Lichen planus and other lichenoid dermatoses: Kids are not just little people

Benign male genital dermatoses

“…Mucosal lichen planus is a chronic condition with remissions and exacerbation, whereas cutaneous lesions tends to spontaneously resolve within a few years. 34 The most commonly affected sites are the flexor surfaces of the wrists, torso, medial thighs, anterior shins, dorsum of the hands, and glans penis. The morphology of lichen planus can present in many different forms, such as "ring-shaped" or annular, linear, hyperthrophic, atrophic, bullous, ulcerative, and pigmented lesions.…”

A Case of Cycloserine-Induced Lichenoid Drug Eruption Supported by the Lymphocyte Transformation Test

“…Lichenoid drug eruption (LDE), also known as drug-induced lichen planus, is an uncommon form of delayed-type drug eruption, but well characterized both clinically and histopathologically 123. LDE has the clinical features of lichen planus, such as widely distributed symmetric skin rashes with or without Wickham striae, typical oral lesions, and similar histopathological findings (including epidermal parakeratosis and lymphocyte infiltration into deeper layers of the dermis), but only LDE shows an elevated eosinophil number 2.…”

A Case of Cycloserine-Induced Lichenoid Drug Eruption Supported by the Lymphocyte Transformation Test

“…[1][2][3] LDE has the clinical features of lichen planus, such as widely distributed symmetric skin rashes with or without Wickham striae, typical oral lesions, and similar histopathological findings (including epidermal parakeratosis and lymphocyte infiltration into deeper layers of the dermis), but only LDE shows an elevated eosinophil number. 2 The pathogenesis of LDE is type IV hypersensitivity, and CD8+ cytotoxic T cells may secrete TNF-α-triggering keratinocyte apoptosis.…”

“…Jakyoung Kim, 1 Shinyoung Park, 2 Chul Min Jung, 3 Chee Won Oh, 4 Jae-Woo Kwon 3,5 and blood hypereosinophilia (20,640/μL). There were no other abnormalities, such as atypical lymphocytes, except for eosinophilia on blood smear and serum total Immunoglobulin E (IgE) was 1.7 U/mL.…”

“…4 A diagnosis of LDE is made based on the presence of the suspected causative agent, resolution of symptoms upon discontinuing the causative agent, as well as on clinical and histopathological features. 3 LDE accounts for 1% of all cases of drug eruption and is caused by many agents, including gold, quinidine, hydrochlorothiazide, captopril, carbamazepine, and propranolol. 2,5 LDE induced by anti-tuberculosis (anti-Tb) drugs has been reported since Frentz et al 6 first reported ethambutol (EMB)-induced LDE in 1981.…”