“…Nevertheless, this study did not compare the efficacy of hydrogel with MTA, which is the most commonly used repair material in clinical practice, and lacked studies investigating the relevant mechanisms. 51 Figure 4 WB and IF reveal odontogenic effects of the L-(CaP-ZnP)/SA nanocomposite hydrogel. ( A and B ) Western blot and semiquantitative assessment displaying the expression of the odontogenic-related protein (Runx2) on day 7.…”
“…Nevertheless, this study did not compare the efficacy of hydrogel with MTA, which is the most commonly used repair material in clinical practice, and lacked studies investigating the relevant mechanisms. 51 Figure 4 WB and IF reveal odontogenic effects of the L-(CaP-ZnP)/SA nanocomposite hydrogel. ( A and B ) Western blot and semiquantitative assessment displaying the expression of the odontogenic-related protein (Runx2) on day 7.…”
“…First, the hydrogel can be used as a drug delivery system to deliver drugs precisely to the repair site in a sustained, metered manner [ [25] , [26] , [27] ]. Second, it can support and promote cell proliferation, differentiation, and tissue regeneration, providing favorable conditions for successful tissue engineering [ 22 , 28 , 29 ]. However, despite the potential applications of self-assembled polypeptide hydrogels for tissue engineering and wound repair, the current therapeutic results are not ideal, especially for tendon repair.…”
Engineered biomaterials are materials specifically designed to interact with biological systems for biomedical applications. This paper offers the comprehensive analysis of global clinical trial trends involving such materials. We surveyed 834 studies in the
ClinicalTrials.gov
database and explored biomaterial types, their initiation points, and durations in clinical trials. Predominantly, synthetic and natural polymers, particularly silicone and collagen, are used. Trials, focusing on ophthalmology, dentistry, and vascular medicine, are primarily conducted in the United States, Canada, and Italy. These trials encompass a broad demographic, and trials enrolled fewer than 100 participants. The study duration varied ranging from 0.5 to 4.5 years. These biomaterials are mainly bioresorbable or bioinert, with the integration of cells in biomaterials remaining an underexplored area. Our findings shed light on current practices and future potentials of engineered biomaterials in clinical research, offering insights for advancing this dynamic field globally.
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