Lignin-Based Nanoparticles Stabilized Pickering Emulsion for Stability Improvement and Thermal-Controlled Release of trans-Resveratrol

Abstract

In this work, we designed a novel multifunctional Pickering emulsion stabilized by lignin-based nanoparticles. We utilized the industrial waste lignin to prepare thermoresponsive lignin copolymer by grafting poly­(N-isopropylacrylamide) (PNIPAM) onto lignin via atom transfer radical polymerization (ATRP) and then formed self-assembled nanoparticles (AL-g-PNIPAM NPs). AL-g-PNIPAM NPs well stabilized trans-resveratrol (trans-RSV)-containing palm oil emulsion droplets in water. Thanks to the abundant UV chromophoric groups of lignin, the light stability of trans-RSV was significantly improved by the protecting of the AL-g-PNIPAM NPs layer. Moreover, the emulsion properties and release behavior strongly depend on the temperature and nanoparticles size: decreasing temperature induced deformation of AL-g-PNIPAM NPs at the interface, an increase in droplet size, and the accelerated release of trans-RSV. These results showed the great potential of this approach of a green functional lignin-based nanoparticles stabilized Pickering emulsion for storage and thermal-controlled release of light-unstable and poorly water-soluble drugs.

Spherical lignin particles: a review on their sustainability and applications

“…While O/W emulsions based on aliphatic or aromatic hydrocarbons have been easy to stabilize using LNPs, 38,47,[87][88][89][90] vegetable oils have been more challenging, even if using chemically modified lignin such as the graft copolymer of lignin and N-isopropylacrylamide as a source of nanoparticles. 91 Nevertheless, food, cosmetics and biomedical materials require non-toxic oils and emulsifiers. Recently, Zou et al showed that vegetable oil-water emulsions could be stabilized using LNPs coated with chitosan.…”

Green Synthesis and Characterization of Gold Nanoparticles Using Lignin Nanoparticles

“…The LNPs were prepared following The anti-solvent method [19]. Specifically, 0.1 g lignin was added to 150 mL ethanol under magnetic stirring at 300 rpm for 2 h. Then, 70 mL deionized water was poured into The lignin/ethanol mixture, and The mixed solution was stirred for 4 h until The solution became a uniform solution.…”

Centrifugal fractionation of softwood extracts improves the biorefinery workflow and yields functional emulsifiers

“…In this case, oil-in-water or water-in-oil Pickering emulsions are formed. 32,33 Besides the extraction and purification methods, the particle preparation method also greatly affects the emulsifying performance of lignin particles. 32 Moreover, stable oil-in-water emulsions can be obtained using lignincontaining food grade materials such as cocoa particles 34 and spent coffee grounds.…”