Cellular uptake and viability switch in the properties of lipid-coated carbon quantum dots for potential bioimaging and therapeutics
Sweny Jain,
Nidhi Sahu,
Dhiraj Bhatia
et al.
Abstract:Carbon quantum dots derived from mango leaves exhibited bright red fluorescence. These negatively charged particles underwent coating with the positively charged lipid molecule N-[1-(2,3-dioleyloxy) propyl]-N,N,N-trimethylammonium chloride (DOTMA). However, the bioconjugate displayed reduced uptake compared to the standalone mQDs in cancer cells (SUM 159A), and increased uptake in the case of epithelial (RPE-1) cells. Upon in vitro testing, the bioconjugate demonstrated a mitigating effect on the individual to… Show more
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