Tetramethylpyrazine, a natural alkaloid, attenuates pro-inflammatory mediators induced by amyloid β and interferon-γ in rat brain microglia

Kim, Mia; Kim, Sung-Ok; Lee, Moonsung; Lee, Joon‐Hyung; Jung, Woon Won; Moon, Sang-Kwan; Kim, Young-Suk; Cho, Ki-Ho; Ko, Chang‐Nam; Lee, Eunjoo H.

doi:10.1016/j.ejphar.2014.06.037

Cited by 69 publications

(34 citation statements)

References 34 publications

(43 reference statements)

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“…It can also ameliorate impairment of learning and memory in rats by antagonizing neurotoxicity of Aβ [40, 41]. TMP may be useful in ameliorating microglia-mediated inflammatory by Aβ [42], and studies also suggest it could remarkably enhance learning and memory in AD mice model [43]. TSG has exhibited neuroprotection against brain ischemic injury [44] and can improve cognitive deficits in aged rats [45] according to several studies.…”

Section: Discussionmentioning

confidence: 99%

Cognitive Improvement during Treatment for Mild Alzheimer’s Disease with a Chinese Herbal Formula: A Randomized Controlled Trial

et al. 2015

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ObjectivesTo explore the efficacy of Chinese herbal formula compared with donepezil 5mg/day in patients with mild Alzheimer’s disease (AD).MethodsPatients with mild AD meeting the criteria were randomized into Chinese herbal formula Yishen Huazhuo decoction (YHD) group and donepezil hydrochloride (DH) group during the 24-week trial. The outcomes were measured by ADAS-cog, MMSE, ADL, and NPI with linear mixed-effect models.Results144 patients were randomized. The mean scores of ADAS-cog and MMSE in both YHD group and DH group both improved at the end of the 24-week treatment period. The results also revealed that YHD was better at improving the mean scores of ADAS-cog and MMSE than DH. Linear mixed-effect models with repeated measures showed statistical significance in time × group interaction effect of ADAS-cog and also in time × group interaction effect of MMSE. The data showed YHD was superior to DH in improving the scores and long term efficacy.ConclusionsOur study suggests that Chinese herbal formula YHD is beneficial and effective for cognitive improvement in patients with mild AD and the mechanism might be through reducing amyloid-β (Aβ) plaque deposition in the hippocampus.Trial RegistrationChinese Clinical Trial Registry ChiCTR-TRC-12002846

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Section: Discussionmentioning

confidence: 99%

Cognitive Improvement during Treatment for Mild Alzheimer’s Disease with a Chinese Herbal Formula: A Randomized Controlled Trial

et al. 2015

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“…The Annexin V-FITC/PI apoptosis detection kit according to the manufacturer's instructions (Roche Diagnostics, Indianapolis, IN, USA). Briefly, ccRCC cells were seeded in 6-well plates and treated with 100 µM TMP for 48 h. Cells 1x10 6 were collected and suspended in 500 µl binding buffer, and 5 µl Annexin V-FITC and 5 µl PI were added to each sample and incubated in the dark for 15 min. The cell surface phosphatidylserine in apoptotic cells was quantitatively estimated by using Annexin V/FITC apoptosis detection kit according to manufacturer's instructions (Roche Diagnostics).…”

Section: Reverse Transcription Polymerase Chain Reaction (Rt-pcr)mentioning

confidence: 99%

“…Ligusticum chuanxiong, which has been widely used in the clinical treatment of neurovascular, cardiovascular and liver diseases in China (1)(2)(3)(4)(5)(6). In recent years, increasing number of studies have suggested that TMP possesses anticancer properties (7)(8)(9)(10)(11).…”

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confidence: 99%

Tetramethypyrazine inhibits renal cell carcinoma cells through inhibition of NKG2D signaling pathways

Luan

Liu

Xue

et al. 2016

International Journal of Oncology

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Tetramethypyrazine (TMP), one of the active compounds extracted from the traditional Chinese medicinal herb (Chuanxiong), has been verified as an anticancer compound against several types of cancer. However, understanding of the molecular mechanisms have not been fully elucidated. In the present study, the anticancer efficacy of TMP was investigated in human clear cell renal cell carcinoma (ccRCC) cells. We showed that TMP significantly inhibited ccRCC cell viability, proliferation, apoptosis, invasion and migration through the methods of MTT, flow cytometry, wound healing and transwell assays. Furthermore, reverse transcription polymerase chain reaction (RT-PCR), western blotting and immunofluorescence results demonstrated TMP upregulation of the expression of NKG2D ligands (NKG2DLs) MHC class I chain-related molecules A and B (MICA/B) and epithelial cell expression marker of E-cadherin, and downregulation of mesenchymal cell expression markers of vimentin and fibronectin. Taken together, the inhibition of TMP on ccRCC cells might be mediated via inhibition of NKG2D related signaling pathway to further suppress epithelial-mesenchymal transition (EMT) progression. The binding of NKG2D to its ligands activates NK cells, giving the rationale for studies on the utilization of TMP as a potential cancer therapeutic compound to increase NK cells-mediated cytotoxicity against high MICA/B expression in cancer cells.

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“…1 This plant is mainly distributed in the Sichuan province but also in Yunnan, Guizhou, and Guangxi provinces in China. So far, the phenolic acids, alkaloids, and phthalides [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] contained in it have been investigated. Among these compounds, tetramethylpyrazine and ferulic acid were considered to be the active constituents.…”

Section: Introductionmentioning

confidence: 99%

Phthalide derivatives from Ligusticum chuanxiong

et al. 2017

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Tetramethylpyrazine, a natural alkaloid, attenuates pro-inflammatory mediators induced by amyloid β and interferon-γ in rat brain microglia

Cited by 69 publications

References 34 publications

Cognitive Improvement during Treatment for Mild Alzheimer’s Disease with a Chinese Herbal Formula: A Randomized Controlled Trial

Cognitive Improvement during Treatment for Mild Alzheimer’s Disease with a Chinese Herbal Formula: A Randomized Controlled Trial

Tetramethypyrazine inhibits renal cell carcinoma cells through inhibition of NKG2D signaling pathways

Phthalide derivatives from Ligusticum chuanxiong

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