A case of oral lichen sclerosus with gingival involvement and <i><scp>B</scp>orrelia</i> identification

George, Alan A.; Hixson, Caleb; Peckham, Steven J.; Tyler, Donald E.; Zelger, Bernhard

doi:10.1111/his.12363

Cited by 9 publications

(3 citation statements)

References 9 publications

(24 reference statements)

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“…In addition to the present case, the oral mucosa, with extension to the labial mucosa, was a common oral site [20][21][22], as well as the vermilion of the lip [22,23]. Oral LS can also affect the palate [21], gingiva [8,22], and tongue [22,23,25]. It may frequently occur in the absence of skin or genital lesions [22,[25][26][27][28].…”

Section: Discussionmentioning

confidence: 69%

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Oral lichen sclerosus expressing extracellular matrix proteins and IgG4-positive plasma cells

Xavier¹,

Prates²,

Gurgel³

et al. 2014

Dermatology Online Journal

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Lichen sclerosus (LS) is a mucocutaneous disease with uncommon oral involvement. The etiology is not yet well understood, but LS has been associated with autoimmune, genetic, and immunological factors. We report a 47-year-old man with LS that exhibited an asymptomatic white plaque with red patches on the maxillary alveolar mucosa extending to the labial mucosa. He had no other skin disease. Positive immunostaining for tenascin and scarcity of fibronectin suggested extracellular matrix reorganization. Elastin immunostaining indicated a reduction of elastic fibers. Immunoexpression of collagen IV in blood vessels and its absence in the epithelial basement membrane, together with diffuse MMP-9 immunoexpression, suggested altered proteolytic activity. Mast cell staining bordering areas of sclerosis indicated a possible role in the synthesis of collagen. IgG4 positivity in plasma cells suggested a role in the fibrogenesis. This is an unusual presentation of oral LS and we discuss immunohistochemical findings regarding cellular and extracellular matrix components.

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Section: Discussionmentioning

confidence: 69%

“…Involvement of the oral mucosa in the absence of simultaneous genital or skin lesions is also uncommon [3,4]. Despite its idiopathic etiology, associations of LS with autoimmune and sex hormone disorders, genetic and immunological factors [5,6], and infection with possible role of Borrelia burgdorferi involvement have been proposed [7,8].…”

Section: Introductionmentioning

confidence: 99%

Oral lichen sclerosus expressing extracellular matrix proteins and IgG4-positive plasma cells

Xavier¹,

Prates²,

Gurgel³

et al. 2014

Dermatology Online Journal

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“…In a case reported by George et al ( 26 ), Borrelia Burgdorferi was identified by Focus-Floating microscopy. Borrelia Burgdorferi is the cause of the Lyme Borreliosis, which has the LS as the most common skin condition associated ( 27 ), deserving attention from the health care professionals.…”

Section: Discussionmentioning

confidence: 95%

Uncommon oral manifestation of lichen sclerosus: critical analysis of cases reported from 1957 to 2016

Tomo¹,

Santos²,

Queiroz³

et al. 2017

Med Oral

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BackgroundLichen sclerosus is a mucocutaneous autoimmune disease which might be initiated by infectious pathogens as Borrelia Bugrdorferi and HPV. This disease shows destructive potential and is rarely diagnosed in oral mucosa. The purpose of this paper is to evaluate the characteristics of cases described in literature from 1957 to 2016, looking to provide valuable evidence about clinicopathologic features of this disease.Material and MethodsA MedLine search was performed aiming to find oral lichen sclerosus cases in literature and discuss its demographical and pathological characteristics as well as treatment methods performed for these cases.Results34 oral lichen sclerosus cases with histological confirmation and one clinicopathologic study linked with this disease were found in literature. Oral lichen sclerosus affected most commonly female patients, were asymptomatic and not associated to skin or genital lesions. Furthermore, affected patients in a range of 7 – 70-years old (Average age = 31.81).ConclusionsOral lichen sclerosus is a rare pathologic process with slight predilection for prepubertal girls, for which topical corticosterois have demonstrated satisfactory therapeutic value. Key words:Lichen sclerosus et atrophicous, skin diseases, mouth disease, autoimmune diseases, mouth.

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Lichen Sclerosus of the Oral Mucosa

Matela

Hagström

Ruokonen

2021

Diseases of the Oral Mucosa

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A case of oral lichen sclerosus with gingival involvement and Borrelia identification

Cited by 9 publications

References 9 publications

Oral lichen sclerosus expressing extracellular matrix proteins and IgG4-positive plasma cells

Oral lichen sclerosus expressing extracellular matrix proteins and IgG4-positive plasma cells

Uncommon oral manifestation of lichen sclerosus: critical analysis of cases reported from 1957 to 2016

Lichen Sclerosus of the Oral Mucosa

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