Current Advances of Nanomaterial-Based Oral Drug Delivery for Colorectal Cancer Treatment

Wang, Nuoya; Chen, Liqing; Huang, Wei; Gao, Zhonggao; Jin, Mingji

doi:10.3390/nano14070557

Cited by 4 publications

(2 citation statements)

References 110 publications

(124 reference statements)

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“…Additionally, membrane-camouflaged nanoparticles may possess inherent biological functionalities derived from the membrane source, such as targeting ligands, cell adhesion molecules, or immunomodulatory proteins, which can further enhance their therapeutic efficacy or diagnostic capabilities [ 349 , 350 ]. Spherical vesicles with unique capabilities, with curcumin (CUR) that was encapsulated within stealth liposomes made of 1,2-distearol-sn-glycero-phosphoethanolamin-N-(poly[ethylene glycol], upon exposure to LED light (2.5 J/cm²), demonstrated significant photocytotoxicity against squamous cell carcinoma (SCC-25) and melanoma skin cancer cells (MUG-Mel2), resulting in apoptosis rates of 40% and 30%, respectively [ 351 , 352 ].…”

Section: Nanopharmaceuticals In Photo-based Treatmentsmentioning

confidence: 99%

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Petrovic,

Bita,

Barbinta-Patrascu

2024

IJMS

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This study provides a brief discussion of the major nanopharmaceuticals formulations as well as the impact of nanotechnology on the future of pharmaceuticals. Effective and eco-friendly strategies of biofabrication are also highlighted. Modern approaches to designing pharmaceutical nanoformulations (e.g., 3D printing, Phyto-Nanotechnology, Biomimetics/Bioinspiration, etc.) are outlined. This paper discusses the need to use natural resources for the “green” design of new nanoformulations with therapeutic efficiency. Nanopharmaceuticals research is still in its early stages, and the preparation of nanomaterials must be carefully considered. Therefore, safety and long-term effects of pharmaceutical nanoformulations must not be overlooked. The testing of nanopharmaceuticals represents an essential point in their further applications. Vegetal scaffolds obtained by decellularizing plant leaves represent a valuable, bioinspired model for nanopharmaceutical testing that avoids using animals. Nanoformulations are critical in various fields, especially in pharmacy, medicine, agriculture, and material science, due to their unique properties and advantages over conventional formulations that allows improved solubility, bioavailability, targeted drug delivery, controlled release, and reduced toxicity. Nanopharmaceuticals have transitioned from experimental stages to being a vital component of clinical practice, significantly improving outcomes in medical fields for cancer treatment, infectious diseases, neurological disorders, personalized medicine, and advanced diagnostics. Here are the key points highlighting their importance. The significant challenges, opportunities, and future directions are mentioned in the final section.

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Section: Nanopharmaceuticals In Photo-based Treatmentsmentioning

confidence: 99%

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Petrovic,

Bita,

Barbinta-Patrascu

2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Factors that can significantly affect this include varying pH in the GI tract, the presence of degradable enzymes in the small and large intestines, and variations between patients [ 24 ]. To overcome these challenges, drugs must be protected in the form of prodrugs, micelles, liposomes, and nanoparticles before delivery to the specific region [ 25 ]. This review discusses several clinically approved prodrugs for delivering 5-FU to treat CRC.…”

Section: Introductionmentioning

confidence: 99%

Review of Prodrug and Nanodelivery Strategies to Improve the Treatment of Colorectal Cancer with Fluoropyrimidine Drugs

Sarkar,

Kiren,

Gmeiner

2024

Pharmaceutics

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Fluoropyrimidine (FP) drugs are central components of combination chemotherapy regimens for the treatment of colorectal cancer (CRC). FP-based chemotherapy has improved survival outcomes over the last several decades with much of the therapeutic benefit derived from the optimization of dose and delivery. To provide further advances in therapeutic efficacy, next-generation prodrugs and nanodelivery systems for FPs are being developed. This review focuses on recent innovative nanodelivery approaches for FP drugs that display therapeutic promise. We summarize established, clinically useful FP prodrug strategies, including capecitabine, which exploit tumor-specific enzyme expression for optimal anticancer activity. We then describe the use of FP DNA-based polymers (e.g., CF10) for the delivery of activated FP nucleotides as a nanodelivery approach with proven activity in pre-clinical models and with clinical potential. Multiple nanodelivery systems for FP delivery show promise in CRC pre-clinical models and we review advances in albumin-mediated FP delivery, the development of mesoporous silica nanoparticles, emulsion-based nanoparticles, metal nanoparticles, hydrogel-based delivery, and liposomes and lipid nanoparticles that display particular promise for therapeutic development. Nanodelivery of FPs is anticipated to impact CRC treatment in the coming years and to improve survival for cancer patients.

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Transformative Impact of Nanocarrier‐Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons

Kim,

Shin,

Zhao

et al. 2024

Small Science

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Advancing therapeutic progress is centered on developing drug delivery systems (DDS) that control therapeutic molecule release, ensuring precise targeting and optimal concentrations. Targeted DDS enhances treatment efficacy and minimizes off‐target effects, but struggles with drug degradation. Over the last three decades, nanopharmaceuticals have evolved from laboratory concepts into clinical products, highlighting the profound impact of nanotechnology in medicine. Despite advancements, the effective delivery of therapeutics remains challenging because of biological barriers. Nanocarriers offer a solution with a small size, high surface‐to‐volume ratios, and customizable properties. These systems address physiological and biological challenges, such as shear stress, protein adsorption, and quick clearance. They allow targeted delivery to specific tissues, improve treatment outcomes, and reduce adverse effects. Nanocarriers exhibit controlled release, decreased degradation, and enhanced efficacy. Their size facilitates cell membrane penetration and intracellular delivery. Surface modifications increase affinity for specific cell types, allowing precise treatment delivery. This study also elucidates the potential integration of artificial intelligence with nanoscience to innovate future nanocarrier systems.

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Current Advances of Nanomaterial-Based Oral Drug Delivery for Colorectal Cancer Treatment

Cited by 4 publications

References 110 publications

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Nanoformulations in Pharmaceutical and Biomedical Applications: Green Perspectives

Review of Prodrug and Nanodelivery Strategies to Improve the Treatment of Colorectal Cancer with Fluoropyrimidine Drugs

Transformative Impact of Nanocarrier‐Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons

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