Linking vitamin D status, executive functioning and self‐perceived mental health in adolescents through multivariate analysis: A randomized double‐blind placebo control trial

Grung, Bjørn; Sandvik, Asle M.; Hjelle, Kay Morten; Dahl, Lisbeth; Frøyland, Livar; Nygård, Irene; Hansen, Anita L.

doi:10.1111/sjop.12353

Cited by 19 publications

(12 citation statements)

References 37 publications

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“…Moreover, our results emphasize the TSH role in strengthening the relationship between glycemia and workers’ capacity to develop their work while they are sick. The present findings also contribute to the literature by considering the negative impact that high blood glucose has on individuals’ cognitive functions and job performance [ 18 , 38 ] and by showing that high levels of TSH moderate these effects. Thus, the current results indicated that high TSH may increase the detrimental effects of high glycemia on workers’ capacity to perform their tasks.…”

Section: Discussionsupporting

confidence: 74%

Presenteeism and Productivity: The Role of Biomarkers and Hormones

Ferreira

Pérez-Nebra

Costa

et al. 2021

IJERPH

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Purpose. This study aimed to assess whether self-reported productivity despite presenteeism may be affected by biomarkers and hormones and how these physiological indicators can interact with each other to explain the presenteeism dimensions. Methods. This pilot study included 180 healthy participants with a mean age of 41.22 years (SD = 13.58), 76.11% of whom were female. The dependent variable included a self-reported measure of productivity loss due to presenteeism: the Stanford Presenteeism Scale 6. This study also includes physiological indicators such as biomarkers (C-reactive protein (CRP) and blood glucose) and hormones (cortisol and TSH thyroid hormone). Results. Multiple linear regression analyses revealed that CRP moderated the relationship between cortisol levels and productivity despite presenteeism. Moreover, the increase of TSH moderated the relationship between cortisol, glycemia, and employees’ capacity to complete work tasks while sick. Conclusions. The results highlight TSH’s moderating role in decreasing employees’ capacity to fulfill tasks when these individuals have high levels of glycemia and cortisol in their blood. These findings have practical and theoretical implications based on a fuller understanding of how biomarkers and hormones explain productivity despite presenteeism.

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Section: Discussionsupporting

confidence: 74%

Presenteeism and Productivity: The Role of Biomarkers and Hormones

Ferreira

Pérez-Nebra

Costa

et al. 2021

IJERPH

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“…Two of the studies included in the qualitative review were excluded from quantitative analysis because they did not report sufficient data and the corresponding authors could not be contacted. The 25 trials included in the meta‐analysis were conducted in Australia (4 trials: Dean et al, 2011; Lansdowne & Provost, 1998; Mousa, Naderpoor, de Courten, & de Courten, 2018; Sanders et al, 2011), Iran (8 trials: Alavi et al, 2018; Ghaderi et al, 2017; Jamilian et al, 2018; Khoraminya et al, 2013; Mozaffari‐Khosravi, Nabizade, Yassini‐Ardakani, Hadinedoushan, & Barzegar, 2013; Raygan, Ostadmohammadi, Bahmani, & Asemi, 2018; Sepehrmanesh et al, 2016; Vaziri et al, 2016), Norway (4 trials: Grung et al, 2017; Jorde & Kubiak, 2018; Jorde et al, 2008; Kjaergaard et al, 2012), United States (4 trials: Arvold et al, 2009; Bertone‐Johnson et al, 2012; Mason et al, 2016; Yalamanchili & Gallagher, 2012), Denmark (1 trial: Frandsen, Pareek, Hansen, & Nielsen, 2014), China (1 trial: Wang et al, 2016), Netherlands (1 trial: Rolf et al, 2017), Sweden (1 trial: von Berens et al, 2018), and New Zealand (1 trial: Choukri, Conner, Haszard, Harper, & Houghton, 2018). Sample size ranged from 34 to 726.…”

Section: Resultsmentioning

confidence: 99%

Section: Baseline Characteristics Of Included Studiesmentioning

confidence: 99%

The effect of vitamin D supplement on negative emotions: A systematic review and meta‐analysis

Cheng

Huang

2020

Depress Anxiety

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Background The several meta‐analyses of the effect of vitamin D on depression have produced inconsistent results and studies dealing with anxiety were not incorporated. There has been no comprehensive analysis of how results are affected by the nature of the sample or the dosage and duration of supplementation. The study is aimed to investigate whether vitamin D supplementation reduces negative emotions and to analyze the possible influence of sample and regimen. Method We conducted a systematic review and meta‐analysis of randomized controlled trials comparing the effect of vitamin D and placebo on negative emotion. Databases were searched for relevant articles published before February 2019. Results The analysis covered 25 trials with a total of 7,534 participants and revealed an effect of vitamin D on negative emotion (Hedges' g = −0.4990, 95% CI [−0.8453, −0.1528], p = .0047, I2 = 97.7%). Subgroup analysis showed that vitamin D had an effect on patients with major depressive disorder and on subjects with serum 25(OH)D levels ≤50 nmol/L. The pooled data from trials of vitamin D supplementation lasting ≥8 weeks and dosage ≤4,000 IU/day indicated that vitamin D had an effect. Conclusions Our results support the hypothesis that vitamin D supplementation can reduce negative emotions. Patients with major depressive disorder and individuals with vitamin D deficiency are most likely to benefit from supplementation. But to interpret the results with high heterogeneity should still be cautious.

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“…Before vitamin D supplementation, the general mean status of 25-hydroxyvitamin D was 42 nmol/L, and after supplementation, the average was 62 nmol/L). Also, the group that received vitamin D supplementation improved their performance in the most demanding subtasks of ToH [19].…”

Section: Main Clinical Studies Systematic Reviews and Meta-analysis -Last 3 Yearsmentioning

confidence: 94%

Major Meta-Analysis, Randomized Clinical Studies, and International Consensus on Serum Levels and Importance of Supplementing Vitamin D: State of the art

Filho¹,

Ramirez²,

Filho³

2021

MedNEXT

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Introduction: Hypovitaminosis D is highly prevalent and constitutes a public health problem worldwide. It can affect more than 90% of individuals, depending on the population studied. Objective: To make a broad analysis of the world literature to compose the State of the Art on serum vitamin D levels and its adequate supplementation, to prevent and mitigate various diseases, based on randomized clinical studies, analysis, and latest international conferences and consensus. Methods: The present study followed a literary review of randomized clinical studies, meta-analysis, and the latest international consensus. Cochrane instrument was adopted to assess the quality of the included studies between 2015 and 2020. Major considerations and conclusion: Laboratory evaluation should be performed by measuring 25(OH)D, and the main groups of individuals at risk for vitamin D deficiency are the elderly, patients with osteoporosis, history of falls and fractures, obese, pregnant women, and infants. For patients with osteoporosis and increased risk of fractures, recommended that concentrations of 25(OH)D remain above 30 ng/mL for full benefits on the prevention of secondary hyperparathyroidism, decreased risk of falls. Special considerations must have taken to pregnant women and infants, in patients with chronic renal failure, obese patients, and those undergoing bariatric surgery. Several clinical studies and current meta-analysis have shown significant results with vitamin D supplementation in cardiovascular complications, diabetes, cancer, autoimmune diseases, cognitive function, among others, with doses above 30 ng/mL, reaching up to 70 ng/mL, and maintaining serum dosage at 50 ng/mL.

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Linking vitamin D status, executive functioning and self‐perceived mental health in adolescents through multivariate analysis: A randomized double‐blind placebo control trial

Cited by 19 publications

References 37 publications

Presenteeism and Productivity: The Role of Biomarkers and Hormones

Presenteeism and Productivity: The Role of Biomarkers and Hormones

The effect of vitamin D supplement on negative emotions: A systematic review and meta‐analysis

Major Meta-Analysis, Randomized Clinical Studies, and International Consensus on Serum Levels and Importance of Supplementing Vitamin D: State of the art

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