1It is of great clinical importance to identify simple prognostic markers from preoperative 2 biopsies that could guide treatment planning. Here, we compared tumor budding (B), depth 3 of invasion (D) and the combined scores (i.e. BD histopathologic model) in preoperative 4 biopsies and the corresponding postoperative specimens of oral tongue squamous cell 5 carcinoma (OTSCC). Tumor budding and depth of invasion were evaluated in the pre-and 6 postoperative samples from 100 patients treated for OTSCC. Sensitivity and specificity 7 statistics were used. Our results showed statistically significant (P< 0.001) relationship 8 between pre-and postoperative BD scores. There was an agreement between the pre-and 9 postoperative BD model scores in 83 cases (83%) with 57.1% sensitivity (95% CI: 39.4% 10 to 73.7%) and 96.9% specificity (95% CI: 89.3% to 99.6%). Our findings suggest that the 11 BD model, analyzed from representative biopsies, could be used for the treatment planning 12 of OTSCC. 13 14 15

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This pilot RCT provides evidence for the effectiveness of TAC and TRI over PLA in the management of OLP.

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PurposeRecent reports indicate that histamine and its novel, high-affinity histamine H receptor (H R) play a role in carcinogenesis, and thus H R signalling has become a focus of increasing interest in the pathogenesis of many cancers. The roles of H R in oral epithelial dysplasia (OED), and oral tongue squamous cell carcinomas (OT SCC) are unknown. The purpose of this study was to assess H R expression in OTSCC patients and in cancer cell lines. MethodsBiopsies taken from OED, OTSCC, and healthy oral mucosa were studied by immunostaining. Primary human oral keratinocytes (HOKs) and two cancer cell lines (HSC-3 and SCC-25) were used for the in vitro studies. Quantitative

Matrix metalloproteinase-8 (MMP-8) participates in skin wound healing and inflammation. We hypothesized that MMP-8 plays a role in wound healing after tooth extraction and in periapical inflammation. Bone formation, collagen metabolism, and inflammation in tooth extraction socket and in periapical lesions were analyzed in wild-type mice and in MMP-8-deficient (MMP-8(-/-)) mice. New trabecular bone area in the extraction sockets and in periapical lesions were similar in both groups. In extraction sockets significantly more type III procollagen was synthesized, and the neutrophil and MMP-9 levels were lower in MMP-8(-/-) mice. The amount of Fas ligand, identified as a substrate for MMP-8, was lower in alveolar mucosa but higher in alveolar bone of MMP-8(-/-) mice. These results indicate that MMP-8 can modulate inflammation and collagen metabolism of alveolar bone and mucosa.

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