Lidocaine Attenuates Cytokine-Induced Cell Injury in Endothelial and Vascular Smooth Muscle Cells

Abstract

This study demonstrates that lidocaine attenuates cytokine-induced injury of endothelial and vascular smooth muscle cells via mechanisms involving adenosine triphosphate-sensitive potassium channels. Protection of the vasculature from cytokine-induced inflammation may preserve important physiological endothelial and vascular smooth muscle functions.

Estimated Maximal Safe Dosages of Tumescent Lidocaine

“…There is a growing literature indicating that systemic IV lidocaine may have beneficial perioperative effects, including preemptive analgesia, reduced postoperative narcotic requirements, and reduced systemic inflammatory response to surgical trauma. 33,34,[42][43][44][45][46][47] The observation that tumescent infiltration produces a concentration-time profile similar to a constant IV infusion of lidocaine suggests a new hypothesis, to be tested in the future, that local TLA may have desirable systemic effects.…”

Do Amide Local Anesthetics Play a Therapeutic Role in the Perioperative Management of Cancer Patients?

“…46 In addition, PMN activation and priming are also attenuated by local anesthetics. [47][48][49][50] Together with other evidence of certain protective, anti-inflammatory effects on the endothelium, 51,52 these results might indicate a potential beneficial effect of the use of local anesthetics in patients undergoing cancer surgery, as the extravasation of CTCs during the perioperative period might be impeded by the preservation of endothelial barrier function and by a decrease in the adhesion of leukocytes and cancer cells to the endothelium and their subsequent transendothelial migration.…”

A Review of Intravenous Lidocaine Infusion Therapy for Paediatric Acute and Chronic Pain Management

“…Lidocaine inhibits the migration of granulocytes and release of lysosomal enzymes which leads to decreased release of pro-and anti-inflammatory cytokines [146,162,[164][165][166][167]. Animal studies demonstrate that these anti-inflammatory effects of lidocaine are mediated by inhibition of VGSC, G-proteincoupled receptors and ATP-sensitive potassium channels.…”