Lidocaine intensifies the anti-osteogenic effect on inflammation-induced human dental pulp stem cells via mitogen-activated protein kinase inhibition

Lee, Sanghoon; Kim, Cheul-Hong; Yoon, Ji‐Young; Choi, Eun‐Ji; Kim, Mi Kyoung; Yoon, Ji-Uk; Kim, Hee Young; Kim, Eun-Jung

doi:10.1016/j.jds.2022.11.020

Cited by 3 publications

(2 citation statements)

References 43 publications

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“…By reducing pain and inflammation, lidocaine might create a more conducive environment for bone regeneration. While these results disagree with [44], who suggest that lidocaine may have an inhibitory effect on bone regeneration in vitro study.…”

Section: First Weekcontrasting

confidence: 74%

Evaluation bone healing agents: radiological presentative on lidocaine and diclofenac in rabbits

Jadoaa,

Omar

2023

JKAS

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This study aimed to assess the impact of intraosseous injections of 2% lidocaine hydrochloride and 3.75% Diclofenac on bone regeneration. Forty-five adult male rabbits of a local breed were used to create a 3.5mm hole in the proximal third of the medial aspect of the tibia using an electric drill, with continuous isotonic regular saline irrigation to prevent thermal necrosis. The rabbits were randomly divided into three groups of fifteen each (n=15): a control group without any treatment, Group 1 (Lidocaine HCl), which received a daily dose of 2% lidocaine HCl (2 mg/kg body weight) for five days post-operation (P.O.), and Group 2 (Diclofenac), which received 3.75% Diclofenac (20 mg/kg body weight). Radiographic evaluations were conducted at the end of the 7th, 14th, and 21st days P.O. The findings demonstrated accelerated bone regeneration and development in Group 1 compared to Group 2 and the control group. In conclusion, intraosseous injection of 2% Lidocaine HCl (2mg/kg B.W.) showed a stimulatory effect on bone healing, with osteogenic tissue and trabecular bone formation being visible in radiographic images at the end of the first week, indicating a more effective outcome compared to the Diclofenac and control groups.

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Section: First Weekcontrasting

confidence: 74%

Evaluation bone healing agents: radiological presentative on lidocaine and diclofenac in rabbits

Jadoaa,

Omar

2023

JKAS

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“…Clinically, the traumatic dental injuries and caries management might expose the pulp and cause aseptic inflammation [ 5 ]. There is evidence that lower levels of pro-inflammatory mediators may promote tissue repair [ 6 ], while intense inflammatory could inhibite the differentiative ability of hDPSCs [ 7 , 8 ]. In addition, the pathological process of pulpitis reflects the characteristics of oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Injectable CNPs/DMP1-loaded self-assembly hydrogel regulating inflammation of dental pulp stem cells for dentin regeneration

Zhao,

Song,

et al. 2024

Materials Today Bio

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Vapor Sublimation and Deposition Polymerization to Fabricate a Directional Scaffold for Guiding Tubular Dentin Regeneration

Christy,

Chuang,

et al. 2024

Adv Funct Materials

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Dental caries, or tooth decay, is a widespread problem and is generally considered irreversible, yet a regeneration solution exists to cure them. In this study, a multifunctional and biocompatible dental scaffold is fabricated by a unique vapor sublimation and deposition polymerization process with the well‐accepted material Parylene, resulting in the construction of a 3D and porous polymer scaffold that accommodates living cells and a combination of growth factor molecules in a single fabrication process, which differentiates the coating formation from a conventional vapor process. Physically, a directional interior structure is constructed to guide dental pulp stem cells (DPSCs) attachment and alignment. Biochemically, necessary growth factors, including Wnt‐3a and FGF‐2, are incorporated within the scaffold during fabrication to guide the cell differentiation of odontogenesis. The synergistic effects of the attachment and alignment of DPSCs, as well as the biocompatibility and odontogenic activities of the components accommodated in the scaffold, result in the upregulation of the cell differentiation into odontoblasts, as shown by the morphology of odontoblasts and the expressions of odontogenesis markers. Thus, the reported fabrication technique and its products represent an alternative approach for dentin regeneration in dental caries and tooth decay.

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Lidocaine intensifies the anti-osteogenic effect on inflammation-induced human dental pulp stem cells via mitogen-activated protein kinase inhibition

Cited by 3 publications

References 43 publications

Evaluation bone healing agents: radiological presentative on lidocaine and diclofenac in rabbits

Evaluation bone healing agents: radiological presentative on lidocaine and diclofenac in rabbits

Injectable CNPs/DMP1-loaded self-assembly hydrogel regulating inflammation of dental pulp stem cells for dentin regeneration

Vapor Sublimation and Deposition Polymerization to Fabricate a Directional Scaffold for Guiding Tubular Dentin Regeneration

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