Lichen sclerosus of the oral cavity. Case report and review of literature.

Sherlin, Herald J; Ramalingam, Karthikeyan; Natesan, Anuja; Ramani, Pratibha; Premkumar, Priya; Thiruvenkadam, Chandrasekar

doi:10.3315/jdcr.2010.1052

Cited by 12 publications

(25 citation statements)

References 23 publications

(25 reference statements)

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“…3,4 There are also case reports of LS affecting the mucosal surface of the oral cavity. 5 Other mucosal sites are usually spared, but there are at least two case reports of the disease affecting the mucosa of vagina. 6,7 The diagnosis of LS can be made clinically, but is often confirmed by histology.…”

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confidence: 99%

Lichen sclerosus and risk of cancer

Halonen

Jakobsson

Heikinheimo

et al. 2017

Intl Journal of Cancer

106

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Malignant potential of lichen sclerosus (LS) has been suspected, but evidence is sparse. We used the population-based Finnish Cancer Registry data to further study this connection. We identified all women with the diagnosis of LS (n = 7,616) listed in the Finnish Hospital Discharge Registry from 1970 to 2012. The cohort was followed through the Finnish Cancer Registry for subsequent cancer diagnoses until 2014. Standardized incidence ratios (SIRs) were calculated for different cancers by dividing the observed numbers of cancers by expected ones. The expected numbers were based on national cancer incidence rates. During the follow-up period, we found 812 cancers among patients with LS (SIR: 1.13, 95% CI 1.05-1.21). LS was associated with an increased risk of vulvar (182 cases, SIR: 33.6, 95% CI 28.9-38.6) and vaginal cancer (4 cases, SIR: 3.69, 95% CI 1.01-9.44). The risk of cancers of the uterine cervix and lung was significantly decreased. LS is associated with an increased risk for vulvar and vaginal cancer. These data are important when designing the care of women diagnosed with LS.

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confidence: 99%

Lichen sclerosus and risk of cancer

Halonen

Jakobsson

Heikinheimo

et al. 2017

Intl Journal of Cancer

106

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“…Among the strengths of this study is the systematic search of three comprehensive databases. There have been other reviews of OLS, but these were not systematic reviews. The weakness of this review is that some relevant articles may have been excluded owing to limiting the language to English, and that there might exist articles not included in the three aforementioned databases.…”

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confidence: 99%

Oral lichen sclerosus: a systematic review of reported cases and two new cases

2018

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Lichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease with uncertain etiology. It occurs as white plaque-like lesions mostly in the anogenital skin. Oral mucosal involvement is extremely rare. This study aims to summarize the features of published oral lichen sclerosus (OLS) and two new cases. A systematic search of the English literature from 1955 to 2016 was performed in MEDLINE, Scopus, and Web of Science, and cross-references were searched manually. Search phrases included "lichen sclerosus," "mouth," "oral," "lip," "palate," "floor of mouth," "tongue," "gingiva," "buccal mucosa," and "mouth diseases." Cases with clinical and histopathological confirmation of diagnosis of OLS were included. A total of 41 (39 published and 2 new) histologically confirmed OLS cases were available. The median age of OLS patients was 31 years, and 66% of the patients were female. Most of the OLS lesions were asymptomatic. They were located in the labial mucosa (n = 20), lip (n = 15), buccal mucosa (n = 14), gingiva (n = 12), tongue (n = 12), and palate (n = 7). OLS is rare and typically presents as asymptomatic, white, plaque-like lesions. Malignant transformation of preexisting OLS has not been reported.

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“…Clinically, it presents as white, sometimes painful, pruritic papules or plaques. Despite its predilection for the anogenital regions the condition can occur throughout the body, although lesions of the oral mucosa are exceedingly rare and those involving the gingiva are even more so . In the oral mucosa LS is seen typically in middle‐aged females, the most common sites being the lower lip, buccal mucosa and upper lip .…”

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confidence: 99%

“…Despite its predilection for the anogenital regions the condition can occur throughout the body, although lesions of the oral mucosa are exceedingly rare and those involving the gingiva are even more so . In the oral mucosa LS is seen typically in middle‐aged females, the most common sites being the lower lip, buccal mucosa and upper lip . An increased risk of genital squamous cell carcinoma (SCC) has been documented in genital LS, thus resulting in an increased need for close follow‐up and management of affected patients .…”

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confidence: 99%

“…In the oral mucosa LS is seen typically in middle‐aged females, the most common sites being the lower lip, buccal mucosa and upper lip . An increased risk of genital squamous cell carcinoma (SCC) has been documented in genital LS, thus resulting in an increased need for close follow‐up and management of affected patients . Malignancy involving oral cases of LS, however, has not been reported .…”

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confidence: 99%

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