Linearity of eprinomectin pharmacokinetics in lactating dairy sheep following pour-on administration: Excretion in milk and exposure of suckling lambs

Efficacy of eprinomectin pour-on treatment in sheep naturally infected withDictyocaulus filariaandCystocaulus ocreatus

“…Eprinomectin is an antiparasitic drug which is preferable both for gastrointestinal and lungworm infections since it leaves neglectible residue levels in cattle (Shoop et al, 1996;Alvinerie et al, 1999b), sheep (Hodošček et al, 2008) and goat milk (Alvinerie et al, 1999a;Dupuy et al, 2001). In previous studies performed (Shoop et al, 1996;Pitt et al, 1997;Williams et al, 1997;Cramer et al, 2000;Hö glund et al, 2003), eprinomectin has been reported to be very effective against D. viviparus, which is a cattle lungworm.…”

Trace analysis of endectocides in milk by high performance liquid chromatography with fluorescence detection

“…blood plasma, milk products, fat, muscle tissue, muscle and skin in natural proportions (fish) and eggs, analysed within the research [24,33] and monitoring [30,34] programmes in Slovenia.…”

“…The depletion of EPR in milk after pour-on administration at two dose levels was studied in Istrian Pramenka sheep, a Slovenian autochthonous dairy breed and was part of the pharmacokinetic study evaluating EPR concentrations in blood plasma and milk of ewes and blood plasma of suckling lambs [23,24]. Twelve healthy lactating ewes, each with a single suckling lamb, were used and were randomly divided into two groups of six sheep with six suckling lambs.…”

“…Maximum mean EPR concentrations for six sheep were 1.3 and 5.3 g kg −1 , and were detected on day 2 for both the 0.5 and 1.0 mg kg −1 doses, respectively. EPR was found in all samples investigated (with concentrations ≥ 0.04 g kg −1 ), taken even over 30 days post-treatment [23,24].…”

“…In Slovenia, residues of endectocides have been followed during state monitoring of veterinary drug residues in food of animal origin since 1994, when analysis of IVM as the first such substance was introduced [19,20]. Since then, endectocide analysis has developed according to progressive addition of specific substances for research and monitoring purposes [21][22][23][24].…”