Lifetime of Neutral Carrier-Based Membranes in Aqueous Systems and Blood Serum

Design of neutral hydrogen ion carriers for solvent polymeric membrane electrodes of selected pH range

“…"Logarithm of the partition coefficient between water and octan-l-ol as determined by thin-layer chromatography (TLC). 6 A value of 11.6 has been reported in our earlier papers (21,22). More extensive investigations in the frame of this work revealed that it is originated in an impurity in the batch of TDDA used at that time.…”

“…The ionophores presented here have been designed to exhibit a high lipophilicity (see Table I). This is necessary to cope with the high lipophilic character of biological samples which will promote the extraction of low molecular weight components (21).…”

Mathematical Model of Current‐Polarized Ionophore‐Based Ion‐Selective Membranes: Large Current Chronopotentiometry

“…0.1 ng) [9]. With the dissolution of membrane components, the membrane resistance increases, the response slope of the ISE decreases, and the membrane selectivity can drop below a critical value or eventually be lost completely [3,4,7].…”

“…In general, the highly hydrophobic nature of the membrane components minimize their partition into an aqueous electrolyte while the high concentration of anionic or cationic sites in the membrane prevent the partitioning of whole bathing salts, such as KCl, into the membrane [2]. However, the relevant partition coefficients are orders of magnitude less advantageous in membrane/serum systems [7]. Consequently, with decreasing membrane dimensions, and extended use in large volumes of biological samples, like whole blood, the dissolution of membrane components can limit the sensor lifetime.…”

“…When these ion-selective membranes are brought in contact with a sample, such as whole blood, a two way equilibration process is initiated. In this process, the membrane components partition between the membrane (organic) and solution (aqueous) phases [3,4], and concurrently the solution components partition between the solution and the membrane [5,6]. In general, the highly hydrophobic nature of the membrane components minimize their partition into an aqueous electrolyte while the high concentration of anionic or cationic sites in the membrane prevent the partitioning of whole bathing salts, such as KCl, into the membrane [2].…”