Periodontitis is one of the most highly prevalent chronic diseases worldwide. Periodontal disease, along with severe dental caries, causes tooth loss, which result in reduced functional capacity, selfesteem and social relationships. Hence, it affects people's quality of life .Periodontitis is associated with several risk factors among which, is tobacco smoking. (3) Throughout the years, studies has recorded delirious effect of smoking on periodontal tissues. However, there were different selected populations and /or different methodologies among these studies. In addition, the precise mechanism by which tobacco influences periodontal destruction and its related alteration still need complementary investigation (4,5,6) . It has been observed that smoking can alter salivary fluid, salivary enzymes. Yet, only a few studies has recorded the effect of tobacco smoking on salivary immunoglobulin (7,8)