Ligustrazine Phosphate Ethosomes for Treatment of Alzheimer’s Disease, In Vitro and in Animal Model Studies

Shi, Jun; Wang, Yiming; Luo, Guangsheng

doi:10.1208/s12249-012-9767-6

Cited by 57 publications

(35 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The application was first put forward by Touitou in 1996(Touitou, 1996 and was specially tailored to efficiently deliver various molecules into deep skin layers and across the skin (Ainbinder et al, 2010). Ethosomes has been studied for delivery of various drugs ranging from low molecular weight drugs such as acyclovir , minoxidil (Jun-Bo et al, 2007), tacrolimus (Li et al, 2012), ligustrazine phosphate (Shi et al, 2012), econazole nitrate (Verma & Pathak, 2012), ibuprofen (Shumilov et al, 2010) to polypeptides and gene medicines (Godin & Touitou, 2003).…”

Section: Introductionmentioning

confidence: 99%

Penetration profile and human cadaver skin distribution of finasteride from vesicular nanocarriers

et al. 2013

View full text Add to dashboard Cite

The skin accumulation of therapeutic agents affects the efficiency of topical drug delivery. In this study, in vitro distribution of finasteride of ethosomes and liposomes in human cadaver skin after percutaneous delivery were investigated. Experiments were performed using modified Franz diffusion cells. Finasteride ethosomes, liposomes or hydroethanolic solutions were used as donor medium. Drug distribution at different skin layers and depths were studied by hotplate separation and frozen horizontal slicing technique. The result showed that the accumulation of finasteride in skin ranged from 9.7-24.3 mg/cm 2 at 12 or 24 hours. The ethosomes demonstrated better enhancing ability to deliver finasteride into the dermis layer than liposomes did. The finasteride concentration in the dermis layer from ethosomes was more than sevenfold higher than from liposomes. The finasteride accumulation in ethosomes group showed a distinctive reversed distribution profile. This distinctive reversed distribution profile is meaningful for exerting a favorable pharmacological effect for finasteride. The drug distribution profile in skin layers showed no significant difference between 12 and 24 hours application (p40.05). The study demonstrated that finasteride can be accumulated at target site more effectively and maintained at higher level through the application of novel ethosomal carriers.

show abstract

Section: Introductionmentioning

confidence: 99%

Penetration profile and human cadaver skin distribution of finasteride from vesicular nanocarriers

et al. 2013

View full text Add to dashboard Cite

show abstract

“…With regard to cognition enhancing function, TMP has been shown to improve learning and memory ability in scopolamine-or D-galactose-lesioned rodents (Zhang et al, 2004;Shi et al, 2012). Although these insults provide animal models of memory deficit, there are few literatures referring to the protective potential of TMP in more physiologically relevant models of Alzheimer's disease.…”

Section: Discussionmentioning

confidence: 99%

Tetramethylpyrazine, a natural alkaloid, attenuates pro-inflammatory mediators induced by amyloid β and interferon-γ in rat brain microglia

Kim

Lee

et al. 2014

European Journal of Pharmacology

View full text Add to dashboard Cite

“…Also, ethosomes can be used to increase the bioavailability of natural products [24] . For instance, in previous studies, ethosomes were used to enhance penetration of ligustrazine [25] and alkaloids from Sophora alopecuroides [26] . Thus, this drug delivery system is likely to increase the penetration of QC through the skin.…”

Section: In Vitro Penetration and Bioavailability Of Novel Transdermamentioning

confidence: 99%

In vitro Penetration and Bioavailability of Novel Transdermal Quercetin-loaded Ethosomal Gel

Ramadon¹,

Anwar²,

Harahap³

2017

pharmaceutical-sciences

View full text Add to dashboard Cite

Quercetin has been widely used to treat many diseases because of its high antioxidant activity. However, it has low oral bioavailability and penetration through the skin. The aim of this research was to enhance penetration and bioavailability of quercetin using transdermal ethosomal gel. Three ethosomal formulae, E1 (1 %), E2 (1.5 %) and E3 (2 %) with different concentration of quercetin were prepared using thin-film hydration method. Their physical properties were characterized, and then a selected ethosomal formula was incorporated into a gel dosage form. Two gels, one ethosomal and the other non-ethosomal were prepared. In vitro penetration using Franz diffusion cells and bioavailability study in Sprague Dawley male rats were carried out. Results showed that E2 was the chosen formula to be incorporated into the gel dosage form. According to the in vitro penetration study, the diffusion flux of quercetin from the ethosomal and non-ethosomal gels were 343.35±17.69 ng/cm 2 /h and 120.68±11.92 ng/cm 2 /h, respectively (P<0.05). In the bioavailability study, ethosomal gel showed higher maximum concentration (C max ) and area under curve (AUC 0-t ) when compared to non-ethosomal gel and oral suspension. C max from the ethosomal gel, nonethosomal gel, and oral suspension were 413.49±28.64, 189.46±49.68, and 61.92±14.31 ng/ml, respectively (P<0.05). AUC 0-t from the ethosomal gel, non-ethosomal gel, and oral suspension were 4035.15±560.60, 584.87±265.46, and 431.21±239.85, respectively (P<0.05). In conclusion, ethosomal gel could increase penetration and bioavailability of quercetin compared to non-ethosomal gel.

show abstract

Ligustrazine Phosphate Ethosomes for Treatment of Alzheimer’s Disease, In Vitro and in Animal Model Studies

Cited by 57 publications

References 28 publications

Penetration profile and human cadaver skin distribution of finasteride from vesicular nanocarriers

Penetration profile and human cadaver skin distribution of finasteride from vesicular nanocarriers

Tetramethylpyrazine, a natural alkaloid, attenuates pro-inflammatory mediators induced by amyloid β and interferon-γ in rat brain microglia

In vitro Penetration and Bioavailability of Novel Transdermal Quercetin-loaded Ethosomal Gel

Contact Info

Product

Resources

About