipidemia is the major risk factor of arteriosclerosis, coronary heart diseases and death. Phenolic compounds have been shown to offer the protection against cardiovascular complications. In the present study, we studied the effect of semisynthetic phenolic compounds on the hyperlipidemic mice fed with high fat diet (cholesterol, cholic acid and peanut oil). Phenolic compounds were mixed with HFD and the dose of the test compounds were 1 0mg/kg for 6 weeks. After 6 weeks, the average body weight of lab diet, HFD, standard and test compounds were evaluated. Average body weight of test compound 1, test compound 2 and test compound 3 showed insignificant results (P>1) as compared to the standard drug (Atorvastatin in this study). The liver weight of mice increased (P>1) in all treatment groups relative to standard drug fed group. The plasma lipids such as triglyceride and LDL-cholesterol were found to be increased (P>1) in Test compound 1, test compound 2 , test compound 3 and HFD fed mice when compared to that of standard drug ( Atorvastatin) fed mice. But high-density lipoprotein (HDL) cholesterol increased in standard when compared to that of lab diet fed mice, HFD and test compounds. In conclusion, the supplementation of semi synthetic phenolic compounds may have a weak potential of hypolipidemic effect on mice fed high-fat diet.

High-efficient extraction of principal medicinal components from fresh Phellodendron bark (cortex phellodendri)

“…The three-good extraction yield of berberine were achieved by hydrochloric acid/methanol-ultrasonic, hydrochloric acid/distilled water-ultrasonic and hydrochloric acid/ethanol-ultrasonic. The three-good extraction yield of palmatine were achieved hydrochloric acid/ethanol-ultrasonic, hydrochloric acid/methanol-ultrasonic and hydrochloric acid/methanol-Soxhlet (Nawaz et al, 2017).…”

High fat diet induced obesity model using four strains of mice: Kunming, C57BL/6, BALB/c and ICR

“…In previous report, significant body weight gain compared with control was considered as criteria of successfully constructed obese mice model [ 2 , 20 ]. While HFD induced body weight increase, significantly higher body weight than control is not always consistence with obesity and its relevant symptoms [ 28 ]. It was found that HFD induced obesity in C57BL/6J and BALB/c mice, which are obesity prone mice sub-strain of C57BL/6 and BALB/c respectively, and increased their body weight.…”

Effect of aqueous extract of black pepper and ajwa seed on liver enzymes in alloxan-induced diabetic Wister albino rats

“…Diabetes mellitus has become a global problem in recent decades: it is a leading cause of blindness, end stage renal disease and non-traumatic amputation. Its prevalence increased day by day worldwide without any plateau ( Spanou and Tziomalos, 2013 , Nawaz et al, 2017a , Nawaz et al, 2017b ). So, there is need of healthy natural products to cure this disease ( Abbas et al, 2017 , Gohar et al, 2017 ).…”