Lipid-Based Nanotechnology: Liposome

Abstract

Over the past several decades, liposomes have been extensively developed and used for various clinical applications such as in pharmaceutical, cosmetic, and dietetic fields, due to its versatility, biocompatibility, and biodegradability, as well as the ability to enhance the therapeutic index of free drugs. However, some challenges remain unsolved, including liposome premature leakage, manufacturing irreproducibility, and limited translation success. This article reviews various aspects of liposomes, including its advantages, major compositions, and common preparation techniques, and discusses present U.S. FDA-approved, clinical, and preclinical liposomal nanotherapeutics for treating and preventing a variety of human diseases. In addition, we summarize the significance of and challenges in liposome-enabled nanotherapeutic development and hope it provides the fundamental knowledge and concepts about liposomes and their applications and contributions in contemporary pharmaceutical advancement.

Current Advances of Nanomaterial-Based Oral Drug Delivery for Colorectal Cancer Treatment

“…This "stealth" effect is produced by inducing protein binding and regulation as well as reducing degradation using metabolic enzymes. This is due to the fact that certain polymers block the entry or recognition of blood proteins, protein hydrolases, and antibodies during blood circulation [32]. Such an assembly structure will enable it to have a higher drug loading capacity when encapsulating the drug, and a certain thickness of the shell will enable it to pass through the gastrointestinal tract without leaking the drug and gradually release the drug when it reaches the target site in the intestine, so as to achieve the effect of controlled release.…”

Cellular uptake and viability switch in the properties of lipid-coated carbon quantum dots for potential bioimaging and therapeutics

“…lipids can effectively be used to encapsulate both hydrophilic within the inner aqueous compartment or hydrophobic in the lipid acyl chain region. Indeed, lipids serve as a protective barrier for the enclosed molecular cargo, ensuring its stability 13,14 .…”

“…lipids can effectively be used to encapsulate both hydrophilic within the inner aqueous compartment or hydrophobic in the lipid acyl chain region. Indeed, lipids serve as a protective barrier for the enclosed molecular cargo, ensuring its stability 13,14 . Indeed, lipid molecules can effortlessly diffuse through the membrane, where van der Waals interactions among hydrocarbon chains propel the internalization of the lipid membrane 15 .…”