Penetration profile and human cadaver skin distribution of finasteride from vesicular nanocarriers

Abstract

The skin accumulation of therapeutic agents affects the efficiency of topical drug delivery. In this study, in vitro distribution of finasteride of ethosomes and liposomes in human cadaver skin after percutaneous delivery were investigated. Experiments were performed using modified Franz diffusion cells. Finasteride ethosomes, liposomes or hydroethanolic solutions were used as donor medium. Drug distribution at different skin layers and depths were studied by hotplate separation and frozen horizontal slicing technique. The result showed that the accumulation of finasteride in skin ranged from 9.7-24.3 mg/cm 2 at 12 or 24 hours. The ethosomes demonstrated better enhancing ability to deliver finasteride into the dermis layer than liposomes did. The finasteride concentration in the dermis layer from ethosomes was more than sevenfold higher than from liposomes. The finasteride accumulation in ethosomes group showed a distinctive reversed distribution profile. This distinctive reversed distribution profile is meaningful for exerting a favorable pharmacological effect for finasteride. The drug distribution profile in skin layers showed no significant difference between 12 and 24 hours application (p40.05). The study demonstrated that finasteride can be accumulated at target site more effectively and maintained at higher level through the application of novel ethosomal carriers.

Effects of solvents and penetration enhancers on transdermal delivery of thymoquinone: permeability and skin deposition study

“…These data support the study reported by Rao et al. ( 2015 ) and also confirmed that ethanol can reduce the time needed for a drug to reach steady state (Rao et al., 2015 ).…”

Novel reverse electrodialysis-driven iontophoretic system for topical and transdermal delivery of poorly permeable therapeutic agents

“…The slope of the linear portion in the plot was calculated as the flux (μg/h/cm 2 ) (Ibrahim et al., 2015 ; Salah et al., 2017 ). The lag time was calculated by extrapolating the linear portion to the X-axis of the plot (Rao et al., 2015 ; Salah et al., 2017 ). Non-compartmental analysis was performed using the WinNonlin software (Version 4.0; Certara USA Inc., Princeton, NJ) to determine the in vivo pharmacokinetic parameters.…”