Linfohistiocitosis hemofagocítica asociada a infecciones virales: reto diagnóstico y dilema terapéutico

Mostaza-Fernández, J.L.; Laso, J. Guerra; Ule, D. Carriedo; Morales, Joan Manzanares

doi:10.1016/j.rce.2014.03.009

Cited by 19 publications

(11 citation statements)

References 40 publications

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“…Although viruses are the most common triggering factors for HLH, other triggering factors are bacteria, fungi, and parasites. Examples of viral triggering factors are herpesvirus (Epstein-Barr virus [EBV], Cytomegalovirus [CMV], VHH8, HSV), HIV, HTLV, hepatitis virus (A, B and C), measles, mumps, rubella, adenovirus, dengue, hantavirus, parvovirus B19, enterovirus and influenza [3]. Macrophage activation syndrome is a form of secondary HLH that occurs in patients with autoimmune diseases [4].…”

Section: Introductionmentioning

confidence: 99%

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Hemophagocytic Lymphohistiocytosis and Inflammatory Bowel Disease: Case Report and Systematic Review

et al. 2020

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Aim: To report a case of a female patient with hemophagocytic lymphohistiocytosis (HLH) and to systematically review the available cases of the association between HLH and inflammatory bowel disease (IBD). Methods: In accordance to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, retrieval of studies was based on Medical Subject Headings and Health Sciences Descriptors, which were combined using Boolean operators. Searches were run on the electronic databases Scopus, Web of Science, MED-LINE (PubMed), Biblioteca Regional de Medicina, Latin American and Caribbean Health Sciences Literature, Cochrane Library for Systematic Reviews and Opengrey.eu. Languages were restricted to English, Spanish and Portuguese. There was no date of publication restrictions. The reference lists of the studies retrieved were searched manually. Results: The search strategy retrieved 223 references. In the final analysis, 28 references were included, with the report of 35 cases. The most common clinical finding was fever, 57% of patients had a cytomegalovirus infection and 30 patients were on thiopurines previously to HLH diagnosis. Most patients were treated with steroids and antiviral therapy. All-cause mortality was 22%. Conclusion: These findings suggest that there might be a connection of HLH to IBD, opportunistic viral infections and the use of thiopurines. Due to the severity of such disease, the clinical suspicion is paramount to early diagnosis and therapy.

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Section: Introductionmentioning

confidence: 99%

“…The most frequent are systemic juvenile idiopathic arthritis, followed by systemic lupus erythematosus, Kawasaki disease and juvenile dermatomyositis [5]. In addition to autoimmune triggers, other factors like tumors especially lymphomas, transplants, drugs, pregnancy, vaccines, surgery and hemodialysis can lead to secondary HLH [3].…”

Section: Introductionmentioning

confidence: 99%

Hemophagocytic Lymphohistiocytosis and Inflammatory Bowel Disease: Case Report and Systematic Review

et al. 2020

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“…Además, el equipo de salud que recibe a estos pacientes no utiliza habitualmente el Equipo de protección personal (EPP) adecuado, debido a que el virus del Dengue no se transmite por vía respiratoria. Sumado a ello, algunos virus como el COVID-19 y el Dengue pueden desencadenar una linfohistiocitosis hemofagocítica secundaria, llevando a los pacientes a presentar shock hipovolémico, vasoplejía y colapso cardiopulmonar debido a la hiperinflamación e hiperactivación del sistema inmunológico [13][14] . Un claro ejemplo de lo antes mencionado es lo sucedido en febrero en Tailandia donde se confirmaron 35 casos de Covid-19; entre los que reportó un caso de un paciente que presentó la coinfección entre estos dos virus, con un desenlace fatal 15 .…”

Section: Coinfección De Dengue Y Covid-19unclassified

Coinfección entre dengue y COVID-19: Necesidad de abordaje en zonas endémicas

Saavedra-Velasco

Chiara-Chilet

Pichardo-Rodriguez

et al. 2020

Rev Fac Cien Med Univ Nac Cordoba

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El impacto que ha originado la enfermedad por coronavirus 2019 (COVID-19) en diferentes partes del mundo, alcanza en la actualidad 597, 072 personas contagiadas y 27,364 fallecidas según los últimos reportes. En ese contexto, en nuestro país, una zona de relevancia epidemiológica es la amazonia peruana, debido a la distribución de enfermedades endémicas como las enfermedades metaxénicas (Dengue, Malaria entre otras), en donde el problema se incrementa debido a que la infección por COVID-19 puede llevar a falsos positivos en las pruebas de cribado para Dengue. Conllevando de esa forma a un retraso en el diagnóstico de la infección por COVID-19 y una mayor diseminación del virus, debido a que en la mayor parte de los casos de Dengue no se presentan signos de alarma y el tratamiento es ambulatorio. Este artículo busca emitir una opinión sobre la necesidad del abordaje de casos de coinfección entre Dengue y Covid-19 en zonas endémicas.

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“…and fungi (typically Histoplasma spp.) [ 2 , 5 - 7 ]. The malignancies most frequently associated with HPS are lymphomas and related autoimmune disorders such as systemic lupus erythematosus (SLE) and adult Still’s disease (ASD).…”

Section: Introductionmentioning

confidence: 99%

Hemophagocytic syndrome in patients infected with the human immunodeficiency virus: A study of 15 consecutive patients

Suárez-Hormiga¹,

Jaén-Sánchez²,

Verdugo-Espinosa³

et al. 2020

Rev Esp Quimioter

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Objectives. Hemophagocytic syndrome (HPS) is characterized by various clinical and biological data derived from cytokine hyperproduction and cell proliferation. The objectives of this study were to evaluate the epidemiological, etiological, clinical and evolutionary characteristics of patients diagnosed with hemophagocytic syndrome and HIV infection, as well as their comparison with data from the literature. Methods. A retrospective descriptive observational study was performed, including all adult patients with a diagnosis of HPS and HIV infection treated in the Infectious Diseases and Tropical Medicine Unit of the Hospital Universitario Insular, Las Palmas, Gran Canaria from June 1, 1998 to December 31, 2018. Results. An analysis of this series of case reports of 15 patients showed a higher percentage of males than females, with a mean age of 42 years. With respect to the diagnostic criteria for HPS, presence of fever, cytopenias and hyperferritinemia were a constant in all patients. Clinical neurological manifestations were frequent and clinical respiratory signs and symptoms absent. HPS was confirmed in some patients who were not severely immune-depressed and had undetectable viral loads. Furthermore, 40% of cases were not receiving ART. The most frequent triggering causes of HPS were viral, especially HHV-8. In addition, two new HPS triggers were identified: Blastocystis dermatitidis and Mycobacterium chelonae. Conclusion. Administration of treatment in HPS is arbitrary. This, together with the high mortality rate and the fact that it is underdiagnosed, indicates the importance of conducting future studies.

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Linfohistiocitosis hemofagocítica asociada a infecciones virales: reto diagnóstico y dilema terapéutico

Cited by 19 publications

References 40 publications

Hemophagocytic Lymphohistiocytosis and Inflammatory Bowel Disease: Case Report and Systematic Review

Hemophagocytic Lymphohistiocytosis and Inflammatory Bowel Disease: Case Report and Systematic Review

Coinfección entre dengue y COVID-19: Necesidad de abordaje en zonas endémicas

Hemophagocytic syndrome in patients infected with the human immunodeficiency virus: A study of 15 consecutive patients

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